Olema Oncology
Vice President, Commercial Strategy and Operations
Olema Oncology, San Francisco, California, United States, 94199
Vice President, Commercial Strategy and Operations Olema Oncology is seeking a dynamic and experienced commercial leader to serve as
Vice President, Commercial Strategy and Operations
as the company’s first commercial hire. You will set the foundation and ready the company for a potential commercial launch in late 2027. Reporting to the Chief Operating and Financial Officer, you will shape and execute the company’s first product launch in the United States by establishing the commercial strategy and infrastructure to enable future growth. This is a unique opportunity to guide Olema through the transition from development-stage biotech to launch-ready organization, influencing patient access, market success, and long-term growth.
Check below to see if you have what is needed for this opportunity, and if so, make an application asap. This role may be based out of either our San Francisco, CA or Cambridge, MA office. Scope of the role
Lead a Historic First Launch : Guide Olema through its pivotal first product launch, ensuring the organization is prepared to deliver innovative therapies to patients. Shape Market Success : Establish the product’s value proposition, build relationships with payers and stakeholders, and create conditions for broad patient access. Build What Doesn’t Yet Exist : Design the commercial foundation from systems to talent that will scale with the company as it transitions from pre-launch to a fully integrated biotech. Harness Analytics : Establish commercial analytics and forecasting capabilities to generate actionable insights for data-driven decision-making and launch execution. Be the Commercial Voice : Serve as a key member of Olema’s leadership team, influencing corporate strategy and representing Olema externally with credibility and vision. As Vice President, Commercial Strategy and Operations, you will be responsible for: Responsibilities
Commercial Strategy & Launch Execution
Define and lead the go-to-market strategy for the first product, including positioning, target segments, pricing, and access considerations. Drive launch readiness planning across functions, ensuring alignment of timelines, deliverables, and success metrics. Develop forecasts and prepare to assume P&L accountability post-approval, ensuring commercial plans are financially sound and scalable.
Market Development & Patient Access
Lead disease education and market development initiatives to shape the therapeutic landscape in advance of launch. Partner with Medical Affairs to build and execute KOL and advocacy engagement strategies. Define the initial product value proposition and pricing approach; collaborate with external experts to prepare payer engagement plans. Ensure eligible patients are identified and supported with access to therapy; anticipate and resolve implementation hurdles.
Cross-Functional Leadership
Serve as the commercial voice within cross-functional leadership, partnering with Clinical, Regulatory, Medical, and Manufacturing for launch-ready execution. Provide commercial input into clinical development and regulatory strategy to align with payer, provider, and patient needs. Collaborate with colleagues and external partners to ensure alignment as the company expands beyond the US. Serve as a member of the executive leadership team and represent the commercial function in senior forums.
Team & Talent Development
Recruit, lead, and mentor the initial commercial team, building a lean organization capable of scaling as the company transitions to launch. Establish a culture of continuous development, emphasizing commercial competencies and succession planning.
Infrastructure, Change Management & Project Oversight
Establish foundational commercial infrastructure (CRM systems, demand planning, distribution channels, analytics, training) in a staged, resource-appropriate manner. Identify future capabilities needed for launch (e.g., market access, HEOR, field teams) and lead phased builds. Build a commercial analytics capability to generate insights on market trends, physician adoption, and patient access for data-driven decision making. Use forecasting and analytics to track launch readiness and inform executive decisions.
External Engagement & Partnerships
Develop relationships with payers, advocacy groups, distribution partners, and other stakeholders essential for launch success. Provide commercial insights to support business development and licensing discussions. Maintain awareness of market trends, competitive dynamics, product acceptance, and new product releases.
Qualifications (selected) 15+ years of biotech or pharmaceutical experience with oncology emphasis and a preference for breast cancer experience. Bachelor’s degree in business, Life Sciences, or related field; MBA or advanced degree strongly preferred. Proven success in building and leading high-performing teams and establishing launch-ready strategy, infrastructure, and operations. Experience preparing for and executing first commercial launches in emerging biotech settings. Deep experience shaping go-to-market strategies, launch planning, and product differentiation in competitive markets. Expertise in defining product value propositions and partnering on pricing, market access, and reimbursement strategies. Experience building and leveraging commercial analytics and forecasting capabilities for launch planning and decision-making. Strong understanding of how commercial strategy integrates with clinical development, regulatory pathways, and manufacturing. Ability to build and scale commercial teams and establish foundational infrastructure (CRM, forecasting, analytics, distribution). Strong financial and analytical acumen with accountability for forecasting and P&L readiness. Established relationships with KOLs, advocacy groups, payers, and healthcare stakeholders with executive presence to represent commercial perspectives internally and externally. Entrepreneurial mindset with experience as a first or early commercial hire, transforming organizations from development-stage to launch-ready. The base pay range for this position is expected to be
$300,000 - $350,000
annually; total compensation includes equity, bonus, and benefits. Important Information We provide equal opportunity to all employees and applicants for employment and celebrate a culture of diversity. A summary of benefits is available for all applicants. Olema does not accept agency resumes and is not responsible for fees related to unsolicited resumes. Fraud Alert : We are aware of employment scams; official Olema addresses end in @olema.com and our official site is olema.com. Do not respond to communications from unofficial sources.
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Vice President, Commercial Strategy and Operations
as the company’s first commercial hire. You will set the foundation and ready the company for a potential commercial launch in late 2027. Reporting to the Chief Operating and Financial Officer, you will shape and execute the company’s first product launch in the United States by establishing the commercial strategy and infrastructure to enable future growth. This is a unique opportunity to guide Olema through the transition from development-stage biotech to launch-ready organization, influencing patient access, market success, and long-term growth.
Check below to see if you have what is needed for this opportunity, and if so, make an application asap. This role may be based out of either our San Francisco, CA or Cambridge, MA office. Scope of the role
Lead a Historic First Launch : Guide Olema through its pivotal first product launch, ensuring the organization is prepared to deliver innovative therapies to patients. Shape Market Success : Establish the product’s value proposition, build relationships with payers and stakeholders, and create conditions for broad patient access. Build What Doesn’t Yet Exist : Design the commercial foundation from systems to talent that will scale with the company as it transitions from pre-launch to a fully integrated biotech. Harness Analytics : Establish commercial analytics and forecasting capabilities to generate actionable insights for data-driven decision-making and launch execution. Be the Commercial Voice : Serve as a key member of Olema’s leadership team, influencing corporate strategy and representing Olema externally with credibility and vision. As Vice President, Commercial Strategy and Operations, you will be responsible for: Responsibilities
Commercial Strategy & Launch Execution
Define and lead the go-to-market strategy for the first product, including positioning, target segments, pricing, and access considerations. Drive launch readiness planning across functions, ensuring alignment of timelines, deliverables, and success metrics. Develop forecasts and prepare to assume P&L accountability post-approval, ensuring commercial plans are financially sound and scalable.
Market Development & Patient Access
Lead disease education and market development initiatives to shape the therapeutic landscape in advance of launch. Partner with Medical Affairs to build and execute KOL and advocacy engagement strategies. Define the initial product value proposition and pricing approach; collaborate with external experts to prepare payer engagement plans. Ensure eligible patients are identified and supported with access to therapy; anticipate and resolve implementation hurdles.
Cross-Functional Leadership
Serve as the commercial voice within cross-functional leadership, partnering with Clinical, Regulatory, Medical, and Manufacturing for launch-ready execution. Provide commercial input into clinical development and regulatory strategy to align with payer, provider, and patient needs. Collaborate with colleagues and external partners to ensure alignment as the company expands beyond the US. Serve as a member of the executive leadership team and represent the commercial function in senior forums.
Team & Talent Development
Recruit, lead, and mentor the initial commercial team, building a lean organization capable of scaling as the company transitions to launch. Establish a culture of continuous development, emphasizing commercial competencies and succession planning.
Infrastructure, Change Management & Project Oversight
Establish foundational commercial infrastructure (CRM systems, demand planning, distribution channels, analytics, training) in a staged, resource-appropriate manner. Identify future capabilities needed for launch (e.g., market access, HEOR, field teams) and lead phased builds. Build a commercial analytics capability to generate insights on market trends, physician adoption, and patient access for data-driven decision making. Use forecasting and analytics to track launch readiness and inform executive decisions.
External Engagement & Partnerships
Develop relationships with payers, advocacy groups, distribution partners, and other stakeholders essential for launch success. Provide commercial insights to support business development and licensing discussions. Maintain awareness of market trends, competitive dynamics, product acceptance, and new product releases.
Qualifications (selected) 15+ years of biotech or pharmaceutical experience with oncology emphasis and a preference for breast cancer experience. Bachelor’s degree in business, Life Sciences, or related field; MBA or advanced degree strongly preferred. Proven success in building and leading high-performing teams and establishing launch-ready strategy, infrastructure, and operations. Experience preparing for and executing first commercial launches in emerging biotech settings. Deep experience shaping go-to-market strategies, launch planning, and product differentiation in competitive markets. Expertise in defining product value propositions and partnering on pricing, market access, and reimbursement strategies. Experience building and leveraging commercial analytics and forecasting capabilities for launch planning and decision-making. Strong understanding of how commercial strategy integrates with clinical development, regulatory pathways, and manufacturing. Ability to build and scale commercial teams and establish foundational infrastructure (CRM, forecasting, analytics, distribution). Strong financial and analytical acumen with accountability for forecasting and P&L readiness. Established relationships with KOLs, advocacy groups, payers, and healthcare stakeholders with executive presence to represent commercial perspectives internally and externally. Entrepreneurial mindset with experience as a first or early commercial hire, transforming organizations from development-stage to launch-ready. The base pay range for this position is expected to be
$300,000 - $350,000
annually; total compensation includes equity, bonus, and benefits. Important Information We provide equal opportunity to all employees and applicants for employment and celebrate a culture of diversity. A summary of benefits is available for all applicants. Olema does not accept agency resumes and is not responsible for fees related to unsolicited resumes. Fraud Alert : We are aware of employment scams; official Olema addresses end in @olema.com and our official site is olema.com. Do not respond to communications from unofficial sources.
#J-18808-Ljbffr