Eli Lilly and Company
Scientific Director – Virtual Screening Applications Expert
Eli Lilly and Company, San Diego, California, United States, 92154
Overview At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We put people first and seek individuals determined to make life better for people around the world.
You could be just the right applicant for this job Read all associated information and make sure to apply. The Lilly Small Molecule Discovery group is purpose-built to create molecules that improve lives. We focus on cutting-edge science to unlock new approaches that treat diseases with limited options. We challenge ourselves to deliver molecules with breakthrough efficacy and high safety margins, and we optimize mindset, technology, and processes for faster, more nimble execution. Our culture empowers innovative problem solving through open collaboration and individual accountability. Position Summary The Lilly Small Molecule Discovery (LSMD) organization focuses on the creation and discovery of new molecules to engage disease-relevant biological systems, test clinical hypotheses, and advance innovative medicines. To accelerate delivery of unique medicines while optimizing LSMD research investment, innovative use of computational tools will play an integral role. Lilly’s Early Molecule Discovery (EMD) team is responsible for small molecule hit-to-lead prosecution through the application of best-in-class and novel approaches to pre-portfolio targets. We seek an internationally recognized Virtual Screening (VS) Applications Expert who will be accountable for small molecule VS activities. In particular, the (Senior / Executive) Director will collaborate across the computational, structural biology, and medicinal chemistry organizations throughout the EMD organization and beyond to drive the successful application of transformative VS approaches to bolster Lilly’s ability to prosecute difficult-to-drug targets. This is an on-site role. We are seeking a candidate who is willing to relocate to one of the following locations: San Diego (CA), Indianapolis (IN) or Louisville (CO). Responsibilities
Drive the VS@Lilly platform within a matrix organization, collaborating with new target and existing therapeutic project teams to ensure VS is leveraged to identify high-quality starting points for hit-ID and multi-generational drug discovery efforts Pioneer the introduction of transformative methods into the VS@Lilly platform and push the boundaries of VS to deliver an unrivaled capability in the pharma industry Collaborate with structural biologists and modelers to maximize available structural and biophysical data for VS campaigns Deliver workflows that leverage physics- and AI-based modeling to enrich VS true positive hit rates across hard-to-drug targets Champion cutting-edge methods such as ensemble or AI-based VS techniques Develop cheminformatics tools to guide hit selection and maximize hypothesis exploration Work with medicinal chemists to triage VS hits for synthesis/purchase Streamline VS workflows in collaboration with Tech@Lilly to ensure timely impact and broader adoption Qualifications
Basic Qualifications Ph.D. in Computational Chemistry, Computational Medicinal Chemistry, or a related field 5+ years’ track record applying VS technologies to drive drug discovery toward candidate identification and beyond Demonstrated ability to champion new technologies leading to successful applications Proven ability to inspire and lead scientists across teams, functions, departments, and sites to accelerate portfolio deliveries Additional Skills/Preferences Excellent interpersonal skills and demonstrated advocacy of Diversity & Inclusion principles Passionate about coaching and developing others Extensive expertise with molecular design software tools Familiarity with fundamental concepts of medicinal chemistry and ADME Authorship on peer-reviewed publications and/or inventorship on patents/patents applications Expertise in GPCR drug discovery Some domestic and international travel is anticipated Equity, Accommodation & Benefits Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities in the hiring process. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form at https://careers.lilly.com/us/en/workplace-accommodation. This is for accommodation requests related to the application process and not for other correspondence. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Learn more about all of our groups. Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $184,500 - $270,600. Full-time employees are eligible for a company bonus (based on company and individual performance). Lilly offers a comprehensive benefits program including 401(k), pension, vacation, medical/dental/vision, flexible spending accounts, life insurance, leave benefits, and well-being programs. Lilly reserves the right to amend compensation and benefit programs as needed. #WeAreLilly
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You could be just the right applicant for this job Read all associated information and make sure to apply. The Lilly Small Molecule Discovery group is purpose-built to create molecules that improve lives. We focus on cutting-edge science to unlock new approaches that treat diseases with limited options. We challenge ourselves to deliver molecules with breakthrough efficacy and high safety margins, and we optimize mindset, technology, and processes for faster, more nimble execution. Our culture empowers innovative problem solving through open collaboration and individual accountability. Position Summary The Lilly Small Molecule Discovery (LSMD) organization focuses on the creation and discovery of new molecules to engage disease-relevant biological systems, test clinical hypotheses, and advance innovative medicines. To accelerate delivery of unique medicines while optimizing LSMD research investment, innovative use of computational tools will play an integral role. Lilly’s Early Molecule Discovery (EMD) team is responsible for small molecule hit-to-lead prosecution through the application of best-in-class and novel approaches to pre-portfolio targets. We seek an internationally recognized Virtual Screening (VS) Applications Expert who will be accountable for small molecule VS activities. In particular, the (Senior / Executive) Director will collaborate across the computational, structural biology, and medicinal chemistry organizations throughout the EMD organization and beyond to drive the successful application of transformative VS approaches to bolster Lilly’s ability to prosecute difficult-to-drug targets. This is an on-site role. We are seeking a candidate who is willing to relocate to one of the following locations: San Diego (CA), Indianapolis (IN) or Louisville (CO). Responsibilities
Drive the VS@Lilly platform within a matrix organization, collaborating with new target and existing therapeutic project teams to ensure VS is leveraged to identify high-quality starting points for hit-ID and multi-generational drug discovery efforts Pioneer the introduction of transformative methods into the VS@Lilly platform and push the boundaries of VS to deliver an unrivaled capability in the pharma industry Collaborate with structural biologists and modelers to maximize available structural and biophysical data for VS campaigns Deliver workflows that leverage physics- and AI-based modeling to enrich VS true positive hit rates across hard-to-drug targets Champion cutting-edge methods such as ensemble or AI-based VS techniques Develop cheminformatics tools to guide hit selection and maximize hypothesis exploration Work with medicinal chemists to triage VS hits for synthesis/purchase Streamline VS workflows in collaboration with Tech@Lilly to ensure timely impact and broader adoption Qualifications
Basic Qualifications Ph.D. in Computational Chemistry, Computational Medicinal Chemistry, or a related field 5+ years’ track record applying VS technologies to drive drug discovery toward candidate identification and beyond Demonstrated ability to champion new technologies leading to successful applications Proven ability to inspire and lead scientists across teams, functions, departments, and sites to accelerate portfolio deliveries Additional Skills/Preferences Excellent interpersonal skills and demonstrated advocacy of Diversity & Inclusion principles Passionate about coaching and developing others Extensive expertise with molecular design software tools Familiarity with fundamental concepts of medicinal chemistry and ADME Authorship on peer-reviewed publications and/or inventorship on patents/patents applications Expertise in GPCR drug discovery Some domestic and international travel is anticipated Equity, Accommodation & Benefits Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities in the hiring process. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form at https://careers.lilly.com/us/en/workplace-accommodation. This is for accommodation requests related to the application process and not for other correspondence. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Learn more about all of our groups. Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $184,500 - $270,600. Full-time employees are eligible for a company bonus (based on company and individual performance). Lilly offers a comprehensive benefits program including 401(k), pension, vacation, medical/dental/vision, flexible spending accounts, life insurance, leave benefits, and well-being programs. Lilly reserves the right to amend compensation and benefit programs as needed. #WeAreLilly
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