Septerna, Inc.
Overview
Septerna is a biotechnology company based in South San Francisco, CA on a mission to develop life-changing medicines. The company focuses on GPCR-targeted drug discovery using the Native Complex Platform to recapitulate GPCRs with native structure, function, and dynamics outside of the cellular context. Septerna aims to advance an emerging pipeline of GPCR-targeted small molecule programs to address previously undruggable targets. We are expanding our multidisciplinary team and value diversity of thought, expertise, and background through collaboration. Join a team of scientists, drug hunters, and business professionals who pursue ground-breaking innovations and work together to achieve our mission in a fast-paced environment. You will directly help move therapies through preclinical research, positioning them for success in the clinic, and contribute your passion and expertise to a dynamic team focused on discovering disease-modifying therapeutics for patients in need. Director, Pharmacometrics
The Director, Pharmacometrics will establish and lead the pharmacometric function as part of the Drug Metabolism Pharmacokinetics and Clinical Pharmacology Department. They will provide scientific and strategic leadership to apply modeling and simulation in drug discovery and development, partnering with Research, Translational, Clinical, and Regulatory teams to develop quantitative approaches in drug development. Responsibilities
Lead the design and execution of pharmacometric strategies across all stages of development. Utilize PK/PD, PBPK, and population PK modeling approaches to support internal decision-making on drug candidates. Serve as a key subject matter expert for pharmacometric components of clinical protocols, regulatory filings (IND, CTA, briefing documents), and global health authority interactions. Manage external consultants and CROs conducting pharmacometrics work. Act as a strategic thought partner across functions to influence program-level and portfolio-level development decisions. Stay current with regulatory guidance and scientific advances in modeling and simulation. Qualifications
PhD in pharmacometrics, pharmacokinetics, clinical pharmacology, or a related field, with 10+ years of experience in the pharmaceutical or biotechnology industry. Demonstrated leadership in pharmacometric strategy and regulatory interactions (e.g., IND, EOP1/2, NDA/BLA support). Expert knowledge of population PK/PD modeling, simulation, and quantitative pharmacology principles. Proficiency with software tools such as Gastroplus, Phoenix NLME, NONMEM, or other pharmacometrics modeling platforms. Proven ability to work in cross-functional teams and influence key development and regulatory decisions. Experience in leading pharmacometric functions in a biotech or pharma setting is strongly preferred. Excellent scientific communication, leadership, and organizational skills. Ability to operate effectively in a dynamic and entrepreneurial environment. Compensation and Benefits
The anticipated salary range for candidates who will work in South San Francisco, CA is $225,000 - $245,000. Individual pay may vary based on job-related skills, experience, work location, and relevant education or training. Septerna's compensation package also includes benefits, stock options, and an annual target bonus for full-time positions. Equal Opportunity and Privacy
We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. Septerna participates in the E-Verify program. California Consumer Privacy Act Privacy Notice for Job Applicants is available; if you are a California resident, click here for the CCPA Notice. Application Process
Apply for this job. This typically includes providing your name, contact information, and resume/CV. You may be asked to provide additional information such as education and experience. Interested in building your career at Septerna? Get future opportunities sent straight to your email. #J-18808-Ljbffr
Septerna is a biotechnology company based in South San Francisco, CA on a mission to develop life-changing medicines. The company focuses on GPCR-targeted drug discovery using the Native Complex Platform to recapitulate GPCRs with native structure, function, and dynamics outside of the cellular context. Septerna aims to advance an emerging pipeline of GPCR-targeted small molecule programs to address previously undruggable targets. We are expanding our multidisciplinary team and value diversity of thought, expertise, and background through collaboration. Join a team of scientists, drug hunters, and business professionals who pursue ground-breaking innovations and work together to achieve our mission in a fast-paced environment. You will directly help move therapies through preclinical research, positioning them for success in the clinic, and contribute your passion and expertise to a dynamic team focused on discovering disease-modifying therapeutics for patients in need. Director, Pharmacometrics
The Director, Pharmacometrics will establish and lead the pharmacometric function as part of the Drug Metabolism Pharmacokinetics and Clinical Pharmacology Department. They will provide scientific and strategic leadership to apply modeling and simulation in drug discovery and development, partnering with Research, Translational, Clinical, and Regulatory teams to develop quantitative approaches in drug development. Responsibilities
Lead the design and execution of pharmacometric strategies across all stages of development. Utilize PK/PD, PBPK, and population PK modeling approaches to support internal decision-making on drug candidates. Serve as a key subject matter expert for pharmacometric components of clinical protocols, regulatory filings (IND, CTA, briefing documents), and global health authority interactions. Manage external consultants and CROs conducting pharmacometrics work. Act as a strategic thought partner across functions to influence program-level and portfolio-level development decisions. Stay current with regulatory guidance and scientific advances in modeling and simulation. Qualifications
PhD in pharmacometrics, pharmacokinetics, clinical pharmacology, or a related field, with 10+ years of experience in the pharmaceutical or biotechnology industry. Demonstrated leadership in pharmacometric strategy and regulatory interactions (e.g., IND, EOP1/2, NDA/BLA support). Expert knowledge of population PK/PD modeling, simulation, and quantitative pharmacology principles. Proficiency with software tools such as Gastroplus, Phoenix NLME, NONMEM, or other pharmacometrics modeling platforms. Proven ability to work in cross-functional teams and influence key development and regulatory decisions. Experience in leading pharmacometric functions in a biotech or pharma setting is strongly preferred. Excellent scientific communication, leadership, and organizational skills. Ability to operate effectively in a dynamic and entrepreneurial environment. Compensation and Benefits
The anticipated salary range for candidates who will work in South San Francisco, CA is $225,000 - $245,000. Individual pay may vary based on job-related skills, experience, work location, and relevant education or training. Septerna's compensation package also includes benefits, stock options, and an annual target bonus for full-time positions. Equal Opportunity and Privacy
We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. Septerna participates in the E-Verify program. California Consumer Privacy Act Privacy Notice for Job Applicants is available; if you are a California resident, click here for the CCPA Notice. Application Process
Apply for this job. This typically includes providing your name, contact information, and resume/CV. You may be asked to provide additional information such as education and experience. Interested in building your career at Septerna? Get future opportunities sent straight to your email. #J-18808-Ljbffr