Gilead.com
Overview
At Gilead, were creating a healthier world for all people. For more than 35 years, weve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the worlds biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gileads team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and were looking for the next wave of passionate and ambitious people ready to make a direct impact. As a quantitiative systems pharmacologist, you will scope, develop and apply mechanistic disease progression and systems pharmacology models to inform multiple aspects of the drug development process, including optimizing drug candidates through mechanistic simulation, dose/target optimization, identifying biomarkers for clinical programs, and recommending doses, regimens and subpopulations for inclusion into clinical trial design. Further areas of focus include reverse translation of clinical findings and development of platform models to support combinations and inform portfolio development strategy. Responsibilities
Develop QSP models for one or more disease areas incorporating available in-house and published data. Regularly communicate with cross-functional teams to develop and periodically update modeling strategy to ensure timely and impactful execution of modeling goals. Present model findings to clinical teams and incorporate feedback as needed. Provide expert guidance across teams as needed. Contribute to regulatory documents using the appropriate level of documentation and reproducibility. Maintain accurate records including data, assumptions, parameter values, model changes, etc. while developing models. Proactively identify opportunities for applying or adapting QSP models to support portfolio and project needs. Develop and maintain reusable software tools as needed to support and streamline QSP efforts. Author manuscripts describing model development and findings as needed. Present modeling work externally at conferences and working groups. Mentor junior scientists on areas related to QSP, if needed. Basic Qualifications
10+ Years with BS/BA OR 8+ Years with MS/MA or MBA OR 5+ years of relevant experience and a PhD or PharmD degree. Preferred Qualifications
Proficiency in mathematical and computational skills needed for QSP modeling work, including but not limited to ordinary differential equations, linear algebra, statistics, optimization, and parameter inference. Relevant education in computational/systems biology, physics, engineering, or computer science. Proficiency in relevant software and programming languages which may include Python, R, C++, Julia, or MATLAB and MATLAB SimBiology (preferred). Basic understanding of molecular and cellular biology including concepts from immunology, oncology, virology, cellular signaling, etc. Working knowledge of concepts of drug development. Experience with QSP software and Bioinformatics tools for informing QSP models. Familiarity with other modeling techniques: ABMs, PDEs, SDEs, stochastic simulation, graph theoretical methods, information theoretical methods, Boolean networks, etc. Familiarity with methodologies for Bayesian parameter inference. People Leader Accountabilities
Create inclusion - knowing the business value of diverse teams, modeling inclusion, and embedding the value of diversity in the way they manage their teams. Develop talent - understand the skills, experience, aspirations and potential of their employees and coach them on current performance and future potential. Empower teams - connect the team to the organization by aligning goals, purpose, and organizational objectives, and holding them to account. They provide the support needed to remove barriers and connect their team to the broader ecosystem. Compensation and Benefits
The salary range for this position is: $195,670.00 - $253,220.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans. For additional benefits information, visit: https://www.gilead.com/careers/compensation-benefits-and-wellbeing. Equal Opportunity
Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. Applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance. For more information about equal employment opportunity protections, please view the Know Your Rights poster. #J-18808-Ljbffr
At Gilead, were creating a healthier world for all people. For more than 35 years, weve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the worlds biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gileads team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and were looking for the next wave of passionate and ambitious people ready to make a direct impact. As a quantitiative systems pharmacologist, you will scope, develop and apply mechanistic disease progression and systems pharmacology models to inform multiple aspects of the drug development process, including optimizing drug candidates through mechanistic simulation, dose/target optimization, identifying biomarkers for clinical programs, and recommending doses, regimens and subpopulations for inclusion into clinical trial design. Further areas of focus include reverse translation of clinical findings and development of platform models to support combinations and inform portfolio development strategy. Responsibilities
Develop QSP models for one or more disease areas incorporating available in-house and published data. Regularly communicate with cross-functional teams to develop and periodically update modeling strategy to ensure timely and impactful execution of modeling goals. Present model findings to clinical teams and incorporate feedback as needed. Provide expert guidance across teams as needed. Contribute to regulatory documents using the appropriate level of documentation and reproducibility. Maintain accurate records including data, assumptions, parameter values, model changes, etc. while developing models. Proactively identify opportunities for applying or adapting QSP models to support portfolio and project needs. Develop and maintain reusable software tools as needed to support and streamline QSP efforts. Author manuscripts describing model development and findings as needed. Present modeling work externally at conferences and working groups. Mentor junior scientists on areas related to QSP, if needed. Basic Qualifications
10+ Years with BS/BA OR 8+ Years with MS/MA or MBA OR 5+ years of relevant experience and a PhD or PharmD degree. Preferred Qualifications
Proficiency in mathematical and computational skills needed for QSP modeling work, including but not limited to ordinary differential equations, linear algebra, statistics, optimization, and parameter inference. Relevant education in computational/systems biology, physics, engineering, or computer science. Proficiency in relevant software and programming languages which may include Python, R, C++, Julia, or MATLAB and MATLAB SimBiology (preferred). Basic understanding of molecular and cellular biology including concepts from immunology, oncology, virology, cellular signaling, etc. Working knowledge of concepts of drug development. Experience with QSP software and Bioinformatics tools for informing QSP models. Familiarity with other modeling techniques: ABMs, PDEs, SDEs, stochastic simulation, graph theoretical methods, information theoretical methods, Boolean networks, etc. Familiarity with methodologies for Bayesian parameter inference. People Leader Accountabilities
Create inclusion - knowing the business value of diverse teams, modeling inclusion, and embedding the value of diversity in the way they manage their teams. Develop talent - understand the skills, experience, aspirations and potential of their employees and coach them on current performance and future potential. Empower teams - connect the team to the organization by aligning goals, purpose, and organizational objectives, and holding them to account. They provide the support needed to remove barriers and connect their team to the broader ecosystem. Compensation and Benefits
The salary range for this position is: $195,670.00 - $253,220.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans. For additional benefits information, visit: https://www.gilead.com/careers/compensation-benefits-and-wellbeing. Equal Opportunity
Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. Applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance. For more information about equal employment opportunity protections, please view the Know Your Rights poster. #J-18808-Ljbffr