AstraZeneca
Associate Director, Translational Medicine Lead, Haematology R&D
AstraZeneca, Gaithersburg, Maryland, us, 20883
Overview
Associate Director, Translational Medicine Lead, Haematology R&D Location: Gaithersburg, MD USA AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that emphasizes discovery, development, and commercialization of prescription medicines for serious diseases. The Haematology R&D department focuses on advancing science to deliver life-changing medicines, leveraging immuno-oncology, DNA damage response, antibody-drug conjugates, cell therapy, and epigenetics to address hematological cancers. Translational Medicine (TM) transforms haematological cancer biology into actionable insights to support therapeutic development and clinical decision-making within Oncology. TM develops translational biomarker studies, assays, validation, and analyses for leukemia, lymphoma, and myeloma across early to late-phase clinical engagements.
Key Responsibilities and Accountabilities
Develop and implement comprehensive translational science strategies encompassing patient selection, pharmacodynamics, mechanism of action, and mechanism of resistance for preclinical therapies through Phase 3 clinical studies. Deliver robust biomarker strategies and data for clinical studies based on best available science and technologies. Be accountable for development and deployment of fit-for-purpose translational assays internally and externally. Measure target engagement, pharmacodynamic biomarkers, and mechanism of action reliably and quantifiably to inform clinical decisions. Explore mechanisms of resistance and deliver data to guide decision making. Implement translational strategies into clinical studies, including sample collection protocols, laboratory manuals, clinical study protocols, and biomarker analyses in oncology and haematology studies. Analyze target expression, cancer pathway interactions, feedback mechanisms, and tumor microenvironment features in clinical samples to guide rational drug combination strategies across oncology and haematology programs. Contribute to and ensure quality of Translational Medicine clinical study reports, data reviews and interpretations, presentations, scientific publications, and recommendations to development teams and management for strategic decision-making. Collaborate with cross-functional teams including Oncology Research, Translational Medicine, clinical development, clinical operations, and product development to incorporate translational medicine strategies for molecules in early development. Influence translational strategy across the AstraZeneca portfolio to maximize scientific impact and therapeutic outcomes. Lead and manage internal and external research collaborations in clinical technologies and oncology translational research to advance portfolio objectives. Experience Required / Qualifications
PhD with experience in oncology drug development required. 2 years of experience in drug development in pharmaceutical or biotech industries. In-depth knowledge of Immunology, Haematology-Oncology biology and translational science. Prefer expertise in myeloma, leukemia and lymphoma. Highly desired experience with cell therapy, T cell engagers, and antibody-drug conjugates modalities. Proven communication, presentation and influencing skills. Strong problem solving and risk management abilities. Ability to drive, manage, execute and deliver results for complex multi-functional projects. Highly developed collaborative working skills. Ability to act as an external ambassador and to influence external organizations to enhance the image and reputation of AstraZeneca. Proven ability to motivate and develop others. Compensation and Benefits
The annual base pay for this position ranges from $134,578.00 to $201,868.00. Base pay offered may vary depending on factors including location, knowledge, skills, and experience. Our positions offer a short-term incentive bonus opportunity; eligibility to participate in equity-based long-term incentive programs (salaried roles), retirement contributions (hourly roles), and commission eligibility (sales roles). Benefits include 401(k), paid vacation and holidays, paid leaves, and health benefits (medical, prescription drug, dental, vision). Details will be provided in an offer of employment. Work Environment and Company Commitment
In-person work requires a minimum of three days per week in the office, with flexibility for individual circumstances. AstraZeneca is committed to integrity, inclusiveness, and supporting communities worldwide. AstraZeneca
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Associate Director, Translational Medicine Lead, Haematology R&D Location: Gaithersburg, MD USA AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that emphasizes discovery, development, and commercialization of prescription medicines for serious diseases. The Haematology R&D department focuses on advancing science to deliver life-changing medicines, leveraging immuno-oncology, DNA damage response, antibody-drug conjugates, cell therapy, and epigenetics to address hematological cancers. Translational Medicine (TM) transforms haematological cancer biology into actionable insights to support therapeutic development and clinical decision-making within Oncology. TM develops translational biomarker studies, assays, validation, and analyses for leukemia, lymphoma, and myeloma across early to late-phase clinical engagements.
Key Responsibilities and Accountabilities
Develop and implement comprehensive translational science strategies encompassing patient selection, pharmacodynamics, mechanism of action, and mechanism of resistance for preclinical therapies through Phase 3 clinical studies. Deliver robust biomarker strategies and data for clinical studies based on best available science and technologies. Be accountable for development and deployment of fit-for-purpose translational assays internally and externally. Measure target engagement, pharmacodynamic biomarkers, and mechanism of action reliably and quantifiably to inform clinical decisions. Explore mechanisms of resistance and deliver data to guide decision making. Implement translational strategies into clinical studies, including sample collection protocols, laboratory manuals, clinical study protocols, and biomarker analyses in oncology and haematology studies. Analyze target expression, cancer pathway interactions, feedback mechanisms, and tumor microenvironment features in clinical samples to guide rational drug combination strategies across oncology and haematology programs. Contribute to and ensure quality of Translational Medicine clinical study reports, data reviews and interpretations, presentations, scientific publications, and recommendations to development teams and management for strategic decision-making. Collaborate with cross-functional teams including Oncology Research, Translational Medicine, clinical development, clinical operations, and product development to incorporate translational medicine strategies for molecules in early development. Influence translational strategy across the AstraZeneca portfolio to maximize scientific impact and therapeutic outcomes. Lead and manage internal and external research collaborations in clinical technologies and oncology translational research to advance portfolio objectives. Experience Required / Qualifications
PhD with experience in oncology drug development required. 2 years of experience in drug development in pharmaceutical or biotech industries. In-depth knowledge of Immunology, Haematology-Oncology biology and translational science. Prefer expertise in myeloma, leukemia and lymphoma. Highly desired experience with cell therapy, T cell engagers, and antibody-drug conjugates modalities. Proven communication, presentation and influencing skills. Strong problem solving and risk management abilities. Ability to drive, manage, execute and deliver results for complex multi-functional projects. Highly developed collaborative working skills. Ability to act as an external ambassador and to influence external organizations to enhance the image and reputation of AstraZeneca. Proven ability to motivate and develop others. Compensation and Benefits
The annual base pay for this position ranges from $134,578.00 to $201,868.00. Base pay offered may vary depending on factors including location, knowledge, skills, and experience. Our positions offer a short-term incentive bonus opportunity; eligibility to participate in equity-based long-term incentive programs (salaried roles), retirement contributions (hourly roles), and commission eligibility (sales roles). Benefits include 401(k), paid vacation and holidays, paid leaves, and health benefits (medical, prescription drug, dental, vision). Details will be provided in an offer of employment. Work Environment and Company Commitment
In-person work requires a minimum of three days per week in the office, with flexibility for individual circumstances. AstraZeneca is committed to integrity, inclusiveness, and supporting communities worldwide. AstraZeneca
#J-18808-Ljbffr