BioSpace
Principal Scientist - Precision Medicine Translational Target Discovery
BioSpace, Cambridge, Massachusetts, us, 02140
Overview
Principal Scientist - Precision Medicine Translational Target Discovery What you will do Let’s do this. Let’s change the world. Precision Medicine is seeking a computational biologist to develop and substantiate therapeutic hypotheses through the integrative analysis of real-world, molecular and clinical data. In this vital role you will work in a highly collaborative and matrixed environment with multiple stakeholders spanning different therapeutic areas and modalities, computational biology, precision medicine and the human genetics team at deCODE genetics. Success in these efforts will impact our existing drugs, those in development, and drive the discovery of novel targets entering the pipeline. Example Focus Areas Include Spatial imaging and transcriptomics Multi-omics (scRNA-seq, ATAC-seq, ChIP-seq, Proteomics etc) Longitudinal clinical data such as plasma proteomics Human population genetics Develop and apply
statistical and machine learning approaches to understand features associated with clinical outcomes such as response to therapy. Build
gene regulatory networks to understand and model the impact of disease associated genetic variation or therapeutic perturbation. Translate
computational insights into decision making and communicate with diverse stakeholders. What We Expect Of You
We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a go-getter with these qualifications. Basic Qualifications
Doctorate degree (PhD OR PharmD OR MD) and 2 years of directly related experience Or Masters degree and 5 years of directly related experience Or Bachelors degree and 7 years of directly related experience Preferred Qualifications
MS or PhD and 4 years industry or academic experience Strong background in object-oriented programming and analysis of large datasets Track record of leading successful computational biology projects in clinical, translational or therapeutic science Ability to analyze complex data and distill findings into actionable insights with rigorous analysis plans and statistical/quantitative interpretation Proven ability in written, visual and oral scientific communication with a strong record of scientific publication or presentation Fundamental understanding of computational biology methods; define, build and execute the simplest necessary computational approach to solve a problem Translate biological and therapeutic concepts into computational hypotheses, perform the work, and clearly communicate analytical results visually, orally and in writing What you can expect from us
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In Addition To The Base Salary , Amgen Offers a Total Rewards Plan, Based On Eligibility, Comprising Of Health And Welfare Plans For Staff And Eligible Dependents, Financial Plans With Opportunities To Save Towards Retirement Or Other Goals, Work/life Balance, And Career Development Opportunities A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan Stock-based long-term incentives Award-winning time-off plans Flexible work models, including remote and hybrid work arrangements, where possible Apply now and make a lasting impact with the Amgen team. We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will provide reasonable accommodation to participate in the job application or interview process if needed. Seniority level
Mid-Senior level Employment type
Full-time Job function
Research, Analyst, and Information Technology Selected items and career listings are provided for reference purposes only.
#J-18808-Ljbffr
Principal Scientist - Precision Medicine Translational Target Discovery What you will do Let’s do this. Let’s change the world. Precision Medicine is seeking a computational biologist to develop and substantiate therapeutic hypotheses through the integrative analysis of real-world, molecular and clinical data. In this vital role you will work in a highly collaborative and matrixed environment with multiple stakeholders spanning different therapeutic areas and modalities, computational biology, precision medicine and the human genetics team at deCODE genetics. Success in these efforts will impact our existing drugs, those in development, and drive the discovery of novel targets entering the pipeline. Example Focus Areas Include Spatial imaging and transcriptomics Multi-omics (scRNA-seq, ATAC-seq, ChIP-seq, Proteomics etc) Longitudinal clinical data such as plasma proteomics Human population genetics Develop and apply
statistical and machine learning approaches to understand features associated with clinical outcomes such as response to therapy. Build
gene regulatory networks to understand and model the impact of disease associated genetic variation or therapeutic perturbation. Translate
computational insights into decision making and communicate with diverse stakeholders. What We Expect Of You
We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a go-getter with these qualifications. Basic Qualifications
Doctorate degree (PhD OR PharmD OR MD) and 2 years of directly related experience Or Masters degree and 5 years of directly related experience Or Bachelors degree and 7 years of directly related experience Preferred Qualifications
MS or PhD and 4 years industry or academic experience Strong background in object-oriented programming and analysis of large datasets Track record of leading successful computational biology projects in clinical, translational or therapeutic science Ability to analyze complex data and distill findings into actionable insights with rigorous analysis plans and statistical/quantitative interpretation Proven ability in written, visual and oral scientific communication with a strong record of scientific publication or presentation Fundamental understanding of computational biology methods; define, build and execute the simplest necessary computational approach to solve a problem Translate biological and therapeutic concepts into computational hypotheses, perform the work, and clearly communicate analytical results visually, orally and in writing What you can expect from us
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In Addition To The Base Salary , Amgen Offers a Total Rewards Plan, Based On Eligibility, Comprising Of Health And Welfare Plans For Staff And Eligible Dependents, Financial Plans With Opportunities To Save Towards Retirement Or Other Goals, Work/life Balance, And Career Development Opportunities A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan Stock-based long-term incentives Award-winning time-off plans Flexible work models, including remote and hybrid work arrangements, where possible Apply now and make a lasting impact with the Amgen team. We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will provide reasonable accommodation to participate in the job application or interview process if needed. Seniority level
Mid-Senior level Employment type
Full-time Job function
Research, Analyst, and Information Technology Selected items and career listings are provided for reference purposes only.
#J-18808-Ljbffr