Orukatx
Overview
Senior Medical Director, Clinical Development
– Remote or Hybrid option. In-office in Waltham, MA is required 3 days per week; Remote considered. About Us: Oruka Therapeutics (Nasdaq: ORKA) is developing novel biologics designed to set a new standard for the treatment of chronic skin diseases with the goal of achieving high rates of disease clearance. For more information, visit www.orukatx.com We are building a core team and seek top talent who want to contribute to an engaging, inclusive, and positive culture. Role Overview
The Senior Medical Director of Clinical Development plays a key role in the execution and operational oversight of clinical trials, ensuring high-quality data generation to support the safety and efficacy of our pipeline products. This role supports clinical study design, implementation, and data interpretation while working cross-functionally to align clinical activities with development plans. The Medical Director collaborates with internal and external stakeholders to ensure trial execution meets regulatory, scientific, and business objectives. Key Responsibilities
Clinical Trial Design and Oversight: supports development of clinical trial protocols, including patient selection criteria, study endpoints, and data collection methods; oversees conduct of trials at study sites to ensure adherence to protocols and GCP guidelines; reviews and interprets clinical data to assess safety and efficacy; authors and contributes to clinical and non-clinical documents (e.g., Clinical Study Protocols, Investigator Brochures, Clinical Study Reports). Medical Expertise: provides medical expertise in the therapeutic area and disease state; reviews clinical data to identify safety concerns and adverse events; stays current with medical literature and trial methodologies; contributes medical expertise to external interactions with collaborators. Cross-Functional Collaboration: works with clinical operations, regulatory affairs, medical affairs, biometrics, pre-clinical and project management to optimize the clinical development process; presents clinical data to internal and external stakeholders. Strategic Leadership: contributes to overall clinical development strategy; helps identify critical milestones and drive timelines; leads clinical contributions for clinical study reports, clinical documents, and regulatory submissions; may oversee Clinical Scientists working on the same or other programs. Qualifications
Medical degree (MD) with board certification in a relevant specialty Extensive experience in clinical research and development, ideally within the pharmaceutical industry Strong understanding of clinical trial design, GCP guidelines, and regulatory requirements Excellent communication, leadership, and analytical skills Compensation and Benefits
Competitive base salary and equity with a performance-related bonus opportunity. Salary range for Waltham, MA candidates: $294,000 to $330,000 (final offer dependent on experience and other factors). Multi-state employer; salary may vary for other states. Other benefits reflect a strong startup culture with opportunities for professional growth and development. We look forward to hearing how you can contribute to our team and mission at Oruka Therapeutics.
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Senior Medical Director, Clinical Development
– Remote or Hybrid option. In-office in Waltham, MA is required 3 days per week; Remote considered. About Us: Oruka Therapeutics (Nasdaq: ORKA) is developing novel biologics designed to set a new standard for the treatment of chronic skin diseases with the goal of achieving high rates of disease clearance. For more information, visit www.orukatx.com We are building a core team and seek top talent who want to contribute to an engaging, inclusive, and positive culture. Role Overview
The Senior Medical Director of Clinical Development plays a key role in the execution and operational oversight of clinical trials, ensuring high-quality data generation to support the safety and efficacy of our pipeline products. This role supports clinical study design, implementation, and data interpretation while working cross-functionally to align clinical activities with development plans. The Medical Director collaborates with internal and external stakeholders to ensure trial execution meets regulatory, scientific, and business objectives. Key Responsibilities
Clinical Trial Design and Oversight: supports development of clinical trial protocols, including patient selection criteria, study endpoints, and data collection methods; oversees conduct of trials at study sites to ensure adherence to protocols and GCP guidelines; reviews and interprets clinical data to assess safety and efficacy; authors and contributes to clinical and non-clinical documents (e.g., Clinical Study Protocols, Investigator Brochures, Clinical Study Reports). Medical Expertise: provides medical expertise in the therapeutic area and disease state; reviews clinical data to identify safety concerns and adverse events; stays current with medical literature and trial methodologies; contributes medical expertise to external interactions with collaborators. Cross-Functional Collaboration: works with clinical operations, regulatory affairs, medical affairs, biometrics, pre-clinical and project management to optimize the clinical development process; presents clinical data to internal and external stakeholders. Strategic Leadership: contributes to overall clinical development strategy; helps identify critical milestones and drive timelines; leads clinical contributions for clinical study reports, clinical documents, and regulatory submissions; may oversee Clinical Scientists working on the same or other programs. Qualifications
Medical degree (MD) with board certification in a relevant specialty Extensive experience in clinical research and development, ideally within the pharmaceutical industry Strong understanding of clinical trial design, GCP guidelines, and regulatory requirements Excellent communication, leadership, and analytical skills Compensation and Benefits
Competitive base salary and equity with a performance-related bonus opportunity. Salary range for Waltham, MA candidates: $294,000 to $330,000 (final offer dependent on experience and other factors). Multi-state employer; salary may vary for other states. Other benefits reflect a strong startup culture with opportunities for professional growth and development. We look forward to hearing how you can contribute to our team and mission at Oruka Therapeutics.
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