BioSpace
Principal Process Engineer – ECO Synthesis
BioSpace, Redwood City, California, United States, 94061
Principal Process Engineer – ECO Synthesis
Codexis, a biotechnology company based in Redwood City, CA, is hiring a Principal Process Engineer – Flow Biocatalysis for Oligonucleotide Synthesis as part of the ECO Synthesis platform. Responsibilities
Oversee process modeling, kinetic analysis, and reactor design (e.g., packed-bed, CSTRs, fluidized bed) for biocatalytic and/or oligonucleotide processes for RNA assets. Translate bench-scale and enzymatic processes into commercial-scale manufacturing workflows, ensuring regulatory compliance and cGMP readiness at scale. Conduct risk assessments and implement process control strategies using QbD (Quality by Design) principles. Drive external collaborations including CDMOs, equipment vendors, and academic institutions for innovative solutions and technology scouting. Collaborate with cross-functional teams including R&D, Analytical Development, MSAT, and Manufacturing to integrate ECO Synthesis platform into production pipelines. Author technical reports, protocols, and regulatory documents including CMC sections to support IND and NDA filings. The Essential Requirements
Ph.D. in Chemical Engineering, Biochemical Engineering, or related field with 8+ years of relevant industrial experience, or M.S. with 12+ years. Deep expertise in flow chemistry, biocatalysis, or oligonucleotide synthesis technologies (e.g., SPOS, enzymatic platforms). Proven track record of scaling up biocatalytic or nucleic acid processes from pilot to commercial scale. Proficient in process simulation software (e.g., Aspen Plus, COMSOL, DynoChem) and data analytics. Strong communication, leadership, and cross-functional collaboration skills. Preferred/Additional Experience
Knowledge of enzymatic RNA synthesis platforms and immobilized enzyme systems. Prior involvement in facility design or equipment specification for nucleic acid manufacturing. Experience with purification technologies such as standard column chromatography, continuous chromatography, simulated moving bed chromatography or membrane separations. Compensation and Benefits Salary range: $200,000.00 – $260,000.00 (Redwood City, CA). Final offer based on experience and other factors. Medical, dental and vision insurance; life, AD&D, disability insurance; 401(k) with company match; company equity. Paid time off including holidays; wellness time; ESPP; FSA; student debt program; mental health program; onsite amenities. About Codexis Codexis is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status.
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Codexis, a biotechnology company based in Redwood City, CA, is hiring a Principal Process Engineer – Flow Biocatalysis for Oligonucleotide Synthesis as part of the ECO Synthesis platform. Responsibilities
Oversee process modeling, kinetic analysis, and reactor design (e.g., packed-bed, CSTRs, fluidized bed) for biocatalytic and/or oligonucleotide processes for RNA assets. Translate bench-scale and enzymatic processes into commercial-scale manufacturing workflows, ensuring regulatory compliance and cGMP readiness at scale. Conduct risk assessments and implement process control strategies using QbD (Quality by Design) principles. Drive external collaborations including CDMOs, equipment vendors, and academic institutions for innovative solutions and technology scouting. Collaborate with cross-functional teams including R&D, Analytical Development, MSAT, and Manufacturing to integrate ECO Synthesis platform into production pipelines. Author technical reports, protocols, and regulatory documents including CMC sections to support IND and NDA filings. The Essential Requirements
Ph.D. in Chemical Engineering, Biochemical Engineering, or related field with 8+ years of relevant industrial experience, or M.S. with 12+ years. Deep expertise in flow chemistry, biocatalysis, or oligonucleotide synthesis technologies (e.g., SPOS, enzymatic platforms). Proven track record of scaling up biocatalytic or nucleic acid processes from pilot to commercial scale. Proficient in process simulation software (e.g., Aspen Plus, COMSOL, DynoChem) and data analytics. Strong communication, leadership, and cross-functional collaboration skills. Preferred/Additional Experience
Knowledge of enzymatic RNA synthesis platforms and immobilized enzyme systems. Prior involvement in facility design or equipment specification for nucleic acid manufacturing. Experience with purification technologies such as standard column chromatography, continuous chromatography, simulated moving bed chromatography or membrane separations. Compensation and Benefits Salary range: $200,000.00 – $260,000.00 (Redwood City, CA). Final offer based on experience and other factors. Medical, dental and vision insurance; life, AD&D, disability insurance; 401(k) with company match; company equity. Paid time off including holidays; wellness time; ESPP; FSA; student debt program; mental health program; onsite amenities. About Codexis Codexis is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status.
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