BioSpace
Overview
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees work to discover and bring medicines to those who need them, improve understanding and management of disease, and contribute to communities through philanthropy and volunteerism. We focus on people first and seek individuals determined to make life better for people globally. We serve an extraordinary purpose. For more than 140 years, Lilly has worked to discover medicines that improve lives. Discoveries start in Lilly Research Laboratories, where scientists create new medicines that address global health challenges. In the Lilly Innovation Center in Boston, Massachusetts, we explore next-generation therapeutics, new technologies, data analytics, and new care models to improve patient health and the healthcare system. Our Genetic Medicine team in Boston collaborates across disciplines to advance RNA therapies, within a start-up environment supported by a large company. The Center is located in Massachusetts’ science and technology cluster and near leading academic and industry innovators. The successful candidate will have a strong research track record in synthetic organic chemistry/chemical biology/biotechnology and be analytically minded, systematic, and data-driven. The scientist will collaborate with multidisciplinary teams across Lilly therapeutic areas to perform synthesis and related experiments to aid the development of RNA oligonucleotide drug candidates. Key Responsibilities
Design and execution of automated workflows for synthesizing, purifying, and analyzing ASOs, siRNAs, SSOs, and related oligonucleotides across various chemistries and scales using advanced instrumentation platforms. Perform synthesis and chromatographic purification of innovative phosphoramidite monomers, and conduct conjugation of novel ligands (small molecules and peptides) to oligonucleotides for targeted delivery. Apply analytical techniques including UV-Vis spectroscopy, NMR, HPLC, and LC-MS to evaluate crude and purified compounds. Interpret and organize analytical data and research outcomes for presentation to project teams. Support resolution of technical issues and contribute scientific and technical insights to ongoing projects. Provide strategic input into experimental planning, integrated data analysis, and effective communication of results to scientific teams and leadership. Maintain meticulous records of procedures and key steps to ensure reproducibility, including documentation in electronic lab notebooks in accordance with Lilly’s quality standards. Assist with general lab operations such as ordering supplies, preparing reagents, and maintaining equipment. Collaborate with colleagues across multiple sub-teams within the Lilly LGM group. Adhere strictly to all health and safety protocols and foster a diverse and inclusive laboratory environment. Basic Qualifications
Bachelor's or Master's Degree in chemistry, biochemistry, pharmacology, or a related scientific field 1+ years of work experience in an academic laboratory, or preferably in an industrial setting Additional Skills/Preferences
Demonstrated expertise in organic synthesis and advanced chromatographic purification techniques. Proficiency with analytical instruments such as HPLC and LC-MS, including data analysis and communication. Hands-on experience in conjugation and bioconjugation chemistry; familiarity with solid-phase synthesis methods for oligonucleotides or peptides is highly desirable. Adaptable and motivated to thrive in a dynamic, fast-paced research environment. Strong communication and collaboration skills for working across interdisciplinary teams. Excellent organizational abilities, attention to detail, critical thinking, and ability to multitask and learn new methodologies. Proficiency in processing and visualizing data from diverse sources to derive meaningful insights. Proficient with Microsoft Excel, Word, PowerPoint, and relevant analytical software. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities in the application process. If you require accommodation to submit a resume, please complete the accommodation request form at the Lilly careers site. Lilly is proud to be an EEO employer and does not discriminate on the basis of age, race, color, religion, gender identity or expression, sexual orientation, disability, or other legally protected status. We encourage participation in employee resource groups (ERGs) and provide various benefits and compensation based on education, experience, and location.
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At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees work to discover and bring medicines to those who need them, improve understanding and management of disease, and contribute to communities through philanthropy and volunteerism. We focus on people first and seek individuals determined to make life better for people globally. We serve an extraordinary purpose. For more than 140 years, Lilly has worked to discover medicines that improve lives. Discoveries start in Lilly Research Laboratories, where scientists create new medicines that address global health challenges. In the Lilly Innovation Center in Boston, Massachusetts, we explore next-generation therapeutics, new technologies, data analytics, and new care models to improve patient health and the healthcare system. Our Genetic Medicine team in Boston collaborates across disciplines to advance RNA therapies, within a start-up environment supported by a large company. The Center is located in Massachusetts’ science and technology cluster and near leading academic and industry innovators. The successful candidate will have a strong research track record in synthetic organic chemistry/chemical biology/biotechnology and be analytically minded, systematic, and data-driven. The scientist will collaborate with multidisciplinary teams across Lilly therapeutic areas to perform synthesis and related experiments to aid the development of RNA oligonucleotide drug candidates. Key Responsibilities
Design and execution of automated workflows for synthesizing, purifying, and analyzing ASOs, siRNAs, SSOs, and related oligonucleotides across various chemistries and scales using advanced instrumentation platforms. Perform synthesis and chromatographic purification of innovative phosphoramidite monomers, and conduct conjugation of novel ligands (small molecules and peptides) to oligonucleotides for targeted delivery. Apply analytical techniques including UV-Vis spectroscopy, NMR, HPLC, and LC-MS to evaluate crude and purified compounds. Interpret and organize analytical data and research outcomes for presentation to project teams. Support resolution of technical issues and contribute scientific and technical insights to ongoing projects. Provide strategic input into experimental planning, integrated data analysis, and effective communication of results to scientific teams and leadership. Maintain meticulous records of procedures and key steps to ensure reproducibility, including documentation in electronic lab notebooks in accordance with Lilly’s quality standards. Assist with general lab operations such as ordering supplies, preparing reagents, and maintaining equipment. Collaborate with colleagues across multiple sub-teams within the Lilly LGM group. Adhere strictly to all health and safety protocols and foster a diverse and inclusive laboratory environment. Basic Qualifications
Bachelor's or Master's Degree in chemistry, biochemistry, pharmacology, or a related scientific field 1+ years of work experience in an academic laboratory, or preferably in an industrial setting Additional Skills/Preferences
Demonstrated expertise in organic synthesis and advanced chromatographic purification techniques. Proficiency with analytical instruments such as HPLC and LC-MS, including data analysis and communication. Hands-on experience in conjugation and bioconjugation chemistry; familiarity with solid-phase synthesis methods for oligonucleotides or peptides is highly desirable. Adaptable and motivated to thrive in a dynamic, fast-paced research environment. Strong communication and collaboration skills for working across interdisciplinary teams. Excellent organizational abilities, attention to detail, critical thinking, and ability to multitask and learn new methodologies. Proficiency in processing and visualizing data from diverse sources to derive meaningful insights. Proficient with Microsoft Excel, Word, PowerPoint, and relevant analytical software. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities in the application process. If you require accommodation to submit a resume, please complete the accommodation request form at the Lilly careers site. Lilly is proud to be an EEO employer and does not discriminate on the basis of age, race, color, religion, gender identity or expression, sexual orientation, disability, or other legally protected status. We encourage participation in employee resource groups (ERGs) and provide various benefits and compensation based on education, experience, and location.
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