Vertex Pharmaceuticals
Manufacturing Science & Technology Principal Scientist, Material Science
Vertex Pharmaceuticals, Boston, Massachusetts, us, 02298
Overview
MSAT Principal Scientist
Materials Science, Vertex Pharmaceuticals (Boston). The Principal Scientist, Manufacturing Science and Technology (MSAT)
Materials Science will support the Biopharmaceutical Science and Manufacturing Organization (BSMO) network by applying a deep understanding of relationships between materials properties, process conditions, and final product quality. The role requires in-depth knowledge of materials science and engineering principles applied to materials and improved process understanding, with knowledge applicable to biologics and cell therapies. Key Responsibilities
Represent the MSAT function in cross-functional teams as a materials science SME for single-use systems, cell culture media, cytokines, and/or small/large molecule raw materials. Support the development of key quality attributes of critical raw materials used in Vertexs biologics and cell therapy processes. Facilitate the use of key quality attributes of critical raw materials for material control and investigations. Drive through partnerships within MSAT the use of data analytics for raw material analysis that includes but is not limited to statistical process control / control charts for CoA attributes, correlation between raw material attributes and process performance etc. Support drafting material qualification reports with cross functional teams. Support procedures and business processes to conduct raw material technical assessments, onboarding new materials and technologies, alternate material sources, as well as supplier-initiated material change notifications. Collaborate with risk management and program management functions to articulate technical risks and develop/manage mitigations. Minimal Requirements
Requires 5-7 years of relevant experience in the biopharmaceutical industry or the equivalent combination of education and experience. Advanced degree (MS/ Ph.D./ Eng Doc) in Science/Engineering is preferred. Deep knowledge of cell culture media formulations and manufacturing, single-use-systems, and small/large molecule and CGT materials. Previous experience working in a highly matrixed environment. Extensive experience with biologics and cell therapy process development, and cGMP manufacturing. Experience with cGMP regulations/guidance and regulatory agency inspections. Experience with continuous improvement, proficiency with operational excellence preferred. Experience working with external manufacturing partners (CDMOs), suppliers, and service providers. Flexibility to work on site a minimum of 3 days per week. Up to 10% travel expected. Pay Range $142,800 - $214,200 Disclosure Statement The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. Flex Designation Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status In this Hybrid-Eligible role, you can choose to be designated as:
Hybrid: work remotely up to two days per week; or select On-Site: work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertexs Policy on Flex @ Vertex Program and may be changed at any time.
Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a persons race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. If you require an accommodation in connection with the hiring process, please contact the recruiter or hiring manager, or Talent Acquisition at ApplicationAssistance@vrtx.com
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MSAT Principal Scientist
Materials Science, Vertex Pharmaceuticals (Boston). The Principal Scientist, Manufacturing Science and Technology (MSAT)
Materials Science will support the Biopharmaceutical Science and Manufacturing Organization (BSMO) network by applying a deep understanding of relationships between materials properties, process conditions, and final product quality. The role requires in-depth knowledge of materials science and engineering principles applied to materials and improved process understanding, with knowledge applicable to biologics and cell therapies. Key Responsibilities
Represent the MSAT function in cross-functional teams as a materials science SME for single-use systems, cell culture media, cytokines, and/or small/large molecule raw materials. Support the development of key quality attributes of critical raw materials used in Vertexs biologics and cell therapy processes. Facilitate the use of key quality attributes of critical raw materials for material control and investigations. Drive through partnerships within MSAT the use of data analytics for raw material analysis that includes but is not limited to statistical process control / control charts for CoA attributes, correlation between raw material attributes and process performance etc. Support drafting material qualification reports with cross functional teams. Support procedures and business processes to conduct raw material technical assessments, onboarding new materials and technologies, alternate material sources, as well as supplier-initiated material change notifications. Collaborate with risk management and program management functions to articulate technical risks and develop/manage mitigations. Minimal Requirements
Requires 5-7 years of relevant experience in the biopharmaceutical industry or the equivalent combination of education and experience. Advanced degree (MS/ Ph.D./ Eng Doc) in Science/Engineering is preferred. Deep knowledge of cell culture media formulations and manufacturing, single-use-systems, and small/large molecule and CGT materials. Previous experience working in a highly matrixed environment. Extensive experience with biologics and cell therapy process development, and cGMP manufacturing. Experience with cGMP regulations/guidance and regulatory agency inspections. Experience with continuous improvement, proficiency with operational excellence preferred. Experience working with external manufacturing partners (CDMOs), suppliers, and service providers. Flexibility to work on site a minimum of 3 days per week. Up to 10% travel expected. Pay Range $142,800 - $214,200 Disclosure Statement The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. Flex Designation Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status In this Hybrid-Eligible role, you can choose to be designated as:
Hybrid: work remotely up to two days per week; or select On-Site: work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertexs Policy on Flex @ Vertex Program and may be changed at any time.
Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a persons race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. If you require an accommodation in connection with the hiring process, please contact the recruiter or hiring manager, or Talent Acquisition at ApplicationAssistance@vrtx.com
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