Neurocrine Biosciences
Principal Scientist, Chemical Development
Neurocrine Biosciences, San Diego, California, United States, 92189
About Neurocrine Biosciences
At Neurocrine Biosciences, we pride ourselves on a strong, inclusive, and positive culture based on our shared purpose and values. We are passionate about our people as we are about our purpose - to relieve suffering for people with great needs. Neurocrine Biosciences is a leading neuroscience-focused biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company’s portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington’s disease, classic congenital adrenal hyperplasia, endometriosis and uterine fibroids, as well as a robust pipeline in mid- to late-phase development. For three decades, we have applied our insight into neuroscience to treat complex conditions. For more information, visit neurocrine.com and follow the company on LinkedIn, X and Facebook. (*in collaboration with AbbVie) About the Role Note:
Responsible for research and development, tech transfer and commercialization of drug substance processes, as well as oversight of batch manufacturing and regulatory document contribution through managerial and individual input. Provides project management for CMC programs or Chemical Development projects. Manages direct reports. Your Contributions
Plans and manages projects. Represents Chemical Development on cross-functional teams. Maintains accountability for deliverables and progress on R&D and manufacturing plans for Chemical Development projects Independently designs, plans and executes activities towards the goals of one or more Chemical Development projects to support preclinical through commercial activities Supervises laboratory work and/or lab personnel and ensures safe laboratory practices Performs process R&D and optimizes synthetic routes Identifies and recommends approaches to novel ideas in Chemical Development Provides support for off-site synthesis, manufacturing activities and interaction with contractors Provides input into CMC regulatory documentation and supporting work May provide supervision of laboratory personnel and guidance for their professional development Contributes to development of policies and executes against department strategies Builds and enhances internal and external professional relationships Other duties as assigned Requirements
BS/BA in chemistry and 12+ years of experience in pharmaceutical/process development field, including API manufacturing and related lab activities; experience managing laboratory productivity is desirable MS/MA in chemistry and 10+ years of similar experience PhD in chemistry and 4+ years of similar experience; postdoc experience may be included Thorough understanding of organic chemistry and process chemistry and current literature Excellent laboratory and productivity skills API Manufacturing experience Good understanding of cGMP requirements in API Demonstration of cross-functional understanding related to drug development Assimilates data and research findings for new scientific projects Maintains broad knowledge of scientific principles and theories May develop an understanding of other areas and related dependencies Advanced knowledge of laboratory equipment/tools Ability to work as part of and lead multiple teams Exhibits leadership skill and ability to lead lower levels and/or indirect teams Excellent computer skills Excellent interpersonal, communications, problem-solving, analytical thinking skills Sees broader picture and impact on multiple programs Ability to meet multiple deadlines across various projects with accuracy and efficiency Excellent project management skills #LI-OB1 Neurocrine Biosciences is an EEO/Disability/Vets employer. We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are seeking the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up exactly with what is outlined. The annual base salary we reasonably expect to pay is $128,200.00-$185,900.00. Individual pay decisions depend on location, role complexity, job duties, requirements, and relevant experience and skills. The position offers an annual bonus with a target of 30% of base salary and eligibility for equity-based long-term incentives. Benefits include retirement savings with company match, paid vacation, holidays, personal days, caregiver/parental and medical leave, and health benefits (medical, prescription drug, dental, and vision) per plan terms.
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At Neurocrine Biosciences, we pride ourselves on a strong, inclusive, and positive culture based on our shared purpose and values. We are passionate about our people as we are about our purpose - to relieve suffering for people with great needs. Neurocrine Biosciences is a leading neuroscience-focused biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company’s portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington’s disease, classic congenital adrenal hyperplasia, endometriosis and uterine fibroids, as well as a robust pipeline in mid- to late-phase development. For three decades, we have applied our insight into neuroscience to treat complex conditions. For more information, visit neurocrine.com and follow the company on LinkedIn, X and Facebook. (*in collaboration with AbbVie) About the Role Note:
Responsible for research and development, tech transfer and commercialization of drug substance processes, as well as oversight of batch manufacturing and regulatory document contribution through managerial and individual input. Provides project management for CMC programs or Chemical Development projects. Manages direct reports. Your Contributions
Plans and manages projects. Represents Chemical Development on cross-functional teams. Maintains accountability for deliverables and progress on R&D and manufacturing plans for Chemical Development projects Independently designs, plans and executes activities towards the goals of one or more Chemical Development projects to support preclinical through commercial activities Supervises laboratory work and/or lab personnel and ensures safe laboratory practices Performs process R&D and optimizes synthetic routes Identifies and recommends approaches to novel ideas in Chemical Development Provides support for off-site synthesis, manufacturing activities and interaction with contractors Provides input into CMC regulatory documentation and supporting work May provide supervision of laboratory personnel and guidance for their professional development Contributes to development of policies and executes against department strategies Builds and enhances internal and external professional relationships Other duties as assigned Requirements
BS/BA in chemistry and 12+ years of experience in pharmaceutical/process development field, including API manufacturing and related lab activities; experience managing laboratory productivity is desirable MS/MA in chemistry and 10+ years of similar experience PhD in chemistry and 4+ years of similar experience; postdoc experience may be included Thorough understanding of organic chemistry and process chemistry and current literature Excellent laboratory and productivity skills API Manufacturing experience Good understanding of cGMP requirements in API Demonstration of cross-functional understanding related to drug development Assimilates data and research findings for new scientific projects Maintains broad knowledge of scientific principles and theories May develop an understanding of other areas and related dependencies Advanced knowledge of laboratory equipment/tools Ability to work as part of and lead multiple teams Exhibits leadership skill and ability to lead lower levels and/or indirect teams Excellent computer skills Excellent interpersonal, communications, problem-solving, analytical thinking skills Sees broader picture and impact on multiple programs Ability to meet multiple deadlines across various projects with accuracy and efficiency Excellent project management skills #LI-OB1 Neurocrine Biosciences is an EEO/Disability/Vets employer. We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are seeking the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up exactly with what is outlined. The annual base salary we reasonably expect to pay is $128,200.00-$185,900.00. Individual pay decisions depend on location, role complexity, job duties, requirements, and relevant experience and skills. The position offers an annual bonus with a target of 30% of base salary and eligibility for equity-based long-term incentives. Benefits include retirement savings with company match, paid vacation, holidays, personal days, caregiver/parental and medical leave, and health benefits (medical, prescription drug, dental, and vision) per plan terms.
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