Surrozen
Overview
We are seeking a highly motivated Scientist, for a full-time position to support drug development programs in the ophthalmology space. You will be involved in establishing in vitro model systems and cell-based assays for evaluating antibody drug efficacy and mode of action. You will also be involved in designing and executing in vivo MOA studies in various animal eye disease models, leveraging state-of-the-art technologies and techniques. The successful candidate will have a PhD degree in Biochemistry/Cell and Molecular Biology/Developmental Biology/Neurobiology and, ideally, with postdoctoral training in eye biology or ophthalmology related fields. The ideal candidate should have a good track record of peer-reviewed publications, excellent scientific vision, critical thinking, technical versatility and productivity. This position offers an exciting opportunity to contribute to many of Surrozen’s preclinical and clinical programs to potentially transform the treatment options of severe eye diseases, including DME, nAMD and dAMD. Pay Range: $110,435 - $198,420 Responsibilities
Design and execute experiments: design and perform in vitro (cell-based) and sometimes in vivo (animal-based) studies to explore disease mechanisms and test new molecules. Discover and validate targets: identify potential new targets for drug intervention and validate their role in the disease process through advanced molecular and cellular biology techniques. Develop and run assays: develop and optimize high-throughput screening assays to test and rank large pools of drug candidates. Analyze and interpret data: systematically analyze complex experimental data, critically evaluate and interpret data, draw conclusions, and present findings to project teams to guide drug development decisions. Collaborate across functions: work closely with cross-functional teams, including protein biochemists, pharmacologists, and data scientists, to drive discovery programs. Manage external partnerships: engage with and oversee work conducted by contract research organizations (CROs) for specialized tasks. Engage with key opinion leaders (KOLs): develop and maintain communication with a network of scientific advisors and consultants. Contribute to scientific strategy: stay current with scientific literature and contribute to setting the strategic direction for discovery efforts in the ophthalmology therapeutics field. Presentation and publication: publish data and research discoveries as conference abstracts, patents and peer-reviewed papers as guided by Surrozen publication strategy. Qualifications
Ph.D. in Biochemistry, Cell Biology, Molecular Biology, Developmental Biology, Neurobiology or related fields Minimum 2+ year experience in eye research with track record of peer reviewed publications Demonstrated strong wet-lab molecular and cell biology techniques, e.g. molecular cloning, qPCR, siRNA, Crispr-Cas9 gene editing, IF/IHC, ISH/FISH, FACS, ELISA, Western blotting, protein IP, mammalian cell/organoid culture, reporter/enzymatic cell-based assays, animal tissue manipulation and primary cell isolation Experience with fluorescence confocal microscopy and imaging analysis is a must Familiar with in vitro, ex vivo and animal retinal disease models Experience with high-throughput sequencing, single-cell sequencing, spatial transcriptomics, proteomic workflow, R programming and data analysis is a plus Excellent organizational and communication skills Ability to work in fast paced environment and make contributions to multiple projects Experience in coaching junior scientists or students Strong interpersonal skills and a team player committed to success and getting the job done well in a highly dynamic environment Attention to detail, self-motivated Benefits
We offer a dynamic working environment and a collaborative, passionate team Excellent benefits, including competitive employer contributions Stock Options Paid vacation, sick time and holidays Shuttle service to/from Caltrain, BART and the SSF Ferry State of the art research facility complete with bowling alley and onsite gym amenities available through The Cove Job Details
Seniority level: Mid-Senior level Employment type: Full-time Job function: Research, Analyst, and Information Technology Industries: Biotechnology Research Note: Referrals and related job postings are not part of the official description. This is the published listing for the Scientist-Principal Scientist role at Surrozen.
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We are seeking a highly motivated Scientist, for a full-time position to support drug development programs in the ophthalmology space. You will be involved in establishing in vitro model systems and cell-based assays for evaluating antibody drug efficacy and mode of action. You will also be involved in designing and executing in vivo MOA studies in various animal eye disease models, leveraging state-of-the-art technologies and techniques. The successful candidate will have a PhD degree in Biochemistry/Cell and Molecular Biology/Developmental Biology/Neurobiology and, ideally, with postdoctoral training in eye biology or ophthalmology related fields. The ideal candidate should have a good track record of peer-reviewed publications, excellent scientific vision, critical thinking, technical versatility and productivity. This position offers an exciting opportunity to contribute to many of Surrozen’s preclinical and clinical programs to potentially transform the treatment options of severe eye diseases, including DME, nAMD and dAMD. Pay Range: $110,435 - $198,420 Responsibilities
Design and execute experiments: design and perform in vitro (cell-based) and sometimes in vivo (animal-based) studies to explore disease mechanisms and test new molecules. Discover and validate targets: identify potential new targets for drug intervention and validate their role in the disease process through advanced molecular and cellular biology techniques. Develop and run assays: develop and optimize high-throughput screening assays to test and rank large pools of drug candidates. Analyze and interpret data: systematically analyze complex experimental data, critically evaluate and interpret data, draw conclusions, and present findings to project teams to guide drug development decisions. Collaborate across functions: work closely with cross-functional teams, including protein biochemists, pharmacologists, and data scientists, to drive discovery programs. Manage external partnerships: engage with and oversee work conducted by contract research organizations (CROs) for specialized tasks. Engage with key opinion leaders (KOLs): develop and maintain communication with a network of scientific advisors and consultants. Contribute to scientific strategy: stay current with scientific literature and contribute to setting the strategic direction for discovery efforts in the ophthalmology therapeutics field. Presentation and publication: publish data and research discoveries as conference abstracts, patents and peer-reviewed papers as guided by Surrozen publication strategy. Qualifications
Ph.D. in Biochemistry, Cell Biology, Molecular Biology, Developmental Biology, Neurobiology or related fields Minimum 2+ year experience in eye research with track record of peer reviewed publications Demonstrated strong wet-lab molecular and cell biology techniques, e.g. molecular cloning, qPCR, siRNA, Crispr-Cas9 gene editing, IF/IHC, ISH/FISH, FACS, ELISA, Western blotting, protein IP, mammalian cell/organoid culture, reporter/enzymatic cell-based assays, animal tissue manipulation and primary cell isolation Experience with fluorescence confocal microscopy and imaging analysis is a must Familiar with in vitro, ex vivo and animal retinal disease models Experience with high-throughput sequencing, single-cell sequencing, spatial transcriptomics, proteomic workflow, R programming and data analysis is a plus Excellent organizational and communication skills Ability to work in fast paced environment and make contributions to multiple projects Experience in coaching junior scientists or students Strong interpersonal skills and a team player committed to success and getting the job done well in a highly dynamic environment Attention to detail, self-motivated Benefits
We offer a dynamic working environment and a collaborative, passionate team Excellent benefits, including competitive employer contributions Stock Options Paid vacation, sick time and holidays Shuttle service to/from Caltrain, BART and the SSF Ferry State of the art research facility complete with bowling alley and onsite gym amenities available through The Cove Job Details
Seniority level: Mid-Senior level Employment type: Full-time Job function: Research, Analyst, and Information Technology Industries: Biotechnology Research Note: Referrals and related job postings are not part of the official description. This is the published listing for the Scientist-Principal Scientist role at Surrozen.
#J-18808-Ljbffr