Senior Scientific Fellow, Process Chemistry

Job Description General Summary: Vertex is looking for a distinguished, highly motivated, enthusiastic process chemist driven by science who will have a dual role both in the laboratory and leading projects/people. As part of the laboratory role, this individual will leverage years of expertise to develop chemical processes supporting projects from GLP Tox through to commercial, mentor younger process chemists, drive scientific initiatives and lead the use of advanced laboratory and manufacturing tools and techniques. Outside of the laboratory, your role is to lead projects, teams, and initiatives to support both the department and Vertex Pharmaceuticals as a whole. The title of the role, depending on experience level is up to Sr Scientific Fellow (equivalent to Sr Director on the scientific track). The expertise of a Fellow allows for the rapid recognition of solutions to complex synthetic problems in the lab with an eye to rapidly employing these solutions in the plant. This person will have a track record for publications, presentations and patents in the area and may be well-known in the field. This individual may develop new chemistry, improve existing chemistry, and demonstrate such chemistries by delivering material meeting quality standards appropriate for the phase of development. Key Duties And Responsibilities: Leads peers, scientifically, with consistently excellent experimental design and productive innovation in the laboratory Coordinates modes of scientific inquiry that graft together the activities of scientists from diverse functional backgrounds to overcome Project obstacles and/or advance a scientific field Demonstrates advanced intellectual and/or technological leadership Directs own technical leadership and drives project teams to more meaningful and/or productive ends Develops proposals for specific new science projects and/or business initiatives Interprets internal and external business challenges and identifies new areas of opportunity May work on cross-functional teams, lead projects or lead cross-functional technical discussions Design and perform synthetic organic experiments efficiently, independently and fit-for-purpose chemistry for the stage of development (pre-clinical through P3) Perform reaction process monitoring using a variety of analytical methods and work with analysts to develop sufficient methods Possesses an emerging external reputation exemplified by high quality publications in respected journals and invitations to write field reviews or present at prestigious external symposia Drives department/group discussions and initiatives Knowledge And Skills: Broad scientific and technical leadership in contributing to multiple projects and teams in parallel Presents data clearly and persuasively to all parts of the organization, to corporate collaborators, and at external symposia and seminars Displays highly evolved writing and oral presentation skills that enable him/her to disseminate the importance of complex findings more articulately and persuasively Assesses data integrity to provide expert interpretations and recommendations to multiple Project Teams Possesses advanced knowledge of his/her own field(s) and relevant scientific disciplines Emerging authority in PC/EMS or a key scientific discipline Experience in drafting, reviewing and submitting required documentation pertaining to the development and preparation of drug substances under cGMP environment is desirable Be familiar with SOPs and GMPs and ensure compliance with all applicable regulations and SOPs Experience and ability to draft CMC sections of INDs or CTAs is a plus. Experience in writing and transferring developed technology to outside CROs and working with suppliers to solve chemical issues for compound delivery is desired Education and Experience: Master's degree and at least 15 years of experience or a PhD and at least 11 years of experience, or the equivalent combination of education and experience. Relevant process chemistry experience with lab and plant experience Pay Range: $218,400 - $327,500

Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: On-Site Designated

Flex Eligibility Status: In this

On-Site

designated role, you will

work

five days per week on-site

with ad hoc flexibility. Note:

The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at

ApplicationAssistance@vrtx.com

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