Johnson & Johnson Innovative Medicine
Senior Principal Scientist, Cellular & Molecular Toxicology/Translational Safety
Johnson & Johnson Innovative Medicine, Spring House, Pennsylvania, United States, 19477
Overview
At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are positioned to innovate across the full spectrum of healthcare solutions today to deliver breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com Job Function
Discovery & Pre-Clinical/Clinical Development Job Sub Function
Nonclinical Safety Job Category
Scientific/Technology All Job Posting Locations
San Diego, California, United States of America; Spring House, Pennsylvania, United States of America About Innovative Medicine
Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicine Position
Senior Principal Scientist, Cellular & Molecular Toxicology/Translational Safety (location: San Diego, CA or Spring House, PA) Purpose
The Senior Principal Scientist will serve as an integral member of the Cellular & Molecular Toxicology/Translational Safety team in Translational PK/PD & Investigative Toxicology (TPPIT) and Preclinical Sciences & Translational Safety (PSTS) through evaluation and application of model systems for investigations arising from target knowledge and toxicity issues during drug development. This scientist will lead predictive investigative toxicity studies through the design and supervision of scientific and technical activities. The Sr Principal Scientist will communicate plans and updates to PSTS issues teams, project teams, and global leadership in partnership with the Global Lead of Cellular & Molecular Toxicology. You Will Be Responsible For
Lead efforts to build and refine robust high-throughput in vitro organ-specific cellular screening workflows Serve as the liaison between High throughput screening, Data Sciences, In Silico Modeling and Preclinical Safety Teams Collaborate to evaluate external technologies, platforms & CROs for novel in vitro toxicology applications Oversee conversion of mechanistic cellular, molecular & biochemical toxicology assays into high throughput predictive screening assays Work with Global Translational Safety Team to establish strategic goals and objectives Communicate screening plans and updates to leadership and multidisciplinary teams Maintain toxicology expertise through collaborations and ongoing education Identify topics for internal/external publications and contribute to scientific reports Qualifications / Requirements
Education: A minimum of a Ph.D. and postdoctoral work in Toxicology, Pharmacology, Biology or related field is required. Skills/Experience
A minimum of 2-5 years postdoctoral training and 6+ years of relevant work experience Designing and conducting mechanistic in vitro studies with high-throughput cell-based models Experience with high-throughput organotypic models including immune cells Knowledge of drug discovery and modalities beyond small molecules (preferred) Advanced knowledge of cellular and molecular toxicology; project leadership experience Collaborative problem-solving skills Experience with AI/ML and in silico toxicology modeling (preferred) Experience leading matrixed, multi-disciplinary teams Board Certification in Toxicology (preferred) Strong motivation, curiosity, organization, teamwork, and communication skills The expected pay range for this position is $137,000 to $235,750. The Company offers competitive compensation and bonuses at the company's discretion. Benefits include medical, dental, vision, life, disability, and retirement plans. Time-off benefits include Vacation, Sick time, Holidays, and Work/Family Time. See https://www.careers.jnj.com/employee-benefits for details.
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At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are positioned to innovate across the full spectrum of healthcare solutions today to deliver breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com Job Function
Discovery & Pre-Clinical/Clinical Development Job Sub Function
Nonclinical Safety Job Category
Scientific/Technology All Job Posting Locations
San Diego, California, United States of America; Spring House, Pennsylvania, United States of America About Innovative Medicine
Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicine Position
Senior Principal Scientist, Cellular & Molecular Toxicology/Translational Safety (location: San Diego, CA or Spring House, PA) Purpose
The Senior Principal Scientist will serve as an integral member of the Cellular & Molecular Toxicology/Translational Safety team in Translational PK/PD & Investigative Toxicology (TPPIT) and Preclinical Sciences & Translational Safety (PSTS) through evaluation and application of model systems for investigations arising from target knowledge and toxicity issues during drug development. This scientist will lead predictive investigative toxicity studies through the design and supervision of scientific and technical activities. The Sr Principal Scientist will communicate plans and updates to PSTS issues teams, project teams, and global leadership in partnership with the Global Lead of Cellular & Molecular Toxicology. You Will Be Responsible For
Lead efforts to build and refine robust high-throughput in vitro organ-specific cellular screening workflows Serve as the liaison between High throughput screening, Data Sciences, In Silico Modeling and Preclinical Safety Teams Collaborate to evaluate external technologies, platforms & CROs for novel in vitro toxicology applications Oversee conversion of mechanistic cellular, molecular & biochemical toxicology assays into high throughput predictive screening assays Work with Global Translational Safety Team to establish strategic goals and objectives Communicate screening plans and updates to leadership and multidisciplinary teams Maintain toxicology expertise through collaborations and ongoing education Identify topics for internal/external publications and contribute to scientific reports Qualifications / Requirements
Education: A minimum of a Ph.D. and postdoctoral work in Toxicology, Pharmacology, Biology or related field is required. Skills/Experience
A minimum of 2-5 years postdoctoral training and 6+ years of relevant work experience Designing and conducting mechanistic in vitro studies with high-throughput cell-based models Experience with high-throughput organotypic models including immune cells Knowledge of drug discovery and modalities beyond small molecules (preferred) Advanced knowledge of cellular and molecular toxicology; project leadership experience Collaborative problem-solving skills Experience with AI/ML and in silico toxicology modeling (preferred) Experience leading matrixed, multi-disciplinary teams Board Certification in Toxicology (preferred) Strong motivation, curiosity, organization, teamwork, and communication skills The expected pay range for this position is $137,000 to $235,750. The Company offers competitive compensation and bonuses at the company's discretion. Benefits include medical, dental, vision, life, disability, and retirement plans. Time-off benefits include Vacation, Sick time, Holidays, and Work/Family Time. See https://www.careers.jnj.com/employee-benefits for details.
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