Roche
Principal Engineer II, Fluidic Systems Integration, Research & Early Development
Roche, Santa Clara, California, us, 95053
Principal Engineer II, Fluidic Systems Integration, Research & Early Development
Join to apply for the
Principal Engineer II, Fluidic Systems Integration, Research & Early Development
role at
Roche At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Roche. Our Systems Technology Group, a part of Roche Sequencing Solutions, is focused on creating and advancing technologies to significantly enhance DNA sequencing workflows. We are seeking a Principal System Integration Engineer II to serve as a critical bridge between fundamental scientific discovery and tangible engineering execution during the earliest stages of research and development. This is a pivotal, hands-on role for a multidisciplinary expert who is passionate about pioneering new technologies by mastering the complex intersection of chemistry, molecular biology, and biochemistry with hardware, surfaces, and materials. Role & Responsibilities: Concept & Feasibility: You will invent, prototype, and characterize novel devices, subsystems, and workflows for next-generation sequencing applications, with a primary focus on establishing fundamental feasibility and de-risking new technological approaches Workflow Translation: You will lead the effort to translate complex, multi-step biochemical and molecular biology protocols from the benchtop onto early-stage instruments, breadboards, and custom test fixtures with novel fluidic and microfluidic systems Hands-on Development & Testing: You will personally design, build, and commission custom test fixtures, breadboards, and automation scripts required for early-stage system characterization, proof-of-concept validation, and feasibility studies Hypothesis-Driven Experimentation: You will design and execute rigorous, hypothesis-driven experiments to characterize system performance, pushing the boundaries of new technologies and identifying critical failure modes at the interface of biology, chemistry, and hardware First-Principles Troubleshooting: You will lead early-stage, deep-dive troubleshooting efforts for complex performance issues on novel systems, seamlessly connecting systemic failures back to first-principles root causes—whether molecular, chemical, material, or physical Data Analysis & Communication: You will analyze complex, multi-modal data sets, author detailed technical reports and feasibility studies, generate intellectual property, and present findings to technical teams and R&D leadership to inform technology roadmap decisions Cross-Functional Collaboration: You will serve as a key technical partner to assay development scientists and hardware design engineers, providing critical, data-driven feedback to guide the co-development of reagents, consumables, and instrument hardware, ensuring that biological requirements and engineering constraints are harmonized from day one Who You Are: Education & Experience: You have a PhD in Bioengineering, Biomedical Engineering, Chemical Engineering, Biophysics, Molecular Biology, or a closely related discipline with 7+ years of relevant industry experience; OR a Master's degree in Bioengineering, Biomedical Engineering, Chemical Engineering, Biophysics, Molecular Biology or closely related discipline with 8+ years of relevant industry experience; OR a Bachelor's degree in Bioengineering, Biomedical Engineering, Chemical Engineering, Biophysics, Molecular Biology or closely related discipline with 10+ years of relevant industry experience Core Technical Expertise: You have demonstrated, hands-on success translating complex biological or chemical workflows onto prototype instruments, breadboards, or integrated microfluidic devices in a life sciences or diagnostics R&D environment Interdisciplinary Knowledge: You possess a deep, intuitive understanding of the fundamental principles of molecular biology, biochemistry, and enzymology, and a proven ability to apply this knowledge to solve complex hardware, fluidics, and materials science challenges Fluidics & Hardware Acumen: You have proficiency in designing, building, and troubleshooting complex fluidic and microfluidic systems Problem-Solving & Mindset: You have a demonstrated ability to troubleshoot from a first-principles perspective, identifying and resolving ambiguous issues that span molecular biology, chemistry, hardware, consumables, and software Communication: You have demonstrated strong interpersonal and communication skills with the ability to communicate complex technical knowledge in a clear and understandable manner to a multidisciplinary team Preferred: You have hands-on experience defining workflows and then translating them onto instrumentation by writing custom scripts via Python, MATLAB, LabView or custom fluidic simulation software You have hands-on experience with CAD for designing custom parts, fixtures, and consumables You have experience with advanced microfabrication techniques You have a strong record of innovation, demonstrated by a portfolio of patents and/or publications in relevant fields You have direct experience using Design of Experiments (DOE) and statistical analysis tools This is an on-site position based in Santa Clara, CA. Relocation benefits are not being offered for this role. The expected salary range for this position is $127,000 - $236,000. Roche is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individual's race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law.
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Join to apply for the
Principal Engineer II, Fluidic Systems Integration, Research & Early Development
role at
Roche At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Roche. Our Systems Technology Group, a part of Roche Sequencing Solutions, is focused on creating and advancing technologies to significantly enhance DNA sequencing workflows. We are seeking a Principal System Integration Engineer II to serve as a critical bridge between fundamental scientific discovery and tangible engineering execution during the earliest stages of research and development. This is a pivotal, hands-on role for a multidisciplinary expert who is passionate about pioneering new technologies by mastering the complex intersection of chemistry, molecular biology, and biochemistry with hardware, surfaces, and materials. Role & Responsibilities: Concept & Feasibility: You will invent, prototype, and characterize novel devices, subsystems, and workflows for next-generation sequencing applications, with a primary focus on establishing fundamental feasibility and de-risking new technological approaches Workflow Translation: You will lead the effort to translate complex, multi-step biochemical and molecular biology protocols from the benchtop onto early-stage instruments, breadboards, and custom test fixtures with novel fluidic and microfluidic systems Hands-on Development & Testing: You will personally design, build, and commission custom test fixtures, breadboards, and automation scripts required for early-stage system characterization, proof-of-concept validation, and feasibility studies Hypothesis-Driven Experimentation: You will design and execute rigorous, hypothesis-driven experiments to characterize system performance, pushing the boundaries of new technologies and identifying critical failure modes at the interface of biology, chemistry, and hardware First-Principles Troubleshooting: You will lead early-stage, deep-dive troubleshooting efforts for complex performance issues on novel systems, seamlessly connecting systemic failures back to first-principles root causes—whether molecular, chemical, material, or physical Data Analysis & Communication: You will analyze complex, multi-modal data sets, author detailed technical reports and feasibility studies, generate intellectual property, and present findings to technical teams and R&D leadership to inform technology roadmap decisions Cross-Functional Collaboration: You will serve as a key technical partner to assay development scientists and hardware design engineers, providing critical, data-driven feedback to guide the co-development of reagents, consumables, and instrument hardware, ensuring that biological requirements and engineering constraints are harmonized from day one Who You Are: Education & Experience: You have a PhD in Bioengineering, Biomedical Engineering, Chemical Engineering, Biophysics, Molecular Biology, or a closely related discipline with 7+ years of relevant industry experience; OR a Master's degree in Bioengineering, Biomedical Engineering, Chemical Engineering, Biophysics, Molecular Biology or closely related discipline with 8+ years of relevant industry experience; OR a Bachelor's degree in Bioengineering, Biomedical Engineering, Chemical Engineering, Biophysics, Molecular Biology or closely related discipline with 10+ years of relevant industry experience Core Technical Expertise: You have demonstrated, hands-on success translating complex biological or chemical workflows onto prototype instruments, breadboards, or integrated microfluidic devices in a life sciences or diagnostics R&D environment Interdisciplinary Knowledge: You possess a deep, intuitive understanding of the fundamental principles of molecular biology, biochemistry, and enzymology, and a proven ability to apply this knowledge to solve complex hardware, fluidics, and materials science challenges Fluidics & Hardware Acumen: You have proficiency in designing, building, and troubleshooting complex fluidic and microfluidic systems Problem-Solving & Mindset: You have a demonstrated ability to troubleshoot from a first-principles perspective, identifying and resolving ambiguous issues that span molecular biology, chemistry, hardware, consumables, and software Communication: You have demonstrated strong interpersonal and communication skills with the ability to communicate complex technical knowledge in a clear and understandable manner to a multidisciplinary team Preferred: You have hands-on experience defining workflows and then translating them onto instrumentation by writing custom scripts via Python, MATLAB, LabView or custom fluidic simulation software You have hands-on experience with CAD for designing custom parts, fixtures, and consumables You have experience with advanced microfabrication techniques You have a strong record of innovation, demonstrated by a portfolio of patents and/or publications in relevant fields You have direct experience using Design of Experiments (DOE) and statistical analysis tools This is an on-site position based in Santa Clara, CA. Relocation benefits are not being offered for this role. The expected salary range for this position is $127,000 - $236,000. Roche is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individual's race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law.
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