GlaxoSmithKline
Associate Director, Quantitative Systems Pharmacology
GlaxoSmithKline, Cambridge, Massachusetts, us, 02140
Site Name: USA - Pennsylvania - Upper Providence, Cambridge MA, UK - Hertfordshire - Stevenage, USA - North Carolina - Durham
Posted Date: Sep 11 2025
Overview
The Department of Clinical Pharmacology & Pharmacometrics, Systems and Tools at GSK is recruiting for an Associate Director level Quantitative Systems Pharmacologist, with a robust background in HIV and Vaccines. Preferred site locations include Stevenage, UK; Collegeville, PA, USA; Durham, NC, USA; Cambridge, MA, USA. This position is suitable for professionals with a PhD, MD, PharmD or equivalent doctoral background who are experienced mathematical modellers, utilizing Quantitative Systems Pharmacology, mathematical modelling, and computational skills together with Pharmacometrics to advance GSK/ViiV\'s HIV & Vaccines portfolio. Experience building and integrating mechanistic mathematical models and disease platforms with advanced analytical techniques (such as in-silico trial frameworks and scientific machine learning) to support decision-making across exploratory research, translation, clinical development, registration, and lifecycle management is highly valued. At GSK we develop therapies across modalities for a broad range of indications. Our responsibilities commence at candidate selection stage with preparations for first-in-human trials and continue through filing, registration, and market expansion. As a member of a global department with diverse expertise, you will work in a supportive environment for scientific innovation, business impact and professional growth. Our mission is to help patients feel better and live longer, by getting ahead of disease together. Key Responsibilities
Build, develop, or utilize mechanistic models of biological, physiological, and pathophysiological processes to evaluate disease pathways and progression, as well as drug candidates or treatment modalities; conduct simulations to generate virtual patients for in-silico trials to optimize clinical trial design; conduct meta-analyses to generate knowledge through data reuse.
Develop and/or apply state-of-the-art mathematical and clinical pharmacology tools to gain insight into causal relationships between components of system-level and drug-level responses (drug-target-biomarker-disease-patient interactions).
Contribute to clinical program design and dosing regimen selection, trial protocols, translational and disease-area strategies, analysis plans, study reports, regulatory submissions, and due diligence for business development as appropriate.
Collaborate closely with biologists/virologists, clinicians, clinical pharmacologists, pharmacometricians, statisticians and other partner colleagues to inform research and development programs and improve understanding of disease mechanisms.
Learn and apply emerging modelling and simulation methodologies to enhance clinical program efficiency and investment decision quality; implement best practices and lessons learned to advance R&D pipeline contributions.
Present strategy and defend outcomes of model-based approaches to internal governance boards and regulatory agencies.
Promote Model-Informed Drug Discovery and Development (MID3) through external presentations at conferences and publications in peer-reviewed journals.
Qualifications
PhD, MD, or PharmD required.
5+ years\' experience in clinical pharmacology, modelling and simulation in pharmaceutical R&D.
Experience with mechanistic mathematical modelling and simulation (QSP, PKPD) applied to drug discovery and development problems in industry and/or academia.
Experience with mechanisms, endpoints, progression, prevention, and treatments for Vaccines and Infectious Diseases (with a focus on HIV).
Experience implementing model-informed drug development approaches to improve clinical trial success and accelerate patient access to novel therapies.
Preferred Skills & Qualifications
A doctorate relevant to Quantitative Systems Pharmacology (e.g., Mathematics, Engineering, Physics, Systems Biology, Mathematical Modelling).
Proven track record of delivering milestones on time through collaboration with multidisciplinary teams and clear stakeholder communication.
Ability to make sound judgments in complex situations and adapt to changing business needs by prioritizing tasks.
Passion for Quantitative Clinical Pharmacology and a drive to innovate for better outcomes.
Prior experience in clinical QSP, popPK/PD, and virus dynamics modelling, virtual patients, and in-silico trials in infectious diseases (HIV) and Vaccines in an industry setting.
Experience with relevant modalities (small molecule antivirals, monoclonal antibodies, mRNA vaccines, adjuvanted proteins, immune-activating agents) is a plus.
Strong drive and learning agility to build knowledge on drug-disease systems, symptom progression, standard of care, and trial design.
Strong publication record in peer-reviewed journals.
Please note this job description will not be available post-closure of the advert. For more information, visit GSK Benefits Summary for US employees. Why GSK?
GSK is a global biopharma company focused on uniting science, technology and talent to get ahead of disease together. We focus on respiratory, immunology and inflammation; oncology; HIV and infectious diseases, aiming to positively impact health at scale. We strive to create an environment where our people can thrive with a culture of ambition for patients, accountability for impact and doing the right thing. If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre. GSK is an Equal Opportunity Employer. This ensures that all qualified applicants receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information, military service or any basis prohibited by law. Please note: GSK does not accept referrals from employment businesses/agencies without prior written authorization.
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The Department of Clinical Pharmacology & Pharmacometrics, Systems and Tools at GSK is recruiting for an Associate Director level Quantitative Systems Pharmacologist, with a robust background in HIV and Vaccines. Preferred site locations include Stevenage, UK; Collegeville, PA, USA; Durham, NC, USA; Cambridge, MA, USA. This position is suitable for professionals with a PhD, MD, PharmD or equivalent doctoral background who are experienced mathematical modellers, utilizing Quantitative Systems Pharmacology, mathematical modelling, and computational skills together with Pharmacometrics to advance GSK/ViiV\'s HIV & Vaccines portfolio. Experience building and integrating mechanistic mathematical models and disease platforms with advanced analytical techniques (such as in-silico trial frameworks and scientific machine learning) to support decision-making across exploratory research, translation, clinical development, registration, and lifecycle management is highly valued. At GSK we develop therapies across modalities for a broad range of indications. Our responsibilities commence at candidate selection stage with preparations for first-in-human trials and continue through filing, registration, and market expansion. As a member of a global department with diverse expertise, you will work in a supportive environment for scientific innovation, business impact and professional growth. Our mission is to help patients feel better and live longer, by getting ahead of disease together. Key Responsibilities
Build, develop, or utilize mechanistic models of biological, physiological, and pathophysiological processes to evaluate disease pathways and progression, as well as drug candidates or treatment modalities; conduct simulations to generate virtual patients for in-silico trials to optimize clinical trial design; conduct meta-analyses to generate knowledge through data reuse.
Develop and/or apply state-of-the-art mathematical and clinical pharmacology tools to gain insight into causal relationships between components of system-level and drug-level responses (drug-target-biomarker-disease-patient interactions).
Contribute to clinical program design and dosing regimen selection, trial protocols, translational and disease-area strategies, analysis plans, study reports, regulatory submissions, and due diligence for business development as appropriate.
Collaborate closely with biologists/virologists, clinicians, clinical pharmacologists, pharmacometricians, statisticians and other partner colleagues to inform research and development programs and improve understanding of disease mechanisms.
Learn and apply emerging modelling and simulation methodologies to enhance clinical program efficiency and investment decision quality; implement best practices and lessons learned to advance R&D pipeline contributions.
Present strategy and defend outcomes of model-based approaches to internal governance boards and regulatory agencies.
Promote Model-Informed Drug Discovery and Development (MID3) through external presentations at conferences and publications in peer-reviewed journals.
Qualifications
PhD, MD, or PharmD required.
5+ years\' experience in clinical pharmacology, modelling and simulation in pharmaceutical R&D.
Experience with mechanistic mathematical modelling and simulation (QSP, PKPD) applied to drug discovery and development problems in industry and/or academia.
Experience with mechanisms, endpoints, progression, prevention, and treatments for Vaccines and Infectious Diseases (with a focus on HIV).
Experience implementing model-informed drug development approaches to improve clinical trial success and accelerate patient access to novel therapies.
Preferred Skills & Qualifications
A doctorate relevant to Quantitative Systems Pharmacology (e.g., Mathematics, Engineering, Physics, Systems Biology, Mathematical Modelling).
Proven track record of delivering milestones on time through collaboration with multidisciplinary teams and clear stakeholder communication.
Ability to make sound judgments in complex situations and adapt to changing business needs by prioritizing tasks.
Passion for Quantitative Clinical Pharmacology and a drive to innovate for better outcomes.
Prior experience in clinical QSP, popPK/PD, and virus dynamics modelling, virtual patients, and in-silico trials in infectious diseases (HIV) and Vaccines in an industry setting.
Experience with relevant modalities (small molecule antivirals, monoclonal antibodies, mRNA vaccines, adjuvanted proteins, immune-activating agents) is a plus.
Strong drive and learning agility to build knowledge on drug-disease systems, symptom progression, standard of care, and trial design.
Strong publication record in peer-reviewed journals.
Please note this job description will not be available post-closure of the advert. For more information, visit GSK Benefits Summary for US employees. Why GSK?
GSK is a global biopharma company focused on uniting science, technology and talent to get ahead of disease together. We focus on respiratory, immunology and inflammation; oncology; HIV and infectious diseases, aiming to positively impact health at scale. We strive to create an environment where our people can thrive with a culture of ambition for patients, accountability for impact and doing the right thing. If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre. GSK is an Equal Opportunity Employer. This ensures that all qualified applicants receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information, military service or any basis prohibited by law. Please note: GSK does not accept referrals from employment businesses/agencies without prior written authorization.
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