BioSpace
Overview
The Frederick National Laboratory is operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.
The Cancer Genomics Research Laboratory (CGR) investigates the contribution of germline and somatic genetic variation to cancer susceptibility and outcomes in support of the NCI's Division of Cancer Epidemiology and Genetics (DCEG). CGR is located at the NCI-Shady Grove campus in Rockville, MD and operated by Leidos Biomedical Research, Inc. We care deeply about discovering the genetic and environmental determinants of cancer, and new approaches to cancer prevention, through our molecular, genetic, and epidemiologic research of 70+ principal investigators in DCEG. Working with epidemiologists, biostatisticians and basic researchers in DCEG’s intramural program, CGR conducts genome-wide discovery studies and targeted regional approaches to identify heritable determinants of various forms of cancer. Within CGR, the Molecular and Digital Pathology Laboratory (MDPL) supports genetic and epidemiologic studies for DCEG investigators through tissue profiling and image analysis. This includes high-throughput molecular epidemiologic studies using various “omics” technologies such as AI-based histomics, proteomics-based assays (immunohistochemistry, multiplex immunofluorescence), spatial transcriptomic assays and somatic genomic analyses. We are seeking a Digital Pathology Scientist to join our team and support large-scale, international epidemiological research on cancer etiology, progression, and outcomes through integrative analyses of risk factors and tissue profiling to inform prevention and clinical strategies.
Key Roles / Responsibilities
Coordinate with existing laboratory, project management and analytical staff to track study progress from conception (developing analytical plans and study protocols) through completion (preparation of summary reports for presentation and publication).
Execute statistical analysis of epidemiologic and tissue-based data derived from image analysis of whole slide and tissue microarray (TMA) images of hematoxylin and eosin (H&E), immunohistochemical (IHC), immunofluorescence (IF), and other state-of-the-art staining modalities including emerging spatial technologies.
Accurately maintain thorough documentation and version control of data management activities (data cleaning, harmonization, and statistical analysis).
Support process improvement and assay development activities in collaboration with CGR development resources and senior laboratory management staff.
Participate in the writing and review of laboratory SOPs to help ensure image quality and data is suitable for downstream analyses. Follow established protocols and assist with deviations and corrective actions.
Meet expected schedules and performance expectations in a fast-paced research environment.
Support a culture of continuous improvement and accountability; contribute to troubleshooting of issues associated with assay processing.
Support process improvement and assay development activities in collaboration with CGR development resources and senior management staff.
Basic Qualifications
Possession of a PhD degree from an accredited college or university according to the Council for Higher Education Accreditation (CHEA). Foreign degrees must be evaluated for U.S. equivalency.
A minimum of two (2) years related experience in the fields of histopathology, digital pathology and/or data science.
Strong analytical skills and experience with statistical software applications used in public health research, such as Stata and/or R, Python, C++ (please indicate relevant software applications and degree of proficiency).
Strong understanding of molecular biology.
Experience analyzing IHC/multiplex IHC, and/or ISH data.
Careful attention to detail.
Critical thinking skills and ability to identify, document and analyze important variables in an experiment.
Demonstrated ability to learn and adopt new concepts in biomarker analysis.
Collaborative, team-oriented approach to solving problems and achieving goals.
Strong organization skills, ability to multitask and manage time effectively.
Working knowledge of Windows-based computer operating systems and Microsoft Office suite.
Must be able to obtain and maintain a security clearance.
Preferred Qualifications
Advanced degree in epidemiology, molecular biology, data science, biostatistics, or a related field.
Familiarity with eLN and/or LIMS systems for sample and workflow tracking.
Knowledge of basic histological techniques including processing and embedding, microtomy/cryotomy, H&E staining, slide coverslipping and how these variables relate to image and data quality.
Experience with digital slide scanners for brightfield and fluorescent applications.
Microscopic recognition of major human tissue types.
A general understanding of database organization and structure.
Experience with image analysis software such as Halo, QuPath, Visiopharm, Definiens, etc. (please indicate relevant software applications and level of proficiency).
Experience in the application of artificial intelligence (machine learning or deep learning) to pathology image analysis.
Commitment to Non-Discrimination All qualified applicants will receive consideration for employment without regard to sex, race, ethnicity, color, age, national origin, citizenship, religion, physical or mental disability, medical condition, genetic information, pregnancy, family structure, marital status, ancestry, domestic partner status, sexual orientation, gender identity or expression, veteran or military status, or any other basis prohibited by law. Leidos will also consider for employment qualified applicants with criminal histories consistent with relevant laws.
Pay And Benefits Pay and benefits are fundamental to any career decision. That is why we craft compensation packages that reflect the importance of the work we do for our customers. Employment benefits include competitive compensation, Health and Wellness programs, Income Protection, Paid Leave and Retirement. More details are available here.
Salary range: 76,800.00 - 128,625.00 USD. The posted pay range for this job is a general guideline and not a guarantee of compensation or salary. Additional factors considered in extending an offer include responsibilities, education, experience, knowledge, skills, and abilities, as well as internal equity and market data. The salary range posted is a full-time equivalent salary and will vary depending on scheduled hours for part-time positions.
#J-18808-Ljbffr
The Cancer Genomics Research Laboratory (CGR) investigates the contribution of germline and somatic genetic variation to cancer susceptibility and outcomes in support of the NCI's Division of Cancer Epidemiology and Genetics (DCEG). CGR is located at the NCI-Shady Grove campus in Rockville, MD and operated by Leidos Biomedical Research, Inc. We care deeply about discovering the genetic and environmental determinants of cancer, and new approaches to cancer prevention, through our molecular, genetic, and epidemiologic research of 70+ principal investigators in DCEG. Working with epidemiologists, biostatisticians and basic researchers in DCEG’s intramural program, CGR conducts genome-wide discovery studies and targeted regional approaches to identify heritable determinants of various forms of cancer. Within CGR, the Molecular and Digital Pathology Laboratory (MDPL) supports genetic and epidemiologic studies for DCEG investigators through tissue profiling and image analysis. This includes high-throughput molecular epidemiologic studies using various “omics” technologies such as AI-based histomics, proteomics-based assays (immunohistochemistry, multiplex immunofluorescence), spatial transcriptomic assays and somatic genomic analyses. We are seeking a Digital Pathology Scientist to join our team and support large-scale, international epidemiological research on cancer etiology, progression, and outcomes through integrative analyses of risk factors and tissue profiling to inform prevention and clinical strategies.
Key Roles / Responsibilities
Coordinate with existing laboratory, project management and analytical staff to track study progress from conception (developing analytical plans and study protocols) through completion (preparation of summary reports for presentation and publication).
Execute statistical analysis of epidemiologic and tissue-based data derived from image analysis of whole slide and tissue microarray (TMA) images of hematoxylin and eosin (H&E), immunohistochemical (IHC), immunofluorescence (IF), and other state-of-the-art staining modalities including emerging spatial technologies.
Accurately maintain thorough documentation and version control of data management activities (data cleaning, harmonization, and statistical analysis).
Support process improvement and assay development activities in collaboration with CGR development resources and senior laboratory management staff.
Participate in the writing and review of laboratory SOPs to help ensure image quality and data is suitable for downstream analyses. Follow established protocols and assist with deviations and corrective actions.
Meet expected schedules and performance expectations in a fast-paced research environment.
Support a culture of continuous improvement and accountability; contribute to troubleshooting of issues associated with assay processing.
Support process improvement and assay development activities in collaboration with CGR development resources and senior management staff.
Basic Qualifications
Possession of a PhD degree from an accredited college or university according to the Council for Higher Education Accreditation (CHEA). Foreign degrees must be evaluated for U.S. equivalency.
A minimum of two (2) years related experience in the fields of histopathology, digital pathology and/or data science.
Strong analytical skills and experience with statistical software applications used in public health research, such as Stata and/or R, Python, C++ (please indicate relevant software applications and degree of proficiency).
Strong understanding of molecular biology.
Experience analyzing IHC/multiplex IHC, and/or ISH data.
Careful attention to detail.
Critical thinking skills and ability to identify, document and analyze important variables in an experiment.
Demonstrated ability to learn and adopt new concepts in biomarker analysis.
Collaborative, team-oriented approach to solving problems and achieving goals.
Strong organization skills, ability to multitask and manage time effectively.
Working knowledge of Windows-based computer operating systems and Microsoft Office suite.
Must be able to obtain and maintain a security clearance.
Preferred Qualifications
Advanced degree in epidemiology, molecular biology, data science, biostatistics, or a related field.
Familiarity with eLN and/or LIMS systems for sample and workflow tracking.
Knowledge of basic histological techniques including processing and embedding, microtomy/cryotomy, H&E staining, slide coverslipping and how these variables relate to image and data quality.
Experience with digital slide scanners for brightfield and fluorescent applications.
Microscopic recognition of major human tissue types.
A general understanding of database organization and structure.
Experience with image analysis software such as Halo, QuPath, Visiopharm, Definiens, etc. (please indicate relevant software applications and level of proficiency).
Experience in the application of artificial intelligence (machine learning or deep learning) to pathology image analysis.
Commitment to Non-Discrimination All qualified applicants will receive consideration for employment without regard to sex, race, ethnicity, color, age, national origin, citizenship, religion, physical or mental disability, medical condition, genetic information, pregnancy, family structure, marital status, ancestry, domestic partner status, sexual orientation, gender identity or expression, veteran or military status, or any other basis prohibited by law. Leidos will also consider for employment qualified applicants with criminal histories consistent with relevant laws.
Pay And Benefits Pay and benefits are fundamental to any career decision. That is why we craft compensation packages that reflect the importance of the work we do for our customers. Employment benefits include competitive compensation, Health and Wellness programs, Income Protection, Paid Leave and Retirement. More details are available here.
Salary range: 76,800.00 - 128,625.00 USD. The posted pay range for this job is a general guideline and not a guarantee of compensation or salary. Additional factors considered in extending an offer include responsibilities, education, experience, knowledge, skills, and abilities, as well as internal equity and market data. The salary range posted is a full-time equivalent salary and will vary depending on scheduled hours for part-time positions.
#J-18808-Ljbffr