Amgen
Scientist - Target Discovery & Validation – Induced Proximity Platform (IPP)
Amgen, Thousand Oaks, California, United States, 91362
Overview
Scientist - Target Discovery & Validation – Induced Proximity Platform (IPP) role at Amgen. This position is located in Thousand Oaks, CA and focuses on discovery biology using induced proximity technologies to uncover novel therapeutic targets across Amgen’s key therapeutic areas including Oncology, Inflammation, and Cardiometabolic diseases. Join Amgen’s mission of serving patients. Amgen’s award-winning culture is collaborative, innovative, and science-based. If you have a passion for challenges and the opportunities within them, you’ll thrive as part of the Amgen team. Responsibilities
Design, implement, and execute complex experimental workflows to profile and validate cell surface proteins. Support target functionalization toward developing multispecific antibody therapeutics, and perform efficacy, mechanism of action (MoA) and drug response studies. Lead and support cell surface-based target discovery and validation projects using in vitro models (cell lines, primary cells, tissues, etc.). Develop approaches to validate proximity at the membrane using techniques such as proximity ligation assays (PLA), Alphascreen/AlphaLISA, and co-immunoprecipitation assays. Develop high throughput copy number analysis and receptor quantification assays using flow cytometry. Apply proximity labeling, cell surface enrichment, and related proteomics efforts for target validation and nomination studies. Support target validation using tag-based approaches and cell line engineering. Use cutting-edge software tools and collaborate with bioinformatics to analyze and interpret target discovery proteomics datasets. Collaborate across multidisciplinary teams to drive integrated target discovery, validation and functionalization efforts. Present findings internally and externally through team meetings, conferences, and peer-reviewed publications; maintain detailed electronic lab notebooks and experimental records. Qualifications
Basic Qualifications: Doctorate degree or Master’s degree and 2 years of relevant scientific experience or Bachelor’s degree and 4 years of relevant scientific experience Preferred Qualifications: Expertise in proximity labeling proteomics platforms and target validation using flow cytometry, biochemical and imaging-based techniques. Expertise in cellular proximity-based assays like PLA and Alphascreen/AlphaLISA technology. Experience in cell line generation and overexpression systems (e.g., lentiviral delivery) and functional validation of targets using cell-based assays. Experience working with large molecule therapeutics or hybrid modalities such as bispecific antibodies, T-cell engagers, or antibody-drug conjugates (ADCs). Familiarity with high-throughput automation platforms (e.g., Agilent Bravo), high-content imaging platforms and analysis software. Track record of scientific innovation as demonstrated by publications, patents, and/or conference presentations. Demonstrated ability to work collaboratively in fast-paced, multidisciplinary teams. Excellent verbal, written, and organizational skills. What you can expect from us
We offer professional and personal growth and well-being support, including competitive benefits and a collaborative culture. The annual salary range is posted; actual salary varies based on skills, experience, and qualifications. Amgen provides a Total Rewards Plan including health and welfare plans, retirement savings, work/life balance, and career development opportunities, which may include: A comprehensive benefits package with retirement and savings plan contributions, medical/dental/vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or sales-based incentives for field roles Stock-based long-term incentives Award-winning time-off plans Flexible work models, including remote and hybrid options where possible Apply now and make a lasting impact with Amgen. Visit careers.amgen.com to apply. Equal Opportunity and Accommodation
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will provide reasonable accommodation to participate in the job application or interview process, perform essential job functions, and receive other benefits and privileges of employment. Please contact us to request accommodation. Application deadline: Amgen does not have a set application deadline; we continue accepting applications until a suitable candidate is selected.
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Scientist - Target Discovery & Validation – Induced Proximity Platform (IPP) role at Amgen. This position is located in Thousand Oaks, CA and focuses on discovery biology using induced proximity technologies to uncover novel therapeutic targets across Amgen’s key therapeutic areas including Oncology, Inflammation, and Cardiometabolic diseases. Join Amgen’s mission of serving patients. Amgen’s award-winning culture is collaborative, innovative, and science-based. If you have a passion for challenges and the opportunities within them, you’ll thrive as part of the Amgen team. Responsibilities
Design, implement, and execute complex experimental workflows to profile and validate cell surface proteins. Support target functionalization toward developing multispecific antibody therapeutics, and perform efficacy, mechanism of action (MoA) and drug response studies. Lead and support cell surface-based target discovery and validation projects using in vitro models (cell lines, primary cells, tissues, etc.). Develop approaches to validate proximity at the membrane using techniques such as proximity ligation assays (PLA), Alphascreen/AlphaLISA, and co-immunoprecipitation assays. Develop high throughput copy number analysis and receptor quantification assays using flow cytometry. Apply proximity labeling, cell surface enrichment, and related proteomics efforts for target validation and nomination studies. Support target validation using tag-based approaches and cell line engineering. Use cutting-edge software tools and collaborate with bioinformatics to analyze and interpret target discovery proteomics datasets. Collaborate across multidisciplinary teams to drive integrated target discovery, validation and functionalization efforts. Present findings internally and externally through team meetings, conferences, and peer-reviewed publications; maintain detailed electronic lab notebooks and experimental records. Qualifications
Basic Qualifications: Doctorate degree or Master’s degree and 2 years of relevant scientific experience or Bachelor’s degree and 4 years of relevant scientific experience Preferred Qualifications: Expertise in proximity labeling proteomics platforms and target validation using flow cytometry, biochemical and imaging-based techniques. Expertise in cellular proximity-based assays like PLA and Alphascreen/AlphaLISA technology. Experience in cell line generation and overexpression systems (e.g., lentiviral delivery) and functional validation of targets using cell-based assays. Experience working with large molecule therapeutics or hybrid modalities such as bispecific antibodies, T-cell engagers, or antibody-drug conjugates (ADCs). Familiarity with high-throughput automation platforms (e.g., Agilent Bravo), high-content imaging platforms and analysis software. Track record of scientific innovation as demonstrated by publications, patents, and/or conference presentations. Demonstrated ability to work collaboratively in fast-paced, multidisciplinary teams. Excellent verbal, written, and organizational skills. What you can expect from us
We offer professional and personal growth and well-being support, including competitive benefits and a collaborative culture. The annual salary range is posted; actual salary varies based on skills, experience, and qualifications. Amgen provides a Total Rewards Plan including health and welfare plans, retirement savings, work/life balance, and career development opportunities, which may include: A comprehensive benefits package with retirement and savings plan contributions, medical/dental/vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or sales-based incentives for field roles Stock-based long-term incentives Award-winning time-off plans Flexible work models, including remote and hybrid options where possible Apply now and make a lasting impact with Amgen. Visit careers.amgen.com to apply. Equal Opportunity and Accommodation
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will provide reasonable accommodation to participate in the job application or interview process, perform essential job functions, and receive other benefits and privileges of employment. Please contact us to request accommodation. Application deadline: Amgen does not have a set application deadline; we continue accepting applications until a suitable candidate is selected.
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