Edgewise Therapeutics
Vice President, Medical Affairs - Skeletal (EDG-2025067)
Edgewise Therapeutics, All Saints Village, Missouri, United States
Overview
Vice President, Medical Affairs - Skeletal (EDG-2025067) About Edgewise Therapeutics
At Edgewise, we are on a mission to discover new medicines that improve the lives of patients facing serious muscle disease. Our knowledge of muscle biology and biophysics, along with our ability to identify and design muscle-specific precision small molecules, enables us to advance skeletal and cardiac muscle product candidates into the clinic while building a robust pre-clinical pipeline. Our focus is on therapeutics designed to protect and improve muscle health, with the goal of dramatically enhancing the lives of people living with progressive muscle disorders. We have assembled an experienced leadership team to build a global muscle disease biopharmaceutical company. The Position
The Vice President, Medical Affairs is a senior leader responsible for shaping and executing the global Medical Affairs strategy across the organization, with a focus on scientific communications, evidence generation, stakeholder engagement, and operational excellence. Reporting to the Chief Medical Officer, this role provides visionary leadership to cross-functional teams supporting neuromuscular diseases. The VP will oversee a growing Medical Affairs organization, build out key capabilities and infrastructure, and serve as a core member of the R&D and senior leadership teams. The VP will lead scalable processes to ensure scientific integrity, compliance, and alignment with corporate strategy, while serving as a visible external-facing leader with KOLs, investigators, and advocacy groups. Responsibilities
Provide strategic and operational leadership for the global Medical Affairs function, ensuring alignment with corporate goals and evolving portfolio needs. Oversee all aspects of scientific communications, including publication strategy, congress planning, and internal/external education. Build and scale the Medical Affairs function, including the development of key capabilities in scientific engagement and field medical strategy. Establish and maintain high-impact relationships with external stakeholders such as KOLs, investigators, healthcare organizations, and patient advocacy groups. Maintain deep familiarity with the science of the therapeutic landscape. Lead the development and implementation of scientific platforms, core messaging, and communication tools to support clinical development and commercialization efforts. Partner with Clinical Development, Regulatory, Commercial, and Market Access to support integrated evidence generation, lifecycle planning, and strategic decision-making in a near-commercial environment. Ensure Medical Affairs operations are compliant, efficient, and aligned with global best practices, including budget oversight, SOPs, and internal governance processes. Lead, mentor, and grow a high-performing Medical Affairs team, fostering a culture of excellence, collaboration, and accountability. Serve as a strategic advisor to the CMO and other senior executives, contributing medical insight to corporate strategy and investor communications. Read, understand, and comply with all workplace health and safety policies; safe work practices; and company policies and procedures. Perform other duties as assigned by supervisor. Required Education, Experience and Skills
Advanced degree in medicine or life sciences (MD, PhD, PharmD, or equivalent) required. 15+ years of progressive Medical Affairs leadership experience within the pharmaceutical or biotechnology industry. Proven track record of senior management/executive-level leadership, including building and scaling medical affairs teams and infrastructure. Deep expertise in neuromuscular diseases preferred. Demonstrated excellence in medical affairs strategy, scientific communication, publication strategy, and external stakeholder engagement. Strong strategic and analytical thinking, with the ability to align medical objectives with broader business goals. Outstanding interpersonal, leadership, and influencing skills, with the ability to engage effectively across internal and external stakeholders. Experience managing complex budgets, external vendors, and global operational frameworks. Ability to thrive in a fast-paced, high-growth environment and drive organizational change. Position Details
Position Type/Expected Hours of Work: This is a remote position with up to 25% travel. Salary range: $300,000 - $375,000, title and salary commensurate with experience. Benefits
We offer health benefits, a discretionary bonus plan, stock option grants, a stock purchase plan, a 401(k) with match, and paid time off as part of the compensation plan. There is no deadline because the employer accepts applications on an ongoing basis. Edgewise does not accept resumes from recruitment agencies for this position. Please do not send resumes to Edgewise employees or the company location. Edgewise is not responsible for any fees related to unsolicited resumes. Seniority level: Executive Employment type: Full-time Job function: Health Care Provider Note: The following related job postings are listed for reference on the site and do not affect this position.
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Vice President, Medical Affairs - Skeletal (EDG-2025067) About Edgewise Therapeutics
At Edgewise, we are on a mission to discover new medicines that improve the lives of patients facing serious muscle disease. Our knowledge of muscle biology and biophysics, along with our ability to identify and design muscle-specific precision small molecules, enables us to advance skeletal and cardiac muscle product candidates into the clinic while building a robust pre-clinical pipeline. Our focus is on therapeutics designed to protect and improve muscle health, with the goal of dramatically enhancing the lives of people living with progressive muscle disorders. We have assembled an experienced leadership team to build a global muscle disease biopharmaceutical company. The Position
The Vice President, Medical Affairs is a senior leader responsible for shaping and executing the global Medical Affairs strategy across the organization, with a focus on scientific communications, evidence generation, stakeholder engagement, and operational excellence. Reporting to the Chief Medical Officer, this role provides visionary leadership to cross-functional teams supporting neuromuscular diseases. The VP will oversee a growing Medical Affairs organization, build out key capabilities and infrastructure, and serve as a core member of the R&D and senior leadership teams. The VP will lead scalable processes to ensure scientific integrity, compliance, and alignment with corporate strategy, while serving as a visible external-facing leader with KOLs, investigators, and advocacy groups. Responsibilities
Provide strategic and operational leadership for the global Medical Affairs function, ensuring alignment with corporate goals and evolving portfolio needs. Oversee all aspects of scientific communications, including publication strategy, congress planning, and internal/external education. Build and scale the Medical Affairs function, including the development of key capabilities in scientific engagement and field medical strategy. Establish and maintain high-impact relationships with external stakeholders such as KOLs, investigators, healthcare organizations, and patient advocacy groups. Maintain deep familiarity with the science of the therapeutic landscape. Lead the development and implementation of scientific platforms, core messaging, and communication tools to support clinical development and commercialization efforts. Partner with Clinical Development, Regulatory, Commercial, and Market Access to support integrated evidence generation, lifecycle planning, and strategic decision-making in a near-commercial environment. Ensure Medical Affairs operations are compliant, efficient, and aligned with global best practices, including budget oversight, SOPs, and internal governance processes. Lead, mentor, and grow a high-performing Medical Affairs team, fostering a culture of excellence, collaboration, and accountability. Serve as a strategic advisor to the CMO and other senior executives, contributing medical insight to corporate strategy and investor communications. Read, understand, and comply with all workplace health and safety policies; safe work practices; and company policies and procedures. Perform other duties as assigned by supervisor. Required Education, Experience and Skills
Advanced degree in medicine or life sciences (MD, PhD, PharmD, or equivalent) required. 15+ years of progressive Medical Affairs leadership experience within the pharmaceutical or biotechnology industry. Proven track record of senior management/executive-level leadership, including building and scaling medical affairs teams and infrastructure. Deep expertise in neuromuscular diseases preferred. Demonstrated excellence in medical affairs strategy, scientific communication, publication strategy, and external stakeholder engagement. Strong strategic and analytical thinking, with the ability to align medical objectives with broader business goals. Outstanding interpersonal, leadership, and influencing skills, with the ability to engage effectively across internal and external stakeholders. Experience managing complex budgets, external vendors, and global operational frameworks. Ability to thrive in a fast-paced, high-growth environment and drive organizational change. Position Details
Position Type/Expected Hours of Work: This is a remote position with up to 25% travel. Salary range: $300,000 - $375,000, title and salary commensurate with experience. Benefits
We offer health benefits, a discretionary bonus plan, stock option grants, a stock purchase plan, a 401(k) with match, and paid time off as part of the compensation plan. There is no deadline because the employer accepts applications on an ongoing basis. Edgewise does not accept resumes from recruitment agencies for this position. Please do not send resumes to Edgewise employees or the company location. Edgewise is not responsible for any fees related to unsolicited resumes. Seniority level: Executive Employment type: Full-time Job function: Health Care Provider Note: The following related job postings are listed for reference on the site and do not affect this position.
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