Johnson & Johnson Innovative Medicine
Senior Scientist, Medicinal Chemistry
Johnson & Johnson Innovative Medicine, San Diego, California, United States, 92189
At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal.
Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.
About Innovative Medicine: Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
Job Description
We are searching for the best talent for a Senior Scientist, Medicinal Chemistry to be located in San Diego, CA. The Discovery Sciences group is committed to the delivery of high-quality drug candidates working with all six Janssen Therapeutic Areas (TAs). This mission requires deep scientific expertise in a number of disciplines including chemistry, cellular and molecular pharmacology, enzymology, and screening technologies coupled with an ability to work collaboratively with internal and external partners. We are seeking experienced medicinal chemists with outstanding organic synthesis expertise to advance small molecule drug discovery programs toward the clinic, with a focus on generating therapeutics employing targeted degradation strategies. Responsibilities
Maintaining a high level of productivity in the laboratory setting Design and synthesis of chimeric targeted degraders and related resources to enable both general platform and individual program advancement Developing and executing clear synthetic strategies towards complex molecules using state-of-the-art synthetic methodologies Independently designing and synthesizing drug-like molecules utilizing medicinal chemistry knowledge and an understanding of ADME, pharmacokinetics and optimal physicochemical properties Collaboratively supporting the advancement of compounds through in vitro and in vivo studies to identify development candidates Collaboration with structure-based design groups to impact rational design of molecules Generating novel, testable hypotheses to enable clear decision making Contributing to defining scientific strategies and goals within a project team setting Presenting data and reports on project status at individual, group, and departmental meetings Drafting, executing and serving as lead author on research published in peer reviewed journals, and presenting work at scientific conferences Qualifications
PhD in synthetic organic or medicinal chemistry is required with at least 3 years of experience at a pharmaceutical company in medicinal chemistry, performing progressively advanced duties beyond the Scientist level Postdoctoral experience is preferred Strong track record of achievement in the synthesis of complex molecules and/or synthetic methodology development, with deep knowledge of modern synthetic & analytical techniques. Proven track record of scientific contributions including peer reviewed publications, patents and presentations. Experience with computational chemistry methods and biophysical techniques such as X-ray crystallography is preferred Independent thinking and the ability to effectively collaborate in a highly matrixed environment. Experience with targeted protein degrader based medicinal chemistry programs is preferred Excellent oral and written communication skills, including preparation of presentations. Up to 5% travel is required. Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. The anticipated base pay range for this position is: $105,000 to $169,050
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We are searching for the best talent for a Senior Scientist, Medicinal Chemistry to be located in San Diego, CA. The Discovery Sciences group is committed to the delivery of high-quality drug candidates working with all six Janssen Therapeutic Areas (TAs). This mission requires deep scientific expertise in a number of disciplines including chemistry, cellular and molecular pharmacology, enzymology, and screening technologies coupled with an ability to work collaboratively with internal and external partners. We are seeking experienced medicinal chemists with outstanding organic synthesis expertise to advance small molecule drug discovery programs toward the clinic, with a focus on generating therapeutics employing targeted degradation strategies. Responsibilities
Maintaining a high level of productivity in the laboratory setting Design and synthesis of chimeric targeted degraders and related resources to enable both general platform and individual program advancement Developing and executing clear synthetic strategies towards complex molecules using state-of-the-art synthetic methodologies Independently designing and synthesizing drug-like molecules utilizing medicinal chemistry knowledge and an understanding of ADME, pharmacokinetics and optimal physicochemical properties Collaboratively supporting the advancement of compounds through in vitro and in vivo studies to identify development candidates Collaboration with structure-based design groups to impact rational design of molecules Generating novel, testable hypotheses to enable clear decision making Contributing to defining scientific strategies and goals within a project team setting Presenting data and reports on project status at individual, group, and departmental meetings Drafting, executing and serving as lead author on research published in peer reviewed journals, and presenting work at scientific conferences Qualifications
PhD in synthetic organic or medicinal chemistry is required with at least 3 years of experience at a pharmaceutical company in medicinal chemistry, performing progressively advanced duties beyond the Scientist level Postdoctoral experience is preferred Strong track record of achievement in the synthesis of complex molecules and/or synthetic methodology development, with deep knowledge of modern synthetic & analytical techniques. Proven track record of scientific contributions including peer reviewed publications, patents and presentations. Experience with computational chemistry methods and biophysical techniques such as X-ray crystallography is preferred Independent thinking and the ability to effectively collaborate in a highly matrixed environment. Experience with targeted protein degrader based medicinal chemistry programs is preferred Excellent oral and written communication skills, including preparation of presentations. Up to 5% travel is required. Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. The anticipated base pay range for this position is: $105,000 to $169,050
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