The Chan Zuckerberg Biohub, Inc.
Computational Biologist, CRISPR Informatics (Biohub SF)
The Chan Zuckerberg Biohub, Inc., San Francisco, California, United States, 94199
Computational Biologist, CRISPR Informatics (Biohub SF)
The Chan Zuckerberg Biohub San Francisco (CZ Biohub SF) is an independent nonprofit research institute that brings together three powerhouse universities - Stanford, UC Berkeley, and UC San Francisco - into a single collaborative technology and discovery engine. CZ Biohub SF itself supports some of the brightest, boldest engineers, data scientists, and biomedical researchers to investigate the fundamental mechanisms underlying disease and develop new technologies that will lead to actionable diagnostics and effective therapies. Our Vision
We pursue large scientific challenges that cannot be pursued in conventional environments We enable individual investigators to pursue their riskiest and most innovative ideas The technologies developed at CZ Biohub San Francisco facilitate research by scientists and clinicians at our home institutions and beyond Diversity of thought, ideas, and perspectives are at the heart of CZ Biohub Network and enable disruptive innovation and scholarly excellence. The Opportunity
We’re a cross-disciplinary institute on an audacious quest: to chart the dynamic architecture of cells at a scale and resolution once thought impossible. By uniting biology, engineering, and computation, we invent the breakthrough technologies this vision demands. We’re gearing up for our most ambitious push yet, as our next Computational Biologist you will architect and build the computational backbone that powers our upcoming large scale CRISPR experiments in both human cells, organoids and even whole organisms (zebrafish). What You'll Do
Architect, build and maintain computation workflows for CRISPR design and edit-outcome analysis. Analyze genome-scale CRISPR perturbation datasets and identify emergent gene-function and pathway networks. Work with molecular biologists, imaging scientists, and software engineers to plan large scale CRISPR experiments and interpret results. Package, document and rigorously test code, computational pipelines and datasets for open-source release. Author publications and present research findings at conferences. What You'll Bring
Ph.D. in Computational Biology, Bioinformatics, Bioengineering, Genomics or a related discipline. 2+ years of deep, current knowledge of CRISPR genome-engineering technologies and the underlying molecular biology. Proven track record of developing computational pipelines for CRISPR design and edit-outcome analysis. Fluency in Python (or similar), experience with workflow management frameworks, and strong software engineering practices. A collaborative, team-focused mindset coupled with outstanding communication skills. Nice to have - experience in analyzing CRISPR perturbations datasets at single cell resolution, designing bioinformatics pipelines, utilizing high-performance computing systems, and prior contributions to open-source projects. Compensation
The San Francisco, CA base pay range for a new hire in this role is $108,000.00 - $149,000.00 and $132,000.00 - $182,000.00. Benefits for the Whole You
We offer a wide range of benefits to support the people who make all we do possible, including a generous employer match on employee 401(k) contributions, paid time off to volunteer, and relocation support. CZ Biohub is an Equal Opportunity Employer and does not discriminate on the basis of any protected group status under any applicable law.
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The Chan Zuckerberg Biohub San Francisco (CZ Biohub SF) is an independent nonprofit research institute that brings together three powerhouse universities - Stanford, UC Berkeley, and UC San Francisco - into a single collaborative technology and discovery engine. CZ Biohub SF itself supports some of the brightest, boldest engineers, data scientists, and biomedical researchers to investigate the fundamental mechanisms underlying disease and develop new technologies that will lead to actionable diagnostics and effective therapies. Our Vision
We pursue large scientific challenges that cannot be pursued in conventional environments We enable individual investigators to pursue their riskiest and most innovative ideas The technologies developed at CZ Biohub San Francisco facilitate research by scientists and clinicians at our home institutions and beyond Diversity of thought, ideas, and perspectives are at the heart of CZ Biohub Network and enable disruptive innovation and scholarly excellence. The Opportunity
We’re a cross-disciplinary institute on an audacious quest: to chart the dynamic architecture of cells at a scale and resolution once thought impossible. By uniting biology, engineering, and computation, we invent the breakthrough technologies this vision demands. We’re gearing up for our most ambitious push yet, as our next Computational Biologist you will architect and build the computational backbone that powers our upcoming large scale CRISPR experiments in both human cells, organoids and even whole organisms (zebrafish). What You'll Do
Architect, build and maintain computation workflows for CRISPR design and edit-outcome analysis. Analyze genome-scale CRISPR perturbation datasets and identify emergent gene-function and pathway networks. Work with molecular biologists, imaging scientists, and software engineers to plan large scale CRISPR experiments and interpret results. Package, document and rigorously test code, computational pipelines and datasets for open-source release. Author publications and present research findings at conferences. What You'll Bring
Ph.D. in Computational Biology, Bioinformatics, Bioengineering, Genomics or a related discipline. 2+ years of deep, current knowledge of CRISPR genome-engineering technologies and the underlying molecular biology. Proven track record of developing computational pipelines for CRISPR design and edit-outcome analysis. Fluency in Python (or similar), experience with workflow management frameworks, and strong software engineering practices. A collaborative, team-focused mindset coupled with outstanding communication skills. Nice to have - experience in analyzing CRISPR perturbations datasets at single cell resolution, designing bioinformatics pipelines, utilizing high-performance computing systems, and prior contributions to open-source projects. Compensation
The San Francisco, CA base pay range for a new hire in this role is $108,000.00 - $149,000.00 and $132,000.00 - $182,000.00. Benefits for the Whole You
We offer a wide range of benefits to support the people who make all we do possible, including a generous employer match on employee 401(k) contributions, paid time off to volunteer, and relocation support. CZ Biohub is an Equal Opportunity Employer and does not discriminate on the basis of any protected group status under any applicable law.
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