Merck
Senior Specialist, Quantitative Pharmacology and Pharmacometrics - Infectious Di
Merck, West Point, Pennsylvania, us, 19486
Overview
Senior Specialists in the Infectious Disease and Vaccines group
in the department of Quantitative Pharmacology and Pharmacometrics (QP2) apply quantitative approaches to enable drug-development decision-making from drug discovery through approval. Responsibilities
Senior Specialists will work in collaborative teams and with more experienced scientists across disciplines, and are expected to have or develop expertise in one or more areas necessary to perform the primary responsibilities of the role including: Applying quantitative approaches to develop and implement translational clinical pharmacokinetics and pharmacodynamics of new drug and vaccine candidates Developing and executing pharmacokinetics and pharmacodynamics modelling approaches, such as noncompartmental analysis, population pharmacokinetic, exposure-response, quantitative system pharmacology, viral dynamics, model-based meta-analysis, and other model-based analyses Perform clinical trial simulations to inform dose selection and go/no-go decisions Serve as a QP2 representative while being mentored by QP2 senior staff on drug and vaccine development teams to manage functional deliverables for assigned programs On the job, you will begin to develop a comprehensive understanding of global regulatory expectations of drug and vaccine development, including clinical trial design, clinical pharmacology, biomarker plans, and model-based drug development approaches. You will also develop leadership skills in areas such as mentoring, managing a program, project, or initiative. Collaboration within the group and with other functional areas, as well as with external vendors and partners, to create an aligned, quantitative framework to impact decisions of drug development teams is also crucial. The ideal candidate is collaborative and eager to learn. Excellent communication skills both written and verbal are required, including the ability to clearly present scientific data in cross functional group settings. QP2 offers a unique opportunity to accelerate your professional career as a quantitative drug developer taking advantage of our end-to-end pipeline support in one of the world’s most research-intensive biopharmaceutical companies. Minimum Required Education
A Ph.D. or equivalent degree - OR- a PharmD or equivalent degree with at least two years of experience - OR- a MS or equivalent degree with at least four years of experience, where “experience” means having a record of increasing responsibility and independence in a similar role in pharmaceutical drug development or academia An educational background in PK/PD, pharmaceutical sciences, pharmacometrics, mathematics, statistics/ biostatistics, computational biology/chemistry, chemical/biomedical engineering, or a related field. Required Experience And Skills
Proficiency in R, NONMEM, Matlab, Python, or a similar programming language Proficiency in written and verbal communication Preferred Experience And Skills
Knowledge of infectious diseases Experience performing population PK and/or PK/PD analyses Experience with standard pharmacometrics software (e.g. NONMEM, Monolix, Phoenix.) Skills in experimental design, mathematical problem solving, critical data analysis/interpretation, and statistics Scientific understanding of ADME and biopharmaceutic properties of biologics, small molecules, or non-traditional therapeutics R equired and helpful: Clinical Pharmacology, Data Modeling, Data Visualization, Drug Development, Drug Discovery Process, Pharmacometrics, PKPD Modeling, Programming Languages, Therapeutics Preferred Skills : ADME, Biologics, Experiential Design, Infectious Disease, Nonlinear Mixed Effects Modeling (NONMEM), NONMEM, Phoenix WinNonlin, Regulatory Approvals, Small Molecules, Vaccine Research Other Information : US And Puerto Rico Residents Only. Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. Legal and Compliance
As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit EEOC Know Your Rights and EEOC GINA Supplement. We are proud to be a company that embraces diversity and inclusion and encourage collaboration across diverse perspectives. U.S. Hybrid Work Model: Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid schedule unless otherwise specified. This includes three on-site days per week, with Friday remote, subject to business needs. This does not apply to roles designated as remote or certain on-site requirements. Salary range: $126,500.00 - $199,100.00. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. Benefits include medical, dental, vision, retirement, paid holidays, vacation, and sick days. More information at Merck compensation and benefits. Application: You can apply through Merck Careers. The posting end date is 10/26/2025. Referrals can increase your chances of interviewing.
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Senior Specialists in the Infectious Disease and Vaccines group
in the department of Quantitative Pharmacology and Pharmacometrics (QP2) apply quantitative approaches to enable drug-development decision-making from drug discovery through approval. Responsibilities
Senior Specialists will work in collaborative teams and with more experienced scientists across disciplines, and are expected to have or develop expertise in one or more areas necessary to perform the primary responsibilities of the role including: Applying quantitative approaches to develop and implement translational clinical pharmacokinetics and pharmacodynamics of new drug and vaccine candidates Developing and executing pharmacokinetics and pharmacodynamics modelling approaches, such as noncompartmental analysis, population pharmacokinetic, exposure-response, quantitative system pharmacology, viral dynamics, model-based meta-analysis, and other model-based analyses Perform clinical trial simulations to inform dose selection and go/no-go decisions Serve as a QP2 representative while being mentored by QP2 senior staff on drug and vaccine development teams to manage functional deliverables for assigned programs On the job, you will begin to develop a comprehensive understanding of global regulatory expectations of drug and vaccine development, including clinical trial design, clinical pharmacology, biomarker plans, and model-based drug development approaches. You will also develop leadership skills in areas such as mentoring, managing a program, project, or initiative. Collaboration within the group and with other functional areas, as well as with external vendors and partners, to create an aligned, quantitative framework to impact decisions of drug development teams is also crucial. The ideal candidate is collaborative and eager to learn. Excellent communication skills both written and verbal are required, including the ability to clearly present scientific data in cross functional group settings. QP2 offers a unique opportunity to accelerate your professional career as a quantitative drug developer taking advantage of our end-to-end pipeline support in one of the world’s most research-intensive biopharmaceutical companies. Minimum Required Education
A Ph.D. or equivalent degree - OR- a PharmD or equivalent degree with at least two years of experience - OR- a MS or equivalent degree with at least four years of experience, where “experience” means having a record of increasing responsibility and independence in a similar role in pharmaceutical drug development or academia An educational background in PK/PD, pharmaceutical sciences, pharmacometrics, mathematics, statistics/ biostatistics, computational biology/chemistry, chemical/biomedical engineering, or a related field. Required Experience And Skills
Proficiency in R, NONMEM, Matlab, Python, or a similar programming language Proficiency in written and verbal communication Preferred Experience And Skills
Knowledge of infectious diseases Experience performing population PK and/or PK/PD analyses Experience with standard pharmacometrics software (e.g. NONMEM, Monolix, Phoenix.) Skills in experimental design, mathematical problem solving, critical data analysis/interpretation, and statistics Scientific understanding of ADME and biopharmaceutic properties of biologics, small molecules, or non-traditional therapeutics R equired and helpful: Clinical Pharmacology, Data Modeling, Data Visualization, Drug Development, Drug Discovery Process, Pharmacometrics, PKPD Modeling, Programming Languages, Therapeutics Preferred Skills : ADME, Biologics, Experiential Design, Infectious Disease, Nonlinear Mixed Effects Modeling (NONMEM), NONMEM, Phoenix WinNonlin, Regulatory Approvals, Small Molecules, Vaccine Research Other Information : US And Puerto Rico Residents Only. Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. Legal and Compliance
As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit EEOC Know Your Rights and EEOC GINA Supplement. We are proud to be a company that embraces diversity and inclusion and encourage collaboration across diverse perspectives. U.S. Hybrid Work Model: Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid schedule unless otherwise specified. This includes three on-site days per week, with Friday remote, subject to business needs. This does not apply to roles designated as remote or certain on-site requirements. Salary range: $126,500.00 - $199,100.00. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. Benefits include medical, dental, vision, retirement, paid holidays, vacation, and sick days. More information at Merck compensation and benefits. Application: You can apply through Merck Careers. The posting end date is 10/26/2025. Referrals can increase your chances of interviewing.
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