Virginia Polytechnic Institute and State University (VT)
Research Scientist
Virginia Polytechnic Institute and State University (VT), Olympia, Washington, United States
Overview
The Sahoo Lab is seeking a Research Scientist to help develop and lead our research program focused on the genetic and functional mechanisms driving bone marrow failure, clonal hematopoiesis, and progression to MDS/AML. The Research Scientist will have the opportunity to pursue an independent project while also contributing to collaborative efforts across the group, including mentoring and training junior scientists. Our lab uses patient-derived samples, iPSC models, CRISPR-based genome editing, single-cell multi-omics, and mouse disease models to uncover how germline and acquired genetic changes including mutations, and chromosomal aneuploidy shape hematopoietic stem cell fate and leukemogenesis. Available projects include Germline predisposition to MDS/AML, Chromosome 7 aneuploidy syndromes, and Clonal evolution and therapeutic vulnerabilities. The Research Scientist will have access to Virginia Tech and Children’s National Hospital resources, core facilities, and seminars, and will be provided strong opportunities for career growth and development. This is an exciting opportunity to play a foundational role in shaping a new lab at the Research and Innovation Campus in Washington, DC.
Responsibilities
Develop and lead a research program focused on genetic and functional mechanisms driving bone marrow failure, clonal hematopoiesis, and progression to MDS/AML. Pursue an independent project while contributing to collaborative efforts within the group; mentor and train junior scientists. Design and execute experiments using patient-derived samples, iPSC models, CRISPR-based genome editing, single-cell multi-omics, and mouse disease models. Investigate how germline and acquired genetic changes, including mutations and chromosomal aneuploidy, influence hematopoietic stem cell fate and leukemogenesis. Engage with available projects such as germline predisposition to MDS/AML, chromosome 7 aneuploidy syndromes, and clonal evolution to identify therapeutic targets. Utilize core facilities and participate in seminars; contribute to career growth, leadership training, networking, conference participation, and skill development. Contribute to shaping a new lab environment and participate in leadership activities at the Research and Innovation Campus in Washington, DC.
Qualifications
Ph.D. in a biological science such as hematology, genetics, molecular biology, or cancer biology Postdoctoral research experience with a strong publication record Strong expertise in experimental design and execution Proficiency in wet lab techniques, including molecular biology and mammalian cell culture Hands-on experience with primary cells such as iPSCs and hematopoietic stem cells Experience with CRISPR-based genome editing and functional screens Self-motivated, creative, and detail-oriented researcher Excellent organizational and time management skills Ability to work independently and as part of a collaborative team Experience mentoring or training students and/or research staff Excellent communication skills
Preferred Qualifications
Experience with mouse models of hematopoiesis or cancer Familiarity with single-cell multi-omics approaches Analysis of large-scale genomic and/or transcriptomics data sets
Additional Details
Overtime Status: Exempt; Not eligible for overtime Appointment Type: Restricted Salary Information: Commensurate with experience Review Date: 10/21/25 Additional Information: The successful candidate will be required to have a criminal conviction check.
About Virginia Tech
Dedicated to its motto, Ut Prosim (That I May Serve), Virginia Tech pushes the boundaries of knowledge by taking a hands-on, transdisciplinary approach to preparing scholars to be leaders and problem-solvers. A comprehensive land-grant institution that enhances the quality of life in Virginia and throughout the world, Virginia Tech is an inclusive community dedicated to knowledge, discovery, and creativity. The university offers more than 280 majors to a diverse enrollment of more than 36,000 undergraduate, graduate, and professional students in eight undergraduate colleges, a school of medicine, a veterinary medicine college, Graduate School, and Honors College. The university has a significant presence across Virginia, including Blacksburg, the greater Washington, D.C. area, the Health Sciences and Technology Campus in Roanoke, sites in Newport News and Richmond, and numerous Extension offices and research institutes. A leading global research institution, Virginia Tech conducts more than $650 million in research annually. Virginia Tech endorses and encourages participation in professional development opportunities and university shared governance. These contributions provide important representation and perspective, along with opportunities for unique and impactful professional development. Virginia Tech does not discriminate against employees, students, or applicants on the basis of age, color, disability, sex (including pregnancy), gender, gender identity, gender expression, genetic information, ethnicity or national origin, political affiliation, race, religion, sexual orientation, or military status, or otherwise discriminate against employees or applicants who inquire about, discuss, or disclose their compensation or the compensation of other employees or applicants, or on any other basis protected by law. If you are an individual with a disability and desire an accommodation, please contact Brittany Shelton at sheltb@vtc.vt.edu during regular business hours at least 10 business days prior to the event. Advertised:
October 7, 2025
#J-18808-Ljbffr
The Sahoo Lab is seeking a Research Scientist to help develop and lead our research program focused on the genetic and functional mechanisms driving bone marrow failure, clonal hematopoiesis, and progression to MDS/AML. The Research Scientist will have the opportunity to pursue an independent project while also contributing to collaborative efforts across the group, including mentoring and training junior scientists. Our lab uses patient-derived samples, iPSC models, CRISPR-based genome editing, single-cell multi-omics, and mouse disease models to uncover how germline and acquired genetic changes including mutations, and chromosomal aneuploidy shape hematopoietic stem cell fate and leukemogenesis. Available projects include Germline predisposition to MDS/AML, Chromosome 7 aneuploidy syndromes, and Clonal evolution and therapeutic vulnerabilities. The Research Scientist will have access to Virginia Tech and Children’s National Hospital resources, core facilities, and seminars, and will be provided strong opportunities for career growth and development. This is an exciting opportunity to play a foundational role in shaping a new lab at the Research and Innovation Campus in Washington, DC.
Responsibilities
Develop and lead a research program focused on genetic and functional mechanisms driving bone marrow failure, clonal hematopoiesis, and progression to MDS/AML. Pursue an independent project while contributing to collaborative efforts within the group; mentor and train junior scientists. Design and execute experiments using patient-derived samples, iPSC models, CRISPR-based genome editing, single-cell multi-omics, and mouse disease models. Investigate how germline and acquired genetic changes, including mutations and chromosomal aneuploidy, influence hematopoietic stem cell fate and leukemogenesis. Engage with available projects such as germline predisposition to MDS/AML, chromosome 7 aneuploidy syndromes, and clonal evolution to identify therapeutic targets. Utilize core facilities and participate in seminars; contribute to career growth, leadership training, networking, conference participation, and skill development. Contribute to shaping a new lab environment and participate in leadership activities at the Research and Innovation Campus in Washington, DC.
Qualifications
Ph.D. in a biological science such as hematology, genetics, molecular biology, or cancer biology Postdoctoral research experience with a strong publication record Strong expertise in experimental design and execution Proficiency in wet lab techniques, including molecular biology and mammalian cell culture Hands-on experience with primary cells such as iPSCs and hematopoietic stem cells Experience with CRISPR-based genome editing and functional screens Self-motivated, creative, and detail-oriented researcher Excellent organizational and time management skills Ability to work independently and as part of a collaborative team Experience mentoring or training students and/or research staff Excellent communication skills
Preferred Qualifications
Experience with mouse models of hematopoiesis or cancer Familiarity with single-cell multi-omics approaches Analysis of large-scale genomic and/or transcriptomics data sets
Additional Details
Overtime Status: Exempt; Not eligible for overtime Appointment Type: Restricted Salary Information: Commensurate with experience Review Date: 10/21/25 Additional Information: The successful candidate will be required to have a criminal conviction check.
About Virginia Tech
Dedicated to its motto, Ut Prosim (That I May Serve), Virginia Tech pushes the boundaries of knowledge by taking a hands-on, transdisciplinary approach to preparing scholars to be leaders and problem-solvers. A comprehensive land-grant institution that enhances the quality of life in Virginia and throughout the world, Virginia Tech is an inclusive community dedicated to knowledge, discovery, and creativity. The university offers more than 280 majors to a diverse enrollment of more than 36,000 undergraduate, graduate, and professional students in eight undergraduate colleges, a school of medicine, a veterinary medicine college, Graduate School, and Honors College. The university has a significant presence across Virginia, including Blacksburg, the greater Washington, D.C. area, the Health Sciences and Technology Campus in Roanoke, sites in Newport News and Richmond, and numerous Extension offices and research institutes. A leading global research institution, Virginia Tech conducts more than $650 million in research annually. Virginia Tech endorses and encourages participation in professional development opportunities and university shared governance. These contributions provide important representation and perspective, along with opportunities for unique and impactful professional development. Virginia Tech does not discriminate against employees, students, or applicants on the basis of age, color, disability, sex (including pregnancy), gender, gender identity, gender expression, genetic information, ethnicity or national origin, political affiliation, race, religion, sexual orientation, or military status, or otherwise discriminate against employees or applicants who inquire about, discuss, or disclose their compensation or the compensation of other employees or applicants, or on any other basis protected by law. If you are an individual with a disability and desire an accommodation, please contact Brittany Shelton at sheltb@vtc.vt.edu during regular business hours at least 10 business days prior to the event. Advertised:
October 7, 2025
#J-18808-Ljbffr