Boehringer Ingelheim
SR Principal/ Principal Scientist, Oncology Pharmacology, Immunology
Boehringer Ingelheim, Ridgefield, Connecticut, us, 06877
Overview
A key scientific member and leader within the Oncology Research group at Boehringer Ingelheim’s US research facility in Ridgefield, CT. The successful candidate will spearhead research activities focusing on biology- and target-specific modeling and mechanism of action (MOA) interrogation to support in vivo target validation, candidate selection and biomarker discovery of novel cancer immune reprogramming therapeutic concepts for Boehringer’s global Oncology Research TA. As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies’ success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, diversity and inclusion, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim’s high regard for our employees. Duties & Responsibilities
Functioning as In vivo Pharmacology Lead on portfolio projects to generate data packages for target validation, compound screens, efficacy, human dose estimation, and candidate selection, as well as to explore MOA and PD biomarkers for both large molecules and small molecule compounds Develop and refine existing in vivo modeling systems to evaluate cancer immune reprogramming concepts (NTCs) with increased clinical relevance Collaborate with NTC project leads (Ridgefield or Vienna based team members in Oncology Research) to develop novel modeling methodologies to assess target- and pathway-specific immune reprogramming effects of NTCs in vivo and ex vivo Collaborate with Project Teams from other disciplines located in Ridgefield and globally (Austria and Switzerland) to enable key milestone movements and program decisions on NTCs, while synergizing effectively with the global in vivo pharmacology group of Oncology Research in Vienna, Austria Independently responsible for authoring IACUC approved animal protocols and ensuring their authorization, compliance and maintenance Train and direct research scientists, including supervising responsibilities, mentoring, developing (and recruiting) scientific staff. Ensure team maintains compliance of IACUC protocols and health and safety regulations Prepare and review technical and research reports for internal and external use. Deliver scientific presentations for internal/external use. Act as an experienced resource in project teams with clear and professional verbal and written communication Keep abreast of relevant literature, expand scientific/technical knowledge, publish in peer‑reviewed journals and present at internationally recognized scientific conferences Requirements
Principal Scientist
Ph.D. from an accredited institution, or equivalent in a relevant field, with five-plus (5+) years of experience in addition to experience in lab management Proven track record of supervising scientists and students Strong understanding of immunological principles through experience in cancer immunology, inflammation, or autoimmunity, with exceptional hands-on in vivo experimental skills Strong understanding of principles of cancer immunology and prior hands-on experience running mouse models of immunotherapy (e.g. syngeneic mouse tumor models, humanized tumor models) is highly desired Familiarity with Institutional animal ethics governance bodies (USA IACUC or European FELASA) through active responsibilities on animal licenses or protocols as Study Director or Principal Investigator A demonstrated track record of independent research and peer‑reviewed publications in immunology Excellent oral and written communication skills, with the ability to propose, articulate, evaluate and defend scientific ideas and data Ability to mentor and develop scientific staff Ability and willingness to work effectively in a highly collaborative research environment with colleagues in Austria, Germany, Switzerland and the USA including occasional travel to global research sites Senior Principal Scientist
Ph.D. from an accredited institution, or equivalent in a relevant field, with seven-plus (7+) years of experience in addition to experience in lab management Strong leadership of a team with demonstrated influence on cross-functional, matrixed team environment Prior hands-on experience generating in vivo models to assess aspects of cancer immune reprogramming Experience with efficacy and PK/PD and biomarker studies is a plus Principal Investigator on a USA IACUC protocol or European FELASA documents is required Compensation
This position, Principal Scientist, offers a base salary typically between $140,000.00 and $222,000.00. The position may be eligible for a role-specific variable or performance-based bonus and/or other compensation elements. For an overview of our benefits please click here. Eligibility Requirements
Must be legally authorized to work in the United States without restriction at commencement of role Must be willing to take a drug test and post-offer physical (if required) Must be 18 years of age or older Why Boehringer Ingelheim?
With us, you can develop your own path in a company with a culture that values differences as strengths and drives to make millions of lives better. We support your development and offer programs to ensure health and wellbeing are looked after as we invest in global accessibility to healthcare. By being part of a team that is constantly innovating, you’ll help transform lives for generations.
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A key scientific member and leader within the Oncology Research group at Boehringer Ingelheim’s US research facility in Ridgefield, CT. The successful candidate will spearhead research activities focusing on biology- and target-specific modeling and mechanism of action (MOA) interrogation to support in vivo target validation, candidate selection and biomarker discovery of novel cancer immune reprogramming therapeutic concepts for Boehringer’s global Oncology Research TA. As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies’ success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, diversity and inclusion, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim’s high regard for our employees. Duties & Responsibilities
Functioning as In vivo Pharmacology Lead on portfolio projects to generate data packages for target validation, compound screens, efficacy, human dose estimation, and candidate selection, as well as to explore MOA and PD biomarkers for both large molecules and small molecule compounds Develop and refine existing in vivo modeling systems to evaluate cancer immune reprogramming concepts (NTCs) with increased clinical relevance Collaborate with NTC project leads (Ridgefield or Vienna based team members in Oncology Research) to develop novel modeling methodologies to assess target- and pathway-specific immune reprogramming effects of NTCs in vivo and ex vivo Collaborate with Project Teams from other disciplines located in Ridgefield and globally (Austria and Switzerland) to enable key milestone movements and program decisions on NTCs, while synergizing effectively with the global in vivo pharmacology group of Oncology Research in Vienna, Austria Independently responsible for authoring IACUC approved animal protocols and ensuring their authorization, compliance and maintenance Train and direct research scientists, including supervising responsibilities, mentoring, developing (and recruiting) scientific staff. Ensure team maintains compliance of IACUC protocols and health and safety regulations Prepare and review technical and research reports for internal and external use. Deliver scientific presentations for internal/external use. Act as an experienced resource in project teams with clear and professional verbal and written communication Keep abreast of relevant literature, expand scientific/technical knowledge, publish in peer‑reviewed journals and present at internationally recognized scientific conferences Requirements
Principal Scientist
Ph.D. from an accredited institution, or equivalent in a relevant field, with five-plus (5+) years of experience in addition to experience in lab management Proven track record of supervising scientists and students Strong understanding of immunological principles through experience in cancer immunology, inflammation, or autoimmunity, with exceptional hands-on in vivo experimental skills Strong understanding of principles of cancer immunology and prior hands-on experience running mouse models of immunotherapy (e.g. syngeneic mouse tumor models, humanized tumor models) is highly desired Familiarity with Institutional animal ethics governance bodies (USA IACUC or European FELASA) through active responsibilities on animal licenses or protocols as Study Director or Principal Investigator A demonstrated track record of independent research and peer‑reviewed publications in immunology Excellent oral and written communication skills, with the ability to propose, articulate, evaluate and defend scientific ideas and data Ability to mentor and develop scientific staff Ability and willingness to work effectively in a highly collaborative research environment with colleagues in Austria, Germany, Switzerland and the USA including occasional travel to global research sites Senior Principal Scientist
Ph.D. from an accredited institution, or equivalent in a relevant field, with seven-plus (7+) years of experience in addition to experience in lab management Strong leadership of a team with demonstrated influence on cross-functional, matrixed team environment Prior hands-on experience generating in vivo models to assess aspects of cancer immune reprogramming Experience with efficacy and PK/PD and biomarker studies is a plus Principal Investigator on a USA IACUC protocol or European FELASA documents is required Compensation
This position, Principal Scientist, offers a base salary typically between $140,000.00 and $222,000.00. The position may be eligible for a role-specific variable or performance-based bonus and/or other compensation elements. For an overview of our benefits please click here. Eligibility Requirements
Must be legally authorized to work in the United States without restriction at commencement of role Must be willing to take a drug test and post-offer physical (if required) Must be 18 years of age or older Why Boehringer Ingelheim?
With us, you can develop your own path in a company with a culture that values differences as strengths and drives to make millions of lives better. We support your development and offer programs to ensure health and wellbeing are looked after as we invest in global accessibility to healthcare. By being part of a team that is constantly innovating, you’ll help transform lives for generations.
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