Lyell Immunopharma
Director/Medical Director, Medical Affairs
Lyell Immunopharma, California, Missouri, United States, 65018
Director/Medical Director, Medical Affairs
Position Summary
The Director / Medical Director, Medical Affairs will contribute to and help lead the execution of Lyell’s Medical Affairs strategy, ensuring alignment with clinical development, regulatory, and other cross-functional objectives. This role requires an advanced degree (M.D., D.O., Ph.D., or Pharm.D.) and strong scientific expertise in oncology or related fields. The successful candidate will serve as a credible medical/scientific voice with external stakeholders while guiding the development of medical initiatives, evidence generation, and scientific engagement. The role will ensure that insights from the medical and scientific community inform Lyell’s programs and will play a critical role in preparing for future product approvals and launches.
Key Responsibilities
Medical Leadership & Scientific Contribution
Provide medical and scientific input into the design and execution of U.S. Medical Affairs plans for lymphoma and solid tumors.
Guide or support study design, recruitment strategies, and protocol refinement in collaboration with Clinical Development.
Gather and integrate clinical and scientific insights from the external community to shape Medical Affairs initiatives.
Conduct and synthesize competitive intelligence to inform strategy, highlight differentiation, and anticipate shifts in the treatment landscape.
External Engagement
Build and sustain relationships with KOLs, investigators, advocacy groups, cooperative groups, and professional societies.
Represent Lyell at major congresses (ASH, ASCO, EHA, ICML), advisory boards, and other scientific forums.
Incorporate insights from clinical practice, scientific advances, and competitor activity into Lyell’s medical planning.
Serve as a trusted external voice for Lyell in medical and scientific exchange.
Medical Excellence
Lead or contribute to the development of medical narratives, scientific platforms, publications, and educational materials.
Draft, review, and/or approve medical and scientific content for compliance, accuracy, and relevance.
Provide training to internal teams to ensure consistency of scientific messaging.
Compliance & Governance
Participate in medical review committees and ensure compliance with FDA/ICH guidelines and Lyell’s governance standards.
Contribute to authorship policies, steering committee charters, and publication planning.
Required Education & Experience
M.D./D.O. (for Medical Director level) or PhD or Pharm.D. (for Director level).
Oncology/hematology specialty or expertise preferred (not required).
6–10 years in the pharmaceutical/biotech industry, with at least 4+ years in Medical Affairs.
Experience in oncology preferred, cell therapy, immuno-oncology, or hematologic malignancies desirable.
Demonstrated experience with study design, clinical development interface, and evidence generation.
Strong background in publications, scientific communications, or external engagement.
Familiarity with U.S. regulatory, compliance, and healthcare environment.
Compensation & Benefits
The salary range for this position is $260,000 to $320,000 annually, with the opportunity to earn an annual bonus. The salary range is an estimate, and the actual salary may vary based on Lyell’s compensation practices and an applicant’s qualifications and experience. Employees are also eligible to participate in Lyell’s Equity Incentive Plan.
Our Employee Benefits program is extensive and includes subsidized medical, dental and vision plans from your first day of employment, FSA, Company provided Life and AD&D Insurance as well as STD and LTD Insurance, ESPP, a 401(k) Plan with Company match, mass transit commuter benefits, cell phone reimbursement and a range of supplemental benefits that you may choose to elect. Our paid time-off benefits currently include 18 days’ vacation, 9 day’s sick leave, 8 observed holidays as well as a floating holiday. We also have a summer and a winter office shutdown.
Equal Employment Opportunity
At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees. Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.
We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply.
#J-18808-Ljbffr
The Director / Medical Director, Medical Affairs will contribute to and help lead the execution of Lyell’s Medical Affairs strategy, ensuring alignment with clinical development, regulatory, and other cross-functional objectives. This role requires an advanced degree (M.D., D.O., Ph.D., or Pharm.D.) and strong scientific expertise in oncology or related fields. The successful candidate will serve as a credible medical/scientific voice with external stakeholders while guiding the development of medical initiatives, evidence generation, and scientific engagement. The role will ensure that insights from the medical and scientific community inform Lyell’s programs and will play a critical role in preparing for future product approvals and launches.
Key Responsibilities
Medical Leadership & Scientific Contribution
Provide medical and scientific input into the design and execution of U.S. Medical Affairs plans for lymphoma and solid tumors.
Guide or support study design, recruitment strategies, and protocol refinement in collaboration with Clinical Development.
Gather and integrate clinical and scientific insights from the external community to shape Medical Affairs initiatives.
Conduct and synthesize competitive intelligence to inform strategy, highlight differentiation, and anticipate shifts in the treatment landscape.
External Engagement
Build and sustain relationships with KOLs, investigators, advocacy groups, cooperative groups, and professional societies.
Represent Lyell at major congresses (ASH, ASCO, EHA, ICML), advisory boards, and other scientific forums.
Incorporate insights from clinical practice, scientific advances, and competitor activity into Lyell’s medical planning.
Serve as a trusted external voice for Lyell in medical and scientific exchange.
Medical Excellence
Lead or contribute to the development of medical narratives, scientific platforms, publications, and educational materials.
Draft, review, and/or approve medical and scientific content for compliance, accuracy, and relevance.
Provide training to internal teams to ensure consistency of scientific messaging.
Compliance & Governance
Participate in medical review committees and ensure compliance with FDA/ICH guidelines and Lyell’s governance standards.
Contribute to authorship policies, steering committee charters, and publication planning.
Required Education & Experience
M.D./D.O. (for Medical Director level) or PhD or Pharm.D. (for Director level).
Oncology/hematology specialty or expertise preferred (not required).
6–10 years in the pharmaceutical/biotech industry, with at least 4+ years in Medical Affairs.
Experience in oncology preferred, cell therapy, immuno-oncology, or hematologic malignancies desirable.
Demonstrated experience with study design, clinical development interface, and evidence generation.
Strong background in publications, scientific communications, or external engagement.
Familiarity with U.S. regulatory, compliance, and healthcare environment.
Compensation & Benefits
The salary range for this position is $260,000 to $320,000 annually, with the opportunity to earn an annual bonus. The salary range is an estimate, and the actual salary may vary based on Lyell’s compensation practices and an applicant’s qualifications and experience. Employees are also eligible to participate in Lyell’s Equity Incentive Plan.
Our Employee Benefits program is extensive and includes subsidized medical, dental and vision plans from your first day of employment, FSA, Company provided Life and AD&D Insurance as well as STD and LTD Insurance, ESPP, a 401(k) Plan with Company match, mass transit commuter benefits, cell phone reimbursement and a range of supplemental benefits that you may choose to elect. Our paid time-off benefits currently include 18 days’ vacation, 9 day’s sick leave, 8 observed holidays as well as a floating holiday. We also have a summer and a winter office shutdown.
Equal Employment Opportunity
At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees. Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.
We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply.
#J-18808-Ljbffr