GSK
Principal Scientist, Discovery DMPK Bioanalytical
GSK, Collegeville, Pennsylvania, United States, 19426
Overview
Join to apply for the
Principal Scientist, Discovery DMPK Bioanalytical
role at
GSK . Are you looking to apply your mass spectrometry skills to solve challenging bioanalytical problems and help drive discovery programs forward, helping patients across the globe? As a Discovery DMPK bioanalyst, you will be part of a team responsible for the analysis of molecules spanning GSK’s portfolio. Using state of the art equipment, we work with compounds at stages from early discovery to development in a fast-paced discovery laboratory environment. In this role you will have opportunities to utilize, challenge, and expand your bioanalytical skill sets for small molecules, oligonucleotides, biologics, and other emerging modalities.
Responsibilities
Within the Discovery DMPK group, utilize lab-bench technical knowledge and apply experience in LC-MS approaches to support GSK’s portfolio deliverables.
Focus on the bioanalytical support of DMPK assays, exploratory biology experiments (e.g., PK-PD), and non-GLP toxicokinetic studies across modalities.
Gain broad experience while also taking deep scientific dives to support challenging analyses; contribute to capability expansions across sample preparation, separations, analytical instrumentation, and data analysis.
Help determine, drive, and deliver improvements to provide projects with data for rapid design-make-test cycles.
Qualifications Basic Qualifications:
Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related discipline, with 2+ years of relevant postdoctoral/industry experience; or M.S. with 5+ years; or B.S. with 8+ years.
Strong understanding of DMPK principles and bioanalytical workflows; significant experience analyzing DMPK/related assays (in vitro, in vivo, toxicokinetic) using mass spectrometry.
Expertise in mass spectrometry-based analysis of small molecules in discovery settings.
Experience working in matrix teams to deliver complex studies by providing bioanalytical guidance into study protocols/designs and scheduling.
Experience in implementing new instrumentation, technology, and workflows to solve challenging analytical problems.
Preferred Qualifications:
Well-developed skillset in using and troubleshooting Sciex mass spectrometers.
Experience working within discovery and GLP bioanalysis settings; track record of applying study-appropriate rigor to deliver data on time.
Previous bioanalysis of oligonucleotide therapeutics (siRNA, ASOs, or related modalities).
Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.
Why GSK? GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale. We’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture is built on being ambitious for patients, accountable for impact and doing the right thing.
If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).
Employment details
Seniority level: Not Applicable
Employment type: Full-time
Job function: Research, Analyst, and Information Technology
Industries: Pharmaceutical Manufacturing
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information, military service or any basis prohibited under federal, state or local law.
Important notice to Employment businesses/ Agencies: GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK.
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Join to apply for the
Principal Scientist, Discovery DMPK Bioanalytical
role at
GSK . Are you looking to apply your mass spectrometry skills to solve challenging bioanalytical problems and help drive discovery programs forward, helping patients across the globe? As a Discovery DMPK bioanalyst, you will be part of a team responsible for the analysis of molecules spanning GSK’s portfolio. Using state of the art equipment, we work with compounds at stages from early discovery to development in a fast-paced discovery laboratory environment. In this role you will have opportunities to utilize, challenge, and expand your bioanalytical skill sets for small molecules, oligonucleotides, biologics, and other emerging modalities.
Responsibilities
Within the Discovery DMPK group, utilize lab-bench technical knowledge and apply experience in LC-MS approaches to support GSK’s portfolio deliverables.
Focus on the bioanalytical support of DMPK assays, exploratory biology experiments (e.g., PK-PD), and non-GLP toxicokinetic studies across modalities.
Gain broad experience while also taking deep scientific dives to support challenging analyses; contribute to capability expansions across sample preparation, separations, analytical instrumentation, and data analysis.
Help determine, drive, and deliver improvements to provide projects with data for rapid design-make-test cycles.
Qualifications Basic Qualifications:
Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related discipline, with 2+ years of relevant postdoctoral/industry experience; or M.S. with 5+ years; or B.S. with 8+ years.
Strong understanding of DMPK principles and bioanalytical workflows; significant experience analyzing DMPK/related assays (in vitro, in vivo, toxicokinetic) using mass spectrometry.
Expertise in mass spectrometry-based analysis of small molecules in discovery settings.
Experience working in matrix teams to deliver complex studies by providing bioanalytical guidance into study protocols/designs and scheduling.
Experience in implementing new instrumentation, technology, and workflows to solve challenging analytical problems.
Preferred Qualifications:
Well-developed skillset in using and troubleshooting Sciex mass spectrometers.
Experience working within discovery and GLP bioanalysis settings; track record of applying study-appropriate rigor to deliver data on time.
Previous bioanalysis of oligonucleotide therapeutics (siRNA, ASOs, or related modalities).
Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.
Why GSK? GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale. We’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture is built on being ambitious for patients, accountable for impact and doing the right thing.
If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).
Employment details
Seniority level: Not Applicable
Employment type: Full-time
Job function: Research, Analyst, and Information Technology
Industries: Pharmaceutical Manufacturing
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information, military service or any basis prohibited under federal, state or local law.
Important notice to Employment businesses/ Agencies: GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK.
#J-18808-Ljbffr