Septerna, Inc.
Staff Scientist, Molecular Pharmacology (industry experience required)
Septerna, Inc., South San Francisco, California, us, 94083
Overview
Septerna is a biotechnology company based in South San Francisco, CA focused on GPCR-targeted drug discovery. The company uses its Native Complex Platform to recapitulate GPCRs with native structure, function, and dynamics to enable modern structural and screening technologies for industrial-scale drug discovery. Septerna is pursuing an emerging pipeline of GPCR-targeted small molecule programs with potential to address previously undruggable GPCRs. We are expanding our multidisciplinary team to develop revolutionary medicines for patients with unmet needs. Septerna values diversity of thought, expertise, and background and promotes collaboration, learning, and teamwork to accomplish our mission. This role will contribute to moving therapies through preclinical research and position them for clinic readiness. The successful candidate will bring their passion, talents, and expertise to a dynamic team focused on discovering disease-modifying therapeutics in a fast-paced environment. Position
Staff Scientist, Molecular Pharmacology (industry experience required) Responsibilities
Design, develop, and execute GPCR assays with a focus on assay fitness and robustness for large-scale small molecule high-throughput screening (HTS) applications Collaborate with Medicinal Chemistry, Protein Biology, and Disease Biology teams; manage external CRO partners Identify and establish key post-screen cellular, biochemical, and biophysical assays to support hit-to-lead through candidate selection Serve as the pharmacology point of contact for GPCR mechanism-of-action studies, including functional binding constants, quantification of agonist efficacy, and use of radiometric assays Provide deep technical expertise in cellular and molecular biology, including bespoke assay development and application for small molecule characterization; support for structure-activity relationship (SAR) campaigns is preferred Apply hands-on experience in genetic engineering, viral tools, and diverse readouts (second messenger, nucleic acid, and protein-based) used in assay readouts Utilize data analysis tools (e.g., GraphPad Prism, CD, Vortex/Dotmatix) to analyze dose–response, kinetic, and mechanism-of-action data to support hit triage and lead optimization Operate across all levels of the small molecule drug discovery funnel from Hit-ID to candidate selection Qualifications
Ph.D. in a relevant field with at least 5 years of industry experience in small molecule drug discovery. Familiarity with automation and liquid handling platforms used in HTS; direct management experience is preferred. Requirements
Design, develop, and execute GPCR assays with a focus on assay fitness and robustness for large-scale small molecule HTS Manage external CROs to advance discovery programs Identify and establish key post-screen cellular, biochemical, and biophysical assays to support hit-to-lead through candidate selection Pharmacology point of contact for GPCR mechanism-of-action studies including functional binding constants, agonist efficacy quantification, and radiometric assays Deep technical expertise in cellular and molecular biology with bespoke assay development for small molecule characterization; SAR campaign support is preferred Hands-on experience in genetic engineering, viral tools, and diverse assay readouts (second messenger, nucleic acid, and protein-based) Proficiency with data analysis tools such as GraphPad Prism and related software Experience with dose–response, kinetic, and mechanism-of-action data interpretation to support hit triage and lead optimization Experience across all stages of small molecule drug discovery from Hit-ID to candidate selection The anticipated salary range for candidates in South San Francisco, CA is $135,000 - $165,000. Compensation includes benefits, stock options, and an annual target bonus for full-time positions. We are an Equal Opportunity employer
and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
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Septerna is a biotechnology company based in South San Francisco, CA focused on GPCR-targeted drug discovery. The company uses its Native Complex Platform to recapitulate GPCRs with native structure, function, and dynamics to enable modern structural and screening technologies for industrial-scale drug discovery. Septerna is pursuing an emerging pipeline of GPCR-targeted small molecule programs with potential to address previously undruggable GPCRs. We are expanding our multidisciplinary team to develop revolutionary medicines for patients with unmet needs. Septerna values diversity of thought, expertise, and background and promotes collaboration, learning, and teamwork to accomplish our mission. This role will contribute to moving therapies through preclinical research and position them for clinic readiness. The successful candidate will bring their passion, talents, and expertise to a dynamic team focused on discovering disease-modifying therapeutics in a fast-paced environment. Position
Staff Scientist, Molecular Pharmacology (industry experience required) Responsibilities
Design, develop, and execute GPCR assays with a focus on assay fitness and robustness for large-scale small molecule high-throughput screening (HTS) applications Collaborate with Medicinal Chemistry, Protein Biology, and Disease Biology teams; manage external CRO partners Identify and establish key post-screen cellular, biochemical, and biophysical assays to support hit-to-lead through candidate selection Serve as the pharmacology point of contact for GPCR mechanism-of-action studies, including functional binding constants, quantification of agonist efficacy, and use of radiometric assays Provide deep technical expertise in cellular and molecular biology, including bespoke assay development and application for small molecule characterization; support for structure-activity relationship (SAR) campaigns is preferred Apply hands-on experience in genetic engineering, viral tools, and diverse readouts (second messenger, nucleic acid, and protein-based) used in assay readouts Utilize data analysis tools (e.g., GraphPad Prism, CD, Vortex/Dotmatix) to analyze dose–response, kinetic, and mechanism-of-action data to support hit triage and lead optimization Operate across all levels of the small molecule drug discovery funnel from Hit-ID to candidate selection Qualifications
Ph.D. in a relevant field with at least 5 years of industry experience in small molecule drug discovery. Familiarity with automation and liquid handling platforms used in HTS; direct management experience is preferred. Requirements
Design, develop, and execute GPCR assays with a focus on assay fitness and robustness for large-scale small molecule HTS Manage external CROs to advance discovery programs Identify and establish key post-screen cellular, biochemical, and biophysical assays to support hit-to-lead through candidate selection Pharmacology point of contact for GPCR mechanism-of-action studies including functional binding constants, agonist efficacy quantification, and radiometric assays Deep technical expertise in cellular and molecular biology with bespoke assay development for small molecule characterization; SAR campaign support is preferred Hands-on experience in genetic engineering, viral tools, and diverse assay readouts (second messenger, nucleic acid, and protein-based) Proficiency with data analysis tools such as GraphPad Prism and related software Experience with dose–response, kinetic, and mechanism-of-action data interpretation to support hit triage and lead optimization Experience across all stages of small molecule drug discovery from Hit-ID to candidate selection The anticipated salary range for candidates in South San Francisco, CA is $135,000 - $165,000. Compensation includes benefits, stock options, and an annual target bonus for full-time positions. We are an Equal Opportunity employer
and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
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