BioSpace
Scientist II/Senior Scientist I, Protein Analytical Characterization
BioSpace, Worcester, Massachusetts, us, 01609
Overview
Scientist II/Senior Scientist I, Protein Analytical Characterization Join to apply for the Scientist II/Senior Scientist I, Protein Analytical Characterization role at BioSpace Responsibilities
Independently develop and execute mass spectrometry workflows for comprehensive characterization of biologics and biotherapeutics (including intact, reduced, subunit, and peptide mapping). Develop, optimize, validate, and execute innovative analytical methods to characterize complex proteins/glycoproteins, antigens, and novel protein-based therapeutics. Ensure optimal functioning, calibration, and maintenance of laboratory equipment; proactively troubleshoot and resolve technical or experimental issues to minimize operational downtime. Resolve key project challenges and obstacles by leveraging available analytical tools, literature, and technical expertise, and proactively proposing solutions. Demonstrate scientific initiative and creativity in developing novel workflows and strategies for biologics characterization and screening—including non-traditional modalities (e.g., multi-specifics, alternative scaffolds, and fusion proteins) to support BGM and TA projects. Collaborate with external partners, CROs, or vendors as appropriate to advance project goals. Analyze, document, and report data concisely, formulate conclusions, and design follow-on experiments based on multidisciplinary data. Provide direct mentorship and guidance to junior scientists and team members, fostering their scientific development and growth. Communicate project progress, data analyses, and technical recommendations to cross-functional teams and senior management in a clear and timely manner. Present original research and findings internally and at external scientific conferences; contribute to scientific papers, patents, and technical reports as author or co-author. Qualifications
Scientist II: BS or equivalent education with typically 7 or more years of experience or MS or equivalent education with typically 5 or more years of experience. Sr. Scientist I: Bachelor’s Degree or equivalent education with typically 10 years of experience; Master’s Degree or equivalent education with typically 8 years of experience; PhD with no experience required. Extensive hands-on experience with commercial mass spectrometry platforms (e.g., Orbitrap, Q-ToF), advanced MS workflows for protein characterization, and use of MS data analysis software for both routine and complex sample sets. Direct, hands-on experience with biologics, monoclonal antibodies, and/or protein therapeutics, including characterization and analytical techniques. Demonstrated experience operating laboratory automation systems (e.g., Andrew+, Assaymap Bravo) for automated, high-throughput sample processing and preparation. Proficient in a range of analytical techniques, including chromatography (e.g., HPLC, UPLC) and capillary electrophoresis, with ability to troubleshoot and optimize these methods as needed. Working knowledge of biophysical and structural biology methods, such as DLS, DSF, HDX-MS, X-ray crystallography, or NMR spectroscopy (preferred). Familiarity or experience with coding/programming (e.g., Python, R, or relevant scripting languages) and in developing automated data workflows or solutions (preferred but not required). Demonstrated strong theoretical and practical foundation in the relevant scientific discipline, with proven ability to rapidly learn, master, and apply innovative technologies. Exceptional organizational skills and the ability to manage multiple concurrent projects and tasks efficiently within established timelines. Team-oriented and collaborative mindset, with excellent verbal and written communication skills; able to thrive in a fast-paced, dynamic, and multidisciplinary environment. Key AbbVie Competencies
Builds strong relationships with peers and cross functionally with partners outside of the team to enable high performance. Learns fast, grasps the essence and can change course quickly when indicated. Raises the bar and is never satisfied with the status quo. Creates a learning environment, open to suggestions and experimentation for improvement. Embraces the ideas of others, nurtures innovation and manages innovation to reality. Additional Information
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future. We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees. This job is eligible to participate in our short-term incentive programs. This job is eligible to participate in our long-term incentive programs. AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. US & Puerto Rico only - to learn more, visithttps://www.abbvie.com/join-us/equal-employment-opportunity-employer.html US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html
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Scientist II/Senior Scientist I, Protein Analytical Characterization Join to apply for the Scientist II/Senior Scientist I, Protein Analytical Characterization role at BioSpace Responsibilities
Independently develop and execute mass spectrometry workflows for comprehensive characterization of biologics and biotherapeutics (including intact, reduced, subunit, and peptide mapping). Develop, optimize, validate, and execute innovative analytical methods to characterize complex proteins/glycoproteins, antigens, and novel protein-based therapeutics. Ensure optimal functioning, calibration, and maintenance of laboratory equipment; proactively troubleshoot and resolve technical or experimental issues to minimize operational downtime. Resolve key project challenges and obstacles by leveraging available analytical tools, literature, and technical expertise, and proactively proposing solutions. Demonstrate scientific initiative and creativity in developing novel workflows and strategies for biologics characterization and screening—including non-traditional modalities (e.g., multi-specifics, alternative scaffolds, and fusion proteins) to support BGM and TA projects. Collaborate with external partners, CROs, or vendors as appropriate to advance project goals. Analyze, document, and report data concisely, formulate conclusions, and design follow-on experiments based on multidisciplinary data. Provide direct mentorship and guidance to junior scientists and team members, fostering their scientific development and growth. Communicate project progress, data analyses, and technical recommendations to cross-functional teams and senior management in a clear and timely manner. Present original research and findings internally and at external scientific conferences; contribute to scientific papers, patents, and technical reports as author or co-author. Qualifications
Scientist II: BS or equivalent education with typically 7 or more years of experience or MS or equivalent education with typically 5 or more years of experience. Sr. Scientist I: Bachelor’s Degree or equivalent education with typically 10 years of experience; Master’s Degree or equivalent education with typically 8 years of experience; PhD with no experience required. Extensive hands-on experience with commercial mass spectrometry platforms (e.g., Orbitrap, Q-ToF), advanced MS workflows for protein characterization, and use of MS data analysis software for both routine and complex sample sets. Direct, hands-on experience with biologics, monoclonal antibodies, and/or protein therapeutics, including characterization and analytical techniques. Demonstrated experience operating laboratory automation systems (e.g., Andrew+, Assaymap Bravo) for automated, high-throughput sample processing and preparation. Proficient in a range of analytical techniques, including chromatography (e.g., HPLC, UPLC) and capillary electrophoresis, with ability to troubleshoot and optimize these methods as needed. Working knowledge of biophysical and structural biology methods, such as DLS, DSF, HDX-MS, X-ray crystallography, or NMR spectroscopy (preferred). Familiarity or experience with coding/programming (e.g., Python, R, or relevant scripting languages) and in developing automated data workflows or solutions (preferred but not required). Demonstrated strong theoretical and practical foundation in the relevant scientific discipline, with proven ability to rapidly learn, master, and apply innovative technologies. Exceptional organizational skills and the ability to manage multiple concurrent projects and tasks efficiently within established timelines. Team-oriented and collaborative mindset, with excellent verbal and written communication skills; able to thrive in a fast-paced, dynamic, and multidisciplinary environment. Key AbbVie Competencies
Builds strong relationships with peers and cross functionally with partners outside of the team to enable high performance. Learns fast, grasps the essence and can change course quickly when indicated. Raises the bar and is never satisfied with the status quo. Creates a learning environment, open to suggestions and experimentation for improvement. Embraces the ideas of others, nurtures innovation and manages innovation to reality. Additional Information
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future. We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees. This job is eligible to participate in our short-term incentive programs. This job is eligible to participate in our long-term incentive programs. AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. US & Puerto Rico only - to learn more, visithttps://www.abbvie.com/join-us/equal-employment-opportunity-employer.html US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html
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