PTC Therapeutics, Inc.
Associate Scientist II, Biology
PTC Therapeutics, Inc., Bridgewater, Massachusetts, us, 02324
Overview
Associate Scientist II, Biology at PTC Therapeutics, Inc. PTC Therapeutics is a global commercial biopharmaceutical company. For over 25 years our team has been deeply committed to a unified purpose: Extending life’s moments for children and adults living with a rare disease. We cultivate an inclusive culture where everyone feels valued, respected, and empowered. We welcome candidates from all backgrounds to join our team, fostering a strong sense of belonging. Visit our website to learn more about our company and culture. Site: www.ptcbio.com Job Description Summary
The Associate Scientist II, Biology is responsible for performing scientific experiments that contribute to research and drug discovery activities at PTC. This position assists in the conduct of early stage research, the goal of which is the identification of New Chemical Entities (NCEs), as well as the advancement of research programs from the identification of screening hits to advanced lead optimization. The incumbent is also responsible for communicating experimental results to his/her supervisor and the project team. The Associate Scientist II, Biology supports adherence to all regulatory requirements and company Standard Operating Procedures (SOPs) including as appropriate. Responsibilities
Under minimal supervision, executes experiments as directed by the supervisor and communicates results as part of multi-disciplinary team(s). May also design and conduct independent research experiments. Analyze data from experience and understanding of databases such as Prism, Excel, etc. Applies relevant scientific principles and techniques to research problems. Maintains detailed laboratory notebooks. Maintains broad knowledge of state-of-the-art principles and techniques and may contribute to the identification of new project areas or technologies. Presents findings internally and externally and contributes to the publication of the work of the project team in well-established and peer reviewed journals, subject to internal scientific and legal approval. May provide technical and scientific input to the project team or research leadership. Contributes to the development of patent applications as appropriate. Complies with all safety requirements. Contributes to general lab operations such as equipment maintenance, identification of capital equipment needs, maintenance of clean and uncluttered work areas, inventory maintenance, and ordering of supplies as needed. Provides support for high throughput screening including the design of primary assays to identify additional hits and new chemical scaffolds. Supports lead optimization by screening compounds and/or supporting SAR studies involving the characterization of biological activity of compounds in various assays; profiles selected compounds in additional cells/assays. Provides support for in vivo studies as required and assists in developing biologically relevant alternatives to preclinical animal models. Conducts mechanism of drug activity studies. Qualifications
Mammalian tissue culture experience, nucleic acid transfection, stable clone generation, cryopreservation, cytotoxicity and cell-based reporter assays. Experience with RNA including purification and quantification of gene expression (e.g., Endpoint PCR, qRT-PCR, ddPCR). Experience with standard cell and molecular biology techniques including molecular cloning, SDS-PAGE, western blot, ELISA/MSD. Hands-on experience in cell sorting techniques (FACS). Experience in handling human and mouse blood samples. Bachelor’s degree in a scientific discipline with a minimum of 5 years’ experience or Master’s degree with a minimum of 2 years relevant experience. Demonstrates high technical proficiency, scientific creativity, independent thought, and ability to collaborate with others on cross-functional teams in a fast-paced environment. Knowledge of scientific principles and literature; proficiency with Microsoft Office, GraphPad Prism. Effective verbal and written communication; analytical thinking and problem-solving; strong planning, organization, and time management skills. Immunoassay experience (moderate to high-throughput) for protein detection across platforms (western blotting, MSD, ELISA). Background in neuroscience and experience in assay development are preferred. Proficiency in flow cytometry is preferred. Travel up to 5%; office/laboratory-based position with on-site work Mon-Fri; flexible scheduling including occasional weekend work to maintain healthy cell cultures. Compensation and Benefits
Expected Base Salary Range: $81,000 - $100,000. The base salary offered will be contingent on assessment of candidate education level, background, and experience relative to the requirements of the position as well as internal equity. In addition to base salary, eligible employees may participate in short- and long-term incentives, and enroll in PTC’s medical, dental, vision, and retirement savings plans. EEO Statement
PTC Therapeutics is an equal opportunity employer. We welcome applications from all individuals, regardless of race, color, national origin, gender, age, physical characteristics, disability, religion, family status, pregnancy, sexual orientation, gender identity, gender expression, veteran status or any unlawful criterion under applicable law. We are committed to treating all applicants fairly and avoiding discrimination. Click here to return to the careers page
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Associate Scientist II, Biology at PTC Therapeutics, Inc. PTC Therapeutics is a global commercial biopharmaceutical company. For over 25 years our team has been deeply committed to a unified purpose: Extending life’s moments for children and adults living with a rare disease. We cultivate an inclusive culture where everyone feels valued, respected, and empowered. We welcome candidates from all backgrounds to join our team, fostering a strong sense of belonging. Visit our website to learn more about our company and culture. Site: www.ptcbio.com Job Description Summary
The Associate Scientist II, Biology is responsible for performing scientific experiments that contribute to research and drug discovery activities at PTC. This position assists in the conduct of early stage research, the goal of which is the identification of New Chemical Entities (NCEs), as well as the advancement of research programs from the identification of screening hits to advanced lead optimization. The incumbent is also responsible for communicating experimental results to his/her supervisor and the project team. The Associate Scientist II, Biology supports adherence to all regulatory requirements and company Standard Operating Procedures (SOPs) including as appropriate. Responsibilities
Under minimal supervision, executes experiments as directed by the supervisor and communicates results as part of multi-disciplinary team(s). May also design and conduct independent research experiments. Analyze data from experience and understanding of databases such as Prism, Excel, etc. Applies relevant scientific principles and techniques to research problems. Maintains detailed laboratory notebooks. Maintains broad knowledge of state-of-the-art principles and techniques and may contribute to the identification of new project areas or technologies. Presents findings internally and externally and contributes to the publication of the work of the project team in well-established and peer reviewed journals, subject to internal scientific and legal approval. May provide technical and scientific input to the project team or research leadership. Contributes to the development of patent applications as appropriate. Complies with all safety requirements. Contributes to general lab operations such as equipment maintenance, identification of capital equipment needs, maintenance of clean and uncluttered work areas, inventory maintenance, and ordering of supplies as needed. Provides support for high throughput screening including the design of primary assays to identify additional hits and new chemical scaffolds. Supports lead optimization by screening compounds and/or supporting SAR studies involving the characterization of biological activity of compounds in various assays; profiles selected compounds in additional cells/assays. Provides support for in vivo studies as required and assists in developing biologically relevant alternatives to preclinical animal models. Conducts mechanism of drug activity studies. Qualifications
Mammalian tissue culture experience, nucleic acid transfection, stable clone generation, cryopreservation, cytotoxicity and cell-based reporter assays. Experience with RNA including purification and quantification of gene expression (e.g., Endpoint PCR, qRT-PCR, ddPCR). Experience with standard cell and molecular biology techniques including molecular cloning, SDS-PAGE, western blot, ELISA/MSD. Hands-on experience in cell sorting techniques (FACS). Experience in handling human and mouse blood samples. Bachelor’s degree in a scientific discipline with a minimum of 5 years’ experience or Master’s degree with a minimum of 2 years relevant experience. Demonstrates high technical proficiency, scientific creativity, independent thought, and ability to collaborate with others on cross-functional teams in a fast-paced environment. Knowledge of scientific principles and literature; proficiency with Microsoft Office, GraphPad Prism. Effective verbal and written communication; analytical thinking and problem-solving; strong planning, organization, and time management skills. Immunoassay experience (moderate to high-throughput) for protein detection across platforms (western blotting, MSD, ELISA). Background in neuroscience and experience in assay development are preferred. Proficiency in flow cytometry is preferred. Travel up to 5%; office/laboratory-based position with on-site work Mon-Fri; flexible scheduling including occasional weekend work to maintain healthy cell cultures. Compensation and Benefits
Expected Base Salary Range: $81,000 - $100,000. The base salary offered will be contingent on assessment of candidate education level, background, and experience relative to the requirements of the position as well as internal equity. In addition to base salary, eligible employees may participate in short- and long-term incentives, and enroll in PTC’s medical, dental, vision, and retirement savings plans. EEO Statement
PTC Therapeutics is an equal opportunity employer. We welcome applications from all individuals, regardless of race, color, national origin, gender, age, physical characteristics, disability, religion, family status, pregnancy, sexual orientation, gender identity, gender expression, veteran status or any unlawful criterion under applicable law. We are committed to treating all applicants fairly and avoiding discrimination. Click here to return to the careers page
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