Northwestern University
Postdoctoral Scholar in Epigenetics and Metabolism
Northwestern University, Chicago, Illinois, United States, 60290
Overview
A fully funded postdoctoral position is available in the collaborative laboratories of Dr. Shannon Lauberth and Dr. Issam Ben-Sahra to investigate the interface between epigenetic regulation and cellular metabolism in cancer. This position is part of an interdisciplinary effort to uncover how transcriptional regulators influence nucleotide metabolism and how metabolic pathways, in turn, shape gene expression programs. The successful candidate will use state-of-the-art approaches including CRISPR screening, ChIP-seq, RNA-seq, metabolomics, and proteomics to uncover new molecular mechanisms that link chromatin regulation to metabolic control. The fellow will be trained in a dynamic and collaborative environment with access to cutting-edge facilities and mentorship across molecular biology, epigenetics, and cancer metabolism. Occasional weekends and evenings and some travel may be required.
Responsibilities
The postdoc fellow will lead experimental studies to uncover how key transcriptional regulators modulate nucleotide/cellular metabolism. The fellow will employ cutting-edge techniques including CRISPR screens, RNA-seq, and metabolomic profiling to investigate transcriptional and metabolic alterations in response to epigenetic disruptions.
The postdoc fellow will analyze complex multi-omics datasets to identify critical regulatory nodes between nucleotide synthesis and transcriptional regulation. Findings will be essential in shaping future research directions and experimental designs.
The postdoc fellow will work closely with Drs. Issam Ben-Sahra and Shannon Lauberth, as well as other interdisciplinary collaborators, to integrate expertise from different fields and lead team-based projects.
The postdoc fellow will contribute to the writing of research papers and grant proposals based on findings, enhancing the scientific output and securing funding for continued research in epigenetics and metabolism.
The postdoc fellow will translate fundamental research findings into potential clinical applications by identifying metabolic vulnerabilities in cancer cells, contributing to the department’s goal of developing innovative cancer treatments.
Minimum Qualifications
Ph.D. in Biochemistry or related fields
Minimum Competencies
PCR, Western blots, tissue culture techniques, ChIP, RNA-seq, CRISPR/Cas9-based perturbations, and metabolomics to identify regulatory nodes within the transcription–metabolism axis.
Preferred Qualifications
Ph.D. in biochemistry and molecular biology
Preferred Competencies
PCR, Western blots, tissue culture techniques, ChIP, RNA-seq, metabolomics, Seahorse assay
Equal Opportunity Northwestern University is an Equal Opportunity Employer and does not discriminate on the basis of protected characteristics, including disability and veteran status. Job applicants who wish to request an accommodation in the application or hiring process should contact the Office of Civil Rights and Title IX Compliance. View information on the accommodations process.
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Responsibilities
The postdoc fellow will lead experimental studies to uncover how key transcriptional regulators modulate nucleotide/cellular metabolism. The fellow will employ cutting-edge techniques including CRISPR screens, RNA-seq, and metabolomic profiling to investigate transcriptional and metabolic alterations in response to epigenetic disruptions.
The postdoc fellow will analyze complex multi-omics datasets to identify critical regulatory nodes between nucleotide synthesis and transcriptional regulation. Findings will be essential in shaping future research directions and experimental designs.
The postdoc fellow will work closely with Drs. Issam Ben-Sahra and Shannon Lauberth, as well as other interdisciplinary collaborators, to integrate expertise from different fields and lead team-based projects.
The postdoc fellow will contribute to the writing of research papers and grant proposals based on findings, enhancing the scientific output and securing funding for continued research in epigenetics and metabolism.
The postdoc fellow will translate fundamental research findings into potential clinical applications by identifying metabolic vulnerabilities in cancer cells, contributing to the department’s goal of developing innovative cancer treatments.
Minimum Qualifications
Ph.D. in Biochemistry or related fields
Minimum Competencies
PCR, Western blots, tissue culture techniques, ChIP, RNA-seq, CRISPR/Cas9-based perturbations, and metabolomics to identify regulatory nodes within the transcription–metabolism axis.
Preferred Qualifications
Ph.D. in biochemistry and molecular biology
Preferred Competencies
PCR, Western blots, tissue culture techniques, ChIP, RNA-seq, metabolomics, Seahorse assay
Equal Opportunity Northwestern University is an Equal Opportunity Employer and does not discriminate on the basis of protected characteristics, including disability and veteran status. Job applicants who wish to request an accommodation in the application or hiring process should contact the Office of Civil Rights and Title IX Compliance. View information on the accommodations process.
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