Johnson & Johnson Innovative Medicine
Senior Scientist, Computer-Aided Drug Design (CADD) - In Silico Discovery
Johnson & Johnson Innovative Medicine, Spring House, Pennsylvania, United States, 19477
Overview
Johnson & Johnson Innovative Medicine (JJIM) is recruiting for a
Senior Scientist, Computer-Aided Drug Design (CADD) - In Silico Discovery
to join our Therapeutics Discovery team located in either San Diego, CA (La Jolla area) or Spring House, PA (Philadelphia area). The Therapeutics Discovery organization within JJIM is building scientific expertise in modeling, screening, pharmacology and chemistry to partner with therapeutic area scientists to develop groundbreaking medicines in Immunology, Neuroscience and Oncology. The In Silico Discovery (ISD) group is seeking to advance exciting and novel areas of computational drug design.
Key Responsibilities
Design therapeutic molecules and calculate their properties using state-of-the-art methodologies integrating chemical, biological and structural data, cheminformatics, and artificial intelligence/machine learning techniques Serve as a scientific expert and contribute in multi-disciplinary discovery project teams that include synthetic chemists, structural biologists, and other discovery scientists, by providing key computational expertise to advance drug discovery projects Collaborate within Janssen and with external academic and industrial partners to develop new computational technologies to address key questions in drug discovery Publish results in peer reviewed journals and present at scientific meetings Mentor junior scientists and/or interns fostering their development as expert computational drug hunters Contribute to efforts to evaluate and assess novel protein targets of interest for their ligandability and tractability against various modalities (small molecule, degraders, peptide, glues, etc.)
Qualifications
A PhD in computational chemistry, organic chemistry or a related field, with at least 1-5 years of experience applying computational modeling in a pharmaceutical industry drug design setting Excellent written and verbal communication skills, and a publication record Experience with multiple therapeutic modalities (e.g. small molecules, biologics, peptides, targeted protein degraders) is preferred Experience with cross-functional environments, mentoring scientists, influencing decisions and resolving conflicts is strongly preferred Familiarity with at least one standard computational drug discovery package (e.g. Maestro/Schrodinger, MOE/Chemical Computing Group, OpenEye) is required Experience scripting computational workflows in Pipeline Pilot, KNIME, Python or Jupyter notebooks is preferred
This is a Hybrid role available in Spring House, PA, or San Diego, CA within the US (no fully remote option). Travel up to approximately 10% may be required, domestic and international.
Compensation & Benefits
Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. The anticipated base pay range for this position is $105,000 to $169,050. The Company maintains competitive compensation programs. Bonuses, benefits and retirement plans are described in the job posting. We are committed to inclusive recruiting and an interview process that accommodates applicants with disabilities. If you require an accommodation, please contact us via the Careers site. Travel up to 10% may be required. This posting is for candidates hired in the United States.
Locations
San Diego, California, United States of America; Spring House, Pennsylvania, United States of America
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Johnson & Johnson Innovative Medicine (JJIM) is recruiting for a
Senior Scientist, Computer-Aided Drug Design (CADD) - In Silico Discovery
to join our Therapeutics Discovery team located in either San Diego, CA (La Jolla area) or Spring House, PA (Philadelphia area). The Therapeutics Discovery organization within JJIM is building scientific expertise in modeling, screening, pharmacology and chemistry to partner with therapeutic area scientists to develop groundbreaking medicines in Immunology, Neuroscience and Oncology. The In Silico Discovery (ISD) group is seeking to advance exciting and novel areas of computational drug design.
Key Responsibilities
Design therapeutic molecules and calculate their properties using state-of-the-art methodologies integrating chemical, biological and structural data, cheminformatics, and artificial intelligence/machine learning techniques Serve as a scientific expert and contribute in multi-disciplinary discovery project teams that include synthetic chemists, structural biologists, and other discovery scientists, by providing key computational expertise to advance drug discovery projects Collaborate within Janssen and with external academic and industrial partners to develop new computational technologies to address key questions in drug discovery Publish results in peer reviewed journals and present at scientific meetings Mentor junior scientists and/or interns fostering their development as expert computational drug hunters Contribute to efforts to evaluate and assess novel protein targets of interest for their ligandability and tractability against various modalities (small molecule, degraders, peptide, glues, etc.)
Qualifications
A PhD in computational chemistry, organic chemistry or a related field, with at least 1-5 years of experience applying computational modeling in a pharmaceutical industry drug design setting Excellent written and verbal communication skills, and a publication record Experience with multiple therapeutic modalities (e.g. small molecules, biologics, peptides, targeted protein degraders) is preferred Experience with cross-functional environments, mentoring scientists, influencing decisions and resolving conflicts is strongly preferred Familiarity with at least one standard computational drug discovery package (e.g. Maestro/Schrodinger, MOE/Chemical Computing Group, OpenEye) is required Experience scripting computational workflows in Pipeline Pilot, KNIME, Python or Jupyter notebooks is preferred
This is a Hybrid role available in Spring House, PA, or San Diego, CA within the US (no fully remote option). Travel up to approximately 10% may be required, domestic and international.
Compensation & Benefits
Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. The anticipated base pay range for this position is $105,000 to $169,050. The Company maintains competitive compensation programs. Bonuses, benefits and retirement plans are described in the job posting. We are committed to inclusive recruiting and an interview process that accommodates applicants with disabilities. If you require an accommodation, please contact us via the Careers site. Travel up to 10% may be required. This posting is for candidates hired in the United States.
Locations
San Diego, California, United States of America; Spring House, Pennsylvania, United States of America
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