Postdoctoral Scientist - Marine Biomedical Discovery

Job Description: Salary: Gloucester Marine Genomics Institute (GMGI) is an independent research institute addressing critical challenges facing our oceans, human health, and the environment through innovative scientific research and education. GMGI is looking for a Postdoctoral Scientist to join our team studying the biology of exceptionally long-lived marine animals. Our goal is to translate evolutionary insights from these exceptional animals into interventions that promote human healthspan and combat related diseases, using zebrafish as a development platform. This position will mine the genomes of long- and short-lived fishes and clams to identify evolutionary mechanisms that set lifespan. These mechanisms will then be genetically modeled in zebrafish to extend healthy aging. The project will use extensive computational methods, modern genetic tools, and develop new assays to modulate and test the molecular mechanisms of aging. The ideal candidate will have strong leadership skills, excellent communication skills, and the ability to work with a multi-disciplinary team of collaborators. This is an extraordinary opportunity for a dynamic and motivated scientist to learn a powerful genetic model and advance aging research in an entrepreneurial and exciting work environment. Responsibilities:

Lead research projects in comparative genomics of exceptionally short- and long-lived species. Generate comparative resources through sequencing, assembly, and annotation of diverse genomes using modern bioinformatic tools. Use existing phylogenetic analytical tools and develop novel ones when necessary to glean evolutionary insights into the regulation of lifespan from diverse omics data. Curate diverse biological datasets to form the basis of meta-analyses to identify shared signals underlying the evolution of lifespan. Develop evolutionary signals underlying lifespan variation into genetic interventions to evaluate their effect on aging and healthspan in zebrafish. Develop and apply assays to measure and quantify biological aging in zebrafish, including methylation clocks, histology, and compound neuro-muscular functionality. Contribute to the maintenance of transgenic zebrafish lines, including microinjection, mutant screening, and genotyping. Analyze experimental data with high proficiency using appropriate bioinformatic and statistical approaches. Lead the publication of results in peer-reviewed scientific journals and present research findings at scientific conferences. Contribute to grant proposals, institutional fund-raising activities, and community outreach activities. Mentor interns and research staff as needed. Qualifications:

PhD in molecular/cell biology, bioinformatics, or a related field, with particular emphasis on phylogenetics. Experience with standard molecular biology techniques such as DNA/RNA isolation, PCR/qPCR, molecular cloning, and CRISPR gene editing. Experience generating and analyzing omics data with particular expertise in analyzing non-model species. Strong computational skills and experience with standard bioinformatic and statistic software packages. Proficient with the Linux environment and knowledge in command line interface, writing shell scripts, and applying scripts commonly used for biological data analysis (i.e., Python, R). Strong publication record representing innovative, high-quality research. Experience working with aquatic models is desirable. Experience with methylation clocks is desirable. Excellent communication and teamwork skills. Demonstrated record of leadership, integrity, and flexibility. Enthusiasm and commitment to GMGI's mission for science and education. This position will report to the Research Scientist. GMGI offers a benefit package that includes health and dental insurance, medical and dependent flex spending accounts, long-term life insurance, paid time off, 403(b) retirement plan, and 12 paid holidays. Applicants must be authorized to work in the US. GMGI is an equal opportunity employer, and all aspects of employment are based on merit, competence, performance, and business need. We are committed to supporting diversity in our workforce and classrooms. Please visit our website for more information: www.gmgi.org

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