Oklahoma Medical Research Foundation
Postdoctoral Scientist - Donczew Lab
Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States, 73116
Overview
Postdoctoral Scientist - Donczew Lab, Department: Cell Cycle & Cancer Biology, Location: Oklahoma City, OK. The Donczew Lab in the Cell Cycle and Cancer Biology Research Program is seeking a Postdoctoral Scientist to investigate the mechanisms of transcription and DNA replication, and their crosstalk, using yeast as a model system. Potential research directions include applying long-read sequencing to examine genome-wide replication programs, exploring how replication factors coordinate transcription and DNA replication, defining the role of transcription regulators (e.g., BET proteins) in replication initiation, and uncovering mechanisms of transcription inhibition by the S-phase checkpoint. The research combines molecular genetics, genomics (short- and long-read sequencing), and computational biology. The specific project will be defined collaboratively with the selected candidate, emphasizing creativity, initiative, and demonstrated interest in gene regulation and/or DNA replication. The position is fully funded, and fellows will be encouraged and supported in pursuing independent postdoctoral funding opportunities.
Responsibilities
Design and conduct experiments to investigate transcription, DNA replication, and their interplay. Develop and apply genomic approaches, including long-read sequencing, to study replication programs under various perturbations. Explore the role of replication factors and transcription regulators in genome stability and replication initiation. Employ molecular genetics, genomics, and computational biology to address key questions. Collaborate with the PI to define and refine the research project scope. Prepare manuscripts for publication and present research at seminars, conferences, and symposia. Contribute to a collaborative and innovative laboratory environment. Seek external fellowship opportunities with mentorship and institutional support.
Minimum Qualifications
Ph.D. in a biological science or relevant area, M.D., or equivalent. Knowledge of principles and practices of scientific theory and research. Skill in formulating and testing hypotheses; capable of conducting scientific experiments. Strong ability to organize, interpret, and present data. Experience in writing technical, scientific papers and grants; effective communication skills, both oral and written; strong collaboration skills. Experience in providing leadership through mentoring and guiding students and junior scientists.
Preferred Qualifications
Experience in studies of transcription and/or DNA replication. Familiarity with yeast and/or mammalian cell line model systems. Experience in molecular biology, biochemistry, next-generation sequencing data analysis and experimentation (e.g., ChIP-seq, RNA-seq, long-read sequencing, etc.). Demonstrated proficiency in preparing manuscripts for publication.
About Oklahoma Medical Research Foundation (OMRF)
Founded in 1946, the Oklahoma Medical Research Foundation (OMRF) is among the nation's oldest independent, nonprofit biomedical research institutes. OMRF conducts research across critical areas including Alzheimer’s disease, cancer, lupus, multiple sclerosis, and cardiovascular disease. OMRF emphasizes cross-disciplinary medical research and ranks among the nation"s leaders in patents per scientist. Located in Oklahoma City, OMRF offers a dynamic community with a favorable work environment.
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Postdoctoral Scientist - Donczew Lab, Department: Cell Cycle & Cancer Biology, Location: Oklahoma City, OK. The Donczew Lab in the Cell Cycle and Cancer Biology Research Program is seeking a Postdoctoral Scientist to investigate the mechanisms of transcription and DNA replication, and their crosstalk, using yeast as a model system. Potential research directions include applying long-read sequencing to examine genome-wide replication programs, exploring how replication factors coordinate transcription and DNA replication, defining the role of transcription regulators (e.g., BET proteins) in replication initiation, and uncovering mechanisms of transcription inhibition by the S-phase checkpoint. The research combines molecular genetics, genomics (short- and long-read sequencing), and computational biology. The specific project will be defined collaboratively with the selected candidate, emphasizing creativity, initiative, and demonstrated interest in gene regulation and/or DNA replication. The position is fully funded, and fellows will be encouraged and supported in pursuing independent postdoctoral funding opportunities.
Responsibilities
Design and conduct experiments to investigate transcription, DNA replication, and their interplay. Develop and apply genomic approaches, including long-read sequencing, to study replication programs under various perturbations. Explore the role of replication factors and transcription regulators in genome stability and replication initiation. Employ molecular genetics, genomics, and computational biology to address key questions. Collaborate with the PI to define and refine the research project scope. Prepare manuscripts for publication and present research at seminars, conferences, and symposia. Contribute to a collaborative and innovative laboratory environment. Seek external fellowship opportunities with mentorship and institutional support.
Minimum Qualifications
Ph.D. in a biological science or relevant area, M.D., or equivalent. Knowledge of principles and practices of scientific theory and research. Skill in formulating and testing hypotheses; capable of conducting scientific experiments. Strong ability to organize, interpret, and present data. Experience in writing technical, scientific papers and grants; effective communication skills, both oral and written; strong collaboration skills. Experience in providing leadership through mentoring and guiding students and junior scientists.
Preferred Qualifications
Experience in studies of transcription and/or DNA replication. Familiarity with yeast and/or mammalian cell line model systems. Experience in molecular biology, biochemistry, next-generation sequencing data analysis and experimentation (e.g., ChIP-seq, RNA-seq, long-read sequencing, etc.). Demonstrated proficiency in preparing manuscripts for publication.
About Oklahoma Medical Research Foundation (OMRF)
Founded in 1946, the Oklahoma Medical Research Foundation (OMRF) is among the nation's oldest independent, nonprofit biomedical research institutes. OMRF conducts research across critical areas including Alzheimer’s disease, cancer, lupus, multiple sclerosis, and cardiovascular disease. OMRF emphasizes cross-disciplinary medical research and ranks among the nation"s leaders in patents per scientist. Located in Oklahoma City, OMRF offers a dynamic community with a favorable work environment.
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