Protagonist Therapeutics
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Senior Scientist, DMPK
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Protagonist Therapeutics 5 days ago Be among the first 25 applicants Join to apply for the
Senior Scientist, DMPK
role at
Protagonist Therapeutics Get AI-powered advice on this job and more exclusive features. Protagonist Therapeutics provided pay range
This range is provided by Protagonist Therapeutics. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more. Base pay range
$150,000.00/yr - $175,000.00/yr Sr. Scientist, DMPK
We are seeking a Sr. Scientist in the Drug Metabolism and Pharmacokinetic (DMPK) department. The qualified candidate will be a critical member of the group and work closely with our established team performing and overseeing various in vitro metabolism assays, metabolite identification studies, and bioanalytical work to screen chemical entities for new drug candidates. This is an exceptional opportunity to work with a core discovery group within a successful biopharmaceutical company and bring drugs from ideas to the clinic.
Responsibilities include, but are not limited to:
Independently design, perform, and manage various in vitro metabolism studies to address specific DMPK questions in drug discovery Develop analytical methods using a mass spectrometer (LC-MS/MS) to separate and detect small molecules /peptides Prepare and deliver scientific presentations and reports to communicate research results within and outside the DMPK department Influence discovery decisions and contribute significantly to corporate goals and project milestones Maintain a command of relevant scientific literature, research method sections of DMPK publications and evaluate implications for internal projects Assume responsibility for maintaining laboratory equipment, facilitate their use by other scientists, and maintain clear, detailed, and up-to-date experimental records Conduct other duties as assigned
Position Requirements & Experience:
Master’s degree in Biological Sciences, Chemistry with at least 5-7 years of industry experience with hands-on, relevant DMPK lab experience (or Bachelor’s degree in Biological Sciences, Chemistry, or related field with at least 8-10 years) Experience performing, interpreting, and reporting metabolic stability, DDI, and metabolite ID studies in liver subcellular fractions, preparing and analyzing samples from biological matrices using a mass spectrometer (LC-MS/MS) as the primary analytical tool, and with sample preparation and bioanalysis of preclinical in vitro and in vivo ADME/PK studies Proficient in using and troubleshooting a LC-MS/MS (Sciex instrumentation is a plus) Experience performing NCA analysis using Phoenix WinNonlin for preclinical PK studies Demonstrated technical proficiency, scientific creativity, problem solving ability, and capable of independently planning and executing experiments Excellent interpersonal, verbal, and written communication skills are essential in this collaborative work environment Highly motivated and able to work in a fast-paced environment with a desire to learn and tackle new challenges
The base pay range for this position at commencement of employment is expected to be between $150K and $175K / year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience.
Protagonist Therapeutics is a discovery through late-stage development biopharmaceutical company. Two novel peptides, icotrokinra and rusfertide, derived from Protagonist's proprietary discovery platform are currently in advanced Phase 3 clinical development, with New Drug Application submissions to the FDA expected in 2025. Icotrokinra (JNJ-2113) is a first-in-class investigational targeted oral peptide that selectively blocks the Interleukin-23 receptor ("IL-23R") which is licensed to Janssen Biotech, Inc., a Johnson & Johnson company. Following icotrokinra's joint discovery by Protagonist and Johnson & Johnson scientists pursuant to the companies' IL-23R collaboration, Protagonist was primarily responsible for development of icotrokinra through Phase 1, with Johnson & Johnson assuming responsibility for development in Phase 2 and beyond. Rusfertide, a mimetic of the natural hormone hepcidin, is currently in Phase 3 development for the rare blood disorder polycythemia vera (PV). Rusfertide is being co-developed and will be co-commercialized with Takeda Pharmaceuticals pursuant to a worldwide collaboration and license agreement entered into in 2024 under which the Company remains primarily responsible for development through NDA filing. The Company also has a number of pre-clinical stage oral drug discovery programs addressing clinically and commercially validated targets, including the IL-17 oral peptide antagonist PN-881, an oral hepcidin program, and an oral obesity program. Seniority level
Seniority level Mid-Senior level Employment type
Employment type Full-time Job function
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Senior Scientist, DMPK
role at
Protagonist Therapeutics 5 days ago Be among the first 25 applicants Join to apply for the
Senior Scientist, DMPK
role at
Protagonist Therapeutics Get AI-powered advice on this job and more exclusive features. Protagonist Therapeutics provided pay range
This range is provided by Protagonist Therapeutics. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more. Base pay range
$150,000.00/yr - $175,000.00/yr Sr. Scientist, DMPK
We are seeking a Sr. Scientist in the Drug Metabolism and Pharmacokinetic (DMPK) department. The qualified candidate will be a critical member of the group and work closely with our established team performing and overseeing various in vitro metabolism assays, metabolite identification studies, and bioanalytical work to screen chemical entities for new drug candidates. This is an exceptional opportunity to work with a core discovery group within a successful biopharmaceutical company and bring drugs from ideas to the clinic.
Responsibilities include, but are not limited to:
Independently design, perform, and manage various in vitro metabolism studies to address specific DMPK questions in drug discovery Develop analytical methods using a mass spectrometer (LC-MS/MS) to separate and detect small molecules /peptides Prepare and deliver scientific presentations and reports to communicate research results within and outside the DMPK department Influence discovery decisions and contribute significantly to corporate goals and project milestones Maintain a command of relevant scientific literature, research method sections of DMPK publications and evaluate implications for internal projects Assume responsibility for maintaining laboratory equipment, facilitate their use by other scientists, and maintain clear, detailed, and up-to-date experimental records Conduct other duties as assigned
Position Requirements & Experience:
Master’s degree in Biological Sciences, Chemistry with at least 5-7 years of industry experience with hands-on, relevant DMPK lab experience (or Bachelor’s degree in Biological Sciences, Chemistry, or related field with at least 8-10 years) Experience performing, interpreting, and reporting metabolic stability, DDI, and metabolite ID studies in liver subcellular fractions, preparing and analyzing samples from biological matrices using a mass spectrometer (LC-MS/MS) as the primary analytical tool, and with sample preparation and bioanalysis of preclinical in vitro and in vivo ADME/PK studies Proficient in using and troubleshooting a LC-MS/MS (Sciex instrumentation is a plus) Experience performing NCA analysis using Phoenix WinNonlin for preclinical PK studies Demonstrated technical proficiency, scientific creativity, problem solving ability, and capable of independently planning and executing experiments Excellent interpersonal, verbal, and written communication skills are essential in this collaborative work environment Highly motivated and able to work in a fast-paced environment with a desire to learn and tackle new challenges
The base pay range for this position at commencement of employment is expected to be between $150K and $175K / year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience.
Protagonist Therapeutics is a discovery through late-stage development biopharmaceutical company. Two novel peptides, icotrokinra and rusfertide, derived from Protagonist's proprietary discovery platform are currently in advanced Phase 3 clinical development, with New Drug Application submissions to the FDA expected in 2025. Icotrokinra (JNJ-2113) is a first-in-class investigational targeted oral peptide that selectively blocks the Interleukin-23 receptor ("IL-23R") which is licensed to Janssen Biotech, Inc., a Johnson & Johnson company. Following icotrokinra's joint discovery by Protagonist and Johnson & Johnson scientists pursuant to the companies' IL-23R collaboration, Protagonist was primarily responsible for development of icotrokinra through Phase 1, with Johnson & Johnson assuming responsibility for development in Phase 2 and beyond. Rusfertide, a mimetic of the natural hormone hepcidin, is currently in Phase 3 development for the rare blood disorder polycythemia vera (PV). Rusfertide is being co-developed and will be co-commercialized with Takeda Pharmaceuticals pursuant to a worldwide collaboration and license agreement entered into in 2024 under which the Company remains primarily responsible for development through NDA filing. The Company also has a number of pre-clinical stage oral drug discovery programs addressing clinically and commercially validated targets, including the IL-17 oral peptide antagonist PN-881, an oral hepcidin program, and an oral obesity program. Seniority level
Seniority level Mid-Senior level Employment type
Employment type Full-time Job function
Job function Research, Analyst, and Information Technology Industries Biotechnology Referrals increase your chances of interviewing at Protagonist Therapeutics by 2x Get notified about new Senior Scientist jobs in
Newark, CA . Newark, CA $150,000.00-$175,000.00 5 days ago Fremont, CA $110,000.00-$115,000.00 1 week ago Menlo Park, CA $100,000.00-$150,000.00 2 weeks ago Principal/Senior Scientist, Analytical Science
Scientist/Senior Scientist, Analytical Chemistry
San Mateo County, CA $75.00-$85.00 1 week ago Senior Scientist I, Biologics Drug Substance Development (Cell Culture Development)
South San Francisco, CA $94,000.00-$178,500.00 2 days ago Senior Staff Scientist, Medicinal Chemistry (industry experience required)
South San Francisco, CA $170,000.00-$180,000.00 2 weeks ago Research Scientist - Computational Chemistry
Oakland, CA $150,000.00-$200,000.00 1 month ago Assoc Scientist R&D, RNA Assay Development
Scientist 1/2/Senior Scientist, Analytical Development
Brisbane, CA $140,250.00-$216,500.00 1 day ago Senior Scientist II, Analytical Development
Senior Scientist (Analytical Development CMC)
South San Francisco, CA $138,000.00-$174,000.00 2 weeks ago Polymer Formulation & Characterization - Scientist I-III/Senior/Lead
Alameda, CA $110,000.00-$180,000.00 1 week ago Hayward, CA $85,000.00-$100,000.00 2 weeks ago San Francisco Bay Area $135,000.00-$180,000.00 20 hours ago Principal II Scientist, Applied Chemistry
Senior Scientist I, Analytical Development
Santa Clara, CA $86,700.00-$173,300.00 3 days ago Senior Scientist -- Pre-Pivotal Biologics, Analytical Operations
San Francisco Bay Area $169,320.00-$219,120.00 2 weeks ago Senior Scientist, Quality Control Biologics (Analytical Lifecycle Management)
Senior/Staff Scientist , NGS Assay Development
Senior Scientist, Formulation Fill/Finish
Brisbane, CA $160,164.00-$213,972.00 1 week ago Senior/Staff Scientist , NGS Assay Development
Pleasanton, CA $120,000.00-$150,000.00 3 days ago Senior / Principal Scientist, Medicinal Chemistry
South San Francisco, CA $166,000.00-$207,000.00 2 days ago Oakland, CA $125,000.00-$190,000.00 4 days ago We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.
#J-18808-Ljbffr