Eli Lilly and Company
Scientist - Oligonucleotide Developability
Eli Lilly and Company, Indianapolis, Indiana, us, 46262
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Overview
The LIGM RNA Group is seeking an experienced scientist who is independent and self-motivated, with extensive hands-on experience in drug product developability and analytical characterization for formulating drug substances based on various routes of administration, evaluating key properties including stability, to identify promising candidates and predict success in later stages of drug development. The ideal candidate will have a proven track record with parenteral formulation, liquid chromatography, mass spectrometry, and other advanced analytical techniques, and a strong background in formulation science and analytical characterization. The ability to work independently while delivering efficient, high-quality results in a fast-paced environment is essential. Responsibilities
Design, develop, and produce formulations that enable drug delivery via various routes of administration (e.g., IV, IT, and SC) to support developability evaluation at the candidate selection stage for oligonucleotides and their conjugates, including carbohydrates, lipids, small molecules, and others. Characterize solubility, and physical and chemical stability of drug candidates and formulations using various analytical techniques, including but not limited to chromatography, mass spectrometry, microscopy, thermal analysis, dynamic light scattering, pharmaceutical particle counter, and backgrounded membrane imaging. Collaborate with discovery scientists (including chemistry, analytical chemistry, ADME, toxicology, and pharmacology) to characterize the physicochemical properties of synthetic oligonucleotides to assess development potential and influence the selection of clinical drug candidates. Partner with Early Phase Oligo CMC team and drug discovery team to identify appropriate drug delivery technologies that provide the desired pharmacokinetic profile. Identify and mitigate technical risks for the performance and production of drug candidates. Demonstrate teamwork and learning agility to solve technical problems and to identify and implement novel formulations based on drug delivery technologies that improve patient benefit and Lilly value. Collaborate with, inspire, and influence the external scientific community to drive innovation, foster collaborations, and enhance Lilly's internal portfolio. Basic Qualifications
Masters degree in Pharmaceutical Sciences, Chemistry, Analytical Chemistry, Biochemistry, Biophysics, Chemical Engineering, Biomedical Engineering or similar scientific field, with at least 5 years of drug product development and characterization experience, OR Bachelors in scientific fields with at least 10 years of drug product development and characterization experience. Additional Skills/Preferences
A deep understanding of biopharmaceutics and pharmacokinetic principles, phase-appropriate formulation development, pharmaceutical material sciences, and drug product factors impacting in vivo performance and manufacturing of drug candidates. Demonstrated experience in working with parenteral formulations for oligonucleotides and their conjugates, with a deep understanding of biomolecular structure and behavior. Proficiency in biophysical and analytical characterization techniques, including but not limited to light scattering methods, chromatography, backgrounded membrane imaging, and other molecular-level characterization tools. Experience in supervising or guiding the work of other scientists. Strong teamwork, communication, and writing skills. Additional Information
This role is lab-based. This individual will have the opportunity to lead projects. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form at Lilly’s workplace accommodation page. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Learn more about all of our groups.
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The LIGM RNA Group is seeking an experienced scientist who is independent and self-motivated, with extensive hands-on experience in drug product developability and analytical characterization for formulating drug substances based on various routes of administration, evaluating key properties including stability, to identify promising candidates and predict success in later stages of drug development. The ideal candidate will have a proven track record with parenteral formulation, liquid chromatography, mass spectrometry, and other advanced analytical techniques, and a strong background in formulation science and analytical characterization. The ability to work independently while delivering efficient, high-quality results in a fast-paced environment is essential. Responsibilities
Design, develop, and produce formulations that enable drug delivery via various routes of administration (e.g., IV, IT, and SC) to support developability evaluation at the candidate selection stage for oligonucleotides and their conjugates, including carbohydrates, lipids, small molecules, and others. Characterize solubility, and physical and chemical stability of drug candidates and formulations using various analytical techniques, including but not limited to chromatography, mass spectrometry, microscopy, thermal analysis, dynamic light scattering, pharmaceutical particle counter, and backgrounded membrane imaging. Collaborate with discovery scientists (including chemistry, analytical chemistry, ADME, toxicology, and pharmacology) to characterize the physicochemical properties of synthetic oligonucleotides to assess development potential and influence the selection of clinical drug candidates. Partner with Early Phase Oligo CMC team and drug discovery team to identify appropriate drug delivery technologies that provide the desired pharmacokinetic profile. Identify and mitigate technical risks for the performance and production of drug candidates. Demonstrate teamwork and learning agility to solve technical problems and to identify and implement novel formulations based on drug delivery technologies that improve patient benefit and Lilly value. Collaborate with, inspire, and influence the external scientific community to drive innovation, foster collaborations, and enhance Lilly's internal portfolio. Basic Qualifications
Masters degree in Pharmaceutical Sciences, Chemistry, Analytical Chemistry, Biochemistry, Biophysics, Chemical Engineering, Biomedical Engineering or similar scientific field, with at least 5 years of drug product development and characterization experience, OR Bachelors in scientific fields with at least 10 years of drug product development and characterization experience. Additional Skills/Preferences
A deep understanding of biopharmaceutics and pharmacokinetic principles, phase-appropriate formulation development, pharmaceutical material sciences, and drug product factors impacting in vivo performance and manufacturing of drug candidates. Demonstrated experience in working with parenteral formulations for oligonucleotides and their conjugates, with a deep understanding of biomolecular structure and behavior. Proficiency in biophysical and analytical characterization techniques, including but not limited to light scattering methods, chromatography, backgrounded membrane imaging, and other molecular-level characterization tools. Experience in supervising or guiding the work of other scientists. Strong teamwork, communication, and writing skills. Additional Information
This role is lab-based. This individual will have the opportunity to lead projects. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form at Lilly’s workplace accommodation page. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Learn more about all of our groups.
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