Merck
Position Summary
We are seeking a highly motivated and skilled scientist to support analytical assay development, physicochemical characterization, and testing of therapeutic monoclonal antibodies. The successful candidate will contribute to lead selection for new projects and the advancement of candidates from our discovery pipeline. This hands-on role requires deep expertise in protein characterization techniques, a strong understanding of analytical assay mechanisms, and proficiency in operating and maintaining analytical instrumentation. The position is critical to the success of our therapeutic monoclonal antibody development programs.
Responsibilities
Develop and optimize analytical assays for the physicochemical characterization of monoclonal antibodies, including but not limited to: SEC; IEX; HIC; RP-HPLC; CE; cIEF.
Conduct laboratory experiments to assess the developability of monoclonal antibodies and evaluate their suitability for therapeutic use.
Provide analytical testing support to cross-functional teams, including process development, cell line development, stability studies, and product characterization.
Perform routine laboratory work and ensure proper maintenance and calibration of analytical equipment.
Document experimental procedures, results, and conclusions in laboratory notebooks and technical reports.
Present findings and progress updates to project teams and stakeholders.
Collaborate with team members to assess the quality of purified proteins and support analytical needs across the organization.
Work closely with cross-functional teams outside the group to support broader development efforts.
Qualifications Education: Bachelor’s or Master’s degree in Biochemistry, Chemistry, Biotechnology, Bioengineering, or a related discipline.
Minimum of five (5) years of experience in analytical characterization of recombinant proteins.
Hands-on experience with analytical instrumentation including liquid chromatography, capillary electrophoresis, spectrometry, PAGE gels, light scattering, and particle analysis.
Strong understanding of the principles and mechanisms of commonly used analytical techniques (e.g., SEC, IEX, HIC, RP-HPLC/UPLC).
Proficiency in laboratory software and data analysis tools relevant to downstream operations.
Excellent analytical and problem-solving skills.
Strong communication and collaboration abilities.
Ability to work independently and manage multiple projects concurrently.
Preferred Experience And Skills
Five (5)+ years of experience in antibody therapeutic discovery or development.
Experience in antibody characterization across diverse therapeutic areas.
Background in R&D of antibodies or biologics, including identification and candidate selection.
Knowledge of antibody structure-function relationships is a strong asset.
US And Puerto Rico Residents Only
Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
Requirements As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:
EEOC Know Your Rights
EEOC GINA Supplement
We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.
U.S. Hybrid Work Model Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, with Friday remote, unless business critical tasks require on-site presence. This model does not apply to field-based, facility-based, manufacturing-based, or remote roles, or roles under certain agreements.
The salary range for this role is $85,600.00 - $134,800.00. The candidate’s position within the range will be based on education, qualifications, experience, location, and business needs.
The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.
We offer a comprehensive benefits package. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.
You can apply for this role through https://jobs.merck.com/us/en. The application deadline is as stated on this posting.
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance
Search Firm Representatives Please Read Carefully: Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status: Regular
Relocation: No relocation
VISA Sponsorship: No
Travel Requirements: 10%
Flexible Work Arrangements: Not Applicable
Shift: 1st - Day
Valid Driving License: No
Hazardous Material(s): n/a
Required Skills: Accountability, Antibody Characterization, Antibody Therapeutics, Assay Development, Biochemistry, Biotechnology, Capillary Electrophoresis (CE), Cell Biology, Cell Culture Techniques, Cell Transfection, Communication, Data Analysis, Detail-Oriented, Flow Cytometry, Gel Electrophoresis, Immunochemistry, Immunocytochemistry (ICC), In Vitro Assays, Luminex Assays, Microbiology, Molecular Biology Techniques, Monoclonal Antibodies
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Responsibilities
Develop and optimize analytical assays for the physicochemical characterization of monoclonal antibodies, including but not limited to: SEC; IEX; HIC; RP-HPLC; CE; cIEF.
Conduct laboratory experiments to assess the developability of monoclonal antibodies and evaluate their suitability for therapeutic use.
Provide analytical testing support to cross-functional teams, including process development, cell line development, stability studies, and product characterization.
Perform routine laboratory work and ensure proper maintenance and calibration of analytical equipment.
Document experimental procedures, results, and conclusions in laboratory notebooks and technical reports.
Present findings and progress updates to project teams and stakeholders.
Collaborate with team members to assess the quality of purified proteins and support analytical needs across the organization.
Work closely with cross-functional teams outside the group to support broader development efforts.
Qualifications Education: Bachelor’s or Master’s degree in Biochemistry, Chemistry, Biotechnology, Bioengineering, or a related discipline.
Minimum of five (5) years of experience in analytical characterization of recombinant proteins.
Hands-on experience with analytical instrumentation including liquid chromatography, capillary electrophoresis, spectrometry, PAGE gels, light scattering, and particle analysis.
Strong understanding of the principles and mechanisms of commonly used analytical techniques (e.g., SEC, IEX, HIC, RP-HPLC/UPLC).
Proficiency in laboratory software and data analysis tools relevant to downstream operations.
Excellent analytical and problem-solving skills.
Strong communication and collaboration abilities.
Ability to work independently and manage multiple projects concurrently.
Preferred Experience And Skills
Five (5)+ years of experience in antibody therapeutic discovery or development.
Experience in antibody characterization across diverse therapeutic areas.
Background in R&D of antibodies or biologics, including identification and candidate selection.
Knowledge of antibody structure-function relationships is a strong asset.
US And Puerto Rico Residents Only
Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
Requirements As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:
EEOC Know Your Rights
EEOC GINA Supplement
We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.
U.S. Hybrid Work Model Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, with Friday remote, unless business critical tasks require on-site presence. This model does not apply to field-based, facility-based, manufacturing-based, or remote roles, or roles under certain agreements.
The salary range for this role is $85,600.00 - $134,800.00. The candidate’s position within the range will be based on education, qualifications, experience, location, and business needs.
The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.
We offer a comprehensive benefits package. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.
You can apply for this role through https://jobs.merck.com/us/en. The application deadline is as stated on this posting.
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance
Search Firm Representatives Please Read Carefully: Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status: Regular
Relocation: No relocation
VISA Sponsorship: No
Travel Requirements: 10%
Flexible Work Arrangements: Not Applicable
Shift: 1st - Day
Valid Driving License: No
Hazardous Material(s): n/a
Required Skills: Accountability, Antibody Characterization, Antibody Therapeutics, Assay Development, Biochemistry, Biotechnology, Capillary Electrophoresis (CE), Cell Biology, Cell Culture Techniques, Cell Transfection, Communication, Data Analysis, Detail-Oriented, Flow Cytometry, Gel Electrophoresis, Immunochemistry, Immunocytochemistry (ICC), In Vitro Assays, Luminex Assays, Microbiology, Molecular Biology Techniques, Monoclonal Antibodies
#J-18808-Ljbffr