Axle Informatics LLC
High-Performance Computing (HPC) Systems Engineer Rockville, MD
Axle Informatics LLC, Rockville, Maryland, us, 20849
High-Performance Computing (HPC) Systems Engineer
(ID: 2025-0683) Axle
is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH). Axle
is seeking a
High-Performance Computing (HPC) Systems Engineer
to join our vibrant team at the National Institutes of Health (NIH) supporting the The National Center for Advancing Translational Sciences (NCATS) located in Rockville, MD. Benefits We Offer: Paid Time Off and Paid Holidays 401K match up to 5% Educational Benefits for Career Growth Employee Referral Bonus Flexible Spending Accounts: Healthcare (FSA) Parking Reimbursement Account (PRK) Dependent Care Assistant Program (DCAP) Transportation Reimbursement Account (TRN) Overview
The High-Performance Computing (HPC) Systems Engineer will support the Scientific Computing and Informatics (SCI) team at The National Center for Advancing Translational Sciences (NCATS). This role will focus on the design, optimization, security, and maintenance of HPC and cloud-based infrastructures that enable cutting-edge biomedical research through scalable, secure, and high-performing computing environments. Responsibilities
Design, configure, and maintain scalable HPC clusters for optimal performance. Support documentation and ATO (Authority to Operate) processes. Ensure infrastructure design compliance with federal security standards and best practices. Implement monitoring tools such as XDMoD for transparency and user reporting. Integrate platforms such as JupyterHub and job schedulers (e.g., Slurm) for improved interactivity. Develop and manage AWS-based infrastructure using Terraform, Packer, and Ansible. Automate deployment workflows to streamline provisioning, updates, and scaling. Manage systems involved in AWS Secure Cloud Bridging (SCB) and STRIDES initiatives. Implement CIS benchmark-aligned system hardening using OpenSCAP. Administer optimized compute images (CPU/GPU) for scientific workflows. Leverage tools such as OpenHPC, Warewulf, and Ansible for environment management. Lead and coordinate quarterly patch cycles. Partner with researchers and external stakeholders on critical projects. Facilitate solution transitions to other NIH centers and collaborators. Contribute to publications and team objectives through deep technical engagement. Qualifications
Federal ATO processes experience required HPC architecture and performance optimization is required Scientific software development and deployment High-speed network and parallel file system architecture Troubleshooting, diagnostics, and technical support Strong communication and multitasking skills Programming & Scripting: Languages - Pascal, BASIC, Delphi, Visual Basic, C, C++ Scripting - Bash, Perl, Python, Ruby, PEAR, Tcl Systems & Network Administration: Windows – 95–10; NT–Server 2016 Networking – Active Directory, TCP/IP v4/v6, DHCP, DNS, WINS Legacy – NOVELL 3.1–5, VPN, Citrix, Terminal Services Monitoring & Management Tools: Infrastructure & Automation: Red Hat Satellite, Kickstart, RPM optimization File Systems & Archiving: HPC Tools & Job Scheduling: Nice DCV, EnginFrame, VNC, OpenText Exceed OnDemand, Web Remote Desktop Containerization & GPU: Databases: SQL Server (2000–2008), MySQL, Zope High-Speed Networking: HPC architecture and performance tuning Cybersecurity in HPC/cloud environments Infrastructure as Code (AWS, Terraform, Ansible, Packer) Supporting scientific workflows in research environments Disclaimer
The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed. The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination. Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location. #INDPSD Salary Range $150,000 - $160,000 USD
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(ID: 2025-0683) Axle
is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH). Axle
is seeking a
High-Performance Computing (HPC) Systems Engineer
to join our vibrant team at the National Institutes of Health (NIH) supporting the The National Center for Advancing Translational Sciences (NCATS) located in Rockville, MD. Benefits We Offer: Paid Time Off and Paid Holidays 401K match up to 5% Educational Benefits for Career Growth Employee Referral Bonus Flexible Spending Accounts: Healthcare (FSA) Parking Reimbursement Account (PRK) Dependent Care Assistant Program (DCAP) Transportation Reimbursement Account (TRN) Overview
The High-Performance Computing (HPC) Systems Engineer will support the Scientific Computing and Informatics (SCI) team at The National Center for Advancing Translational Sciences (NCATS). This role will focus on the design, optimization, security, and maintenance of HPC and cloud-based infrastructures that enable cutting-edge biomedical research through scalable, secure, and high-performing computing environments. Responsibilities
Design, configure, and maintain scalable HPC clusters for optimal performance. Support documentation and ATO (Authority to Operate) processes. Ensure infrastructure design compliance with federal security standards and best practices. Implement monitoring tools such as XDMoD for transparency and user reporting. Integrate platforms such as JupyterHub and job schedulers (e.g., Slurm) for improved interactivity. Develop and manage AWS-based infrastructure using Terraform, Packer, and Ansible. Automate deployment workflows to streamline provisioning, updates, and scaling. Manage systems involved in AWS Secure Cloud Bridging (SCB) and STRIDES initiatives. Implement CIS benchmark-aligned system hardening using OpenSCAP. Administer optimized compute images (CPU/GPU) for scientific workflows. Leverage tools such as OpenHPC, Warewulf, and Ansible for environment management. Lead and coordinate quarterly patch cycles. Partner with researchers and external stakeholders on critical projects. Facilitate solution transitions to other NIH centers and collaborators. Contribute to publications and team objectives through deep technical engagement. Qualifications
Federal ATO processes experience required HPC architecture and performance optimization is required Scientific software development and deployment High-speed network and parallel file system architecture Troubleshooting, diagnostics, and technical support Strong communication and multitasking skills Programming & Scripting: Languages - Pascal, BASIC, Delphi, Visual Basic, C, C++ Scripting - Bash, Perl, Python, Ruby, PEAR, Tcl Systems & Network Administration: Windows – 95–10; NT–Server 2016 Networking – Active Directory, TCP/IP v4/v6, DHCP, DNS, WINS Legacy – NOVELL 3.1–5, VPN, Citrix, Terminal Services Monitoring & Management Tools: Infrastructure & Automation: Red Hat Satellite, Kickstart, RPM optimization File Systems & Archiving: HPC Tools & Job Scheduling: Nice DCV, EnginFrame, VNC, OpenText Exceed OnDemand, Web Remote Desktop Containerization & GPU: Databases: SQL Server (2000–2008), MySQL, Zope High-Speed Networking: HPC architecture and performance tuning Cybersecurity in HPC/cloud environments Infrastructure as Code (AWS, Terraform, Ansible, Packer) Supporting scientific workflows in research environments Disclaimer
The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed. The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination. Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location. #INDPSD Salary Range $150,000 - $160,000 USD
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