Alnylam Pharmaceuticals
Principal Associate Scientist, Research (RNAi Biology & siRNA Delivery)
Alnylam Pharmaceuticals, Cambridge, Massachusetts, us, 02140
Overview
The Research Department at Alnylam is seeking a passionate and enthusiastic Principal Associate Scientist to join our interdisciplinary team focused on advancing extrahepatic siRNA delivery and our mechanistic understanding of RNAi biology across tissues, specifically skeletal muscle, heart, and kidney. The role requires a strong background in biological sciences and technical skillsets in in vitro cell culture as well as molecular and biochemical assays. Prior experience or a willingness to learn in vivo rodent work is strongly preferred. We seek someone who will flourish in a goal- and timeline-oriented collaborative environment and be able to rapidly learn new topics and experimental techniques. This position is lab-based
onsite
and will be primarily located in Cambridge, MA.
Key Responsibilities
The candidate will engage in a variety of mechanistic in vitro and in vivo siRNA research efforts to evaluate RNAi compounds, utilizing biochemical, molecular, and cell-based assays.
Design, execution, interpretation, and troubleshooting of experiments on an individual basis as well as part of a collaborative team.
Presentation of results in both written and oral format to key stakeholders within the Research organization.
Qualifications
BS/MS in Biology, Biochemistry, or related field with 6+ (BS) or 4+ (MS) years of work experience, preferably in industry setting.
Prior experience and/or working knowledge of nucleic acid-based therapies (siRNA, ASO, CRISPR) is highly desired.
Proficiency in mammalian immortalized and primary cell culture (maintenance, transfection/stable selection).
Proficiency in DNA/RNA sequence evaluation and plasmid design.
Proficiency in routine molecular biology assays to support evaluation of siRNA activity (qPCR, Western Blotting, ELISA, Ago-immunoprecipitation, etc.).
Prior experience with advanced cell models, including generation and/or CRISPR editing of iPSC-derived cell lines would be highly valuable.
Molecular biology assays to support evaluation of siRNA activity (qPCR, Western blotting, ELISA, Ago-immunoprecipitation, etc.).
Experience with (or willingness to learn) in vivo rodent handling and experimentation is a plus.
Excellent lab technique and ability to work independently.
Strong interpersonal and communication skills (written and oral) are required.
U.S. Pay Range $97,300.00 - $137,100.00
The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award and an annual long-term incentive award. Alnylam’s Total Rewards package includes medical, dental, vision, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts, and a 401(k) with company match. Eligible employees receive paid time off, wellness days, holidays, and two company-wide recharge breaks. Our commitment to well-being reflects that caring for our people fuels the impact we create together.
About Alnylam We are the leader in RNAi therapeutics—an approach with the potential to transform lives. Built on Nobel Prize-winning science, Alnylam has delivered breakthroughs that made RNAi therapeutics possible. Our pipeline, programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We’re proud to be a globally recognized top employer with an authentic, inclusive culture and breakthrough thinking.
We commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration without regard to sex, gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, disability, pregnancy status, genetic information, veteran or military status, marital status, political affiliation, age, or other protected status. Alnylam is an E-Verify Employer.
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onsite
and will be primarily located in Cambridge, MA.
Key Responsibilities
The candidate will engage in a variety of mechanistic in vitro and in vivo siRNA research efforts to evaluate RNAi compounds, utilizing biochemical, molecular, and cell-based assays.
Design, execution, interpretation, and troubleshooting of experiments on an individual basis as well as part of a collaborative team.
Presentation of results in both written and oral format to key stakeholders within the Research organization.
Qualifications
BS/MS in Biology, Biochemistry, or related field with 6+ (BS) or 4+ (MS) years of work experience, preferably in industry setting.
Prior experience and/or working knowledge of nucleic acid-based therapies (siRNA, ASO, CRISPR) is highly desired.
Proficiency in mammalian immortalized and primary cell culture (maintenance, transfection/stable selection).
Proficiency in DNA/RNA sequence evaluation and plasmid design.
Proficiency in routine molecular biology assays to support evaluation of siRNA activity (qPCR, Western Blotting, ELISA, Ago-immunoprecipitation, etc.).
Prior experience with advanced cell models, including generation and/or CRISPR editing of iPSC-derived cell lines would be highly valuable.
Molecular biology assays to support evaluation of siRNA activity (qPCR, Western blotting, ELISA, Ago-immunoprecipitation, etc.).
Experience with (or willingness to learn) in vivo rodent handling and experimentation is a plus.
Excellent lab technique and ability to work independently.
Strong interpersonal and communication skills (written and oral) are required.
U.S. Pay Range $97,300.00 - $137,100.00
The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award and an annual long-term incentive award. Alnylam’s Total Rewards package includes medical, dental, vision, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts, and a 401(k) with company match. Eligible employees receive paid time off, wellness days, holidays, and two company-wide recharge breaks. Our commitment to well-being reflects that caring for our people fuels the impact we create together.
About Alnylam We are the leader in RNAi therapeutics—an approach with the potential to transform lives. Built on Nobel Prize-winning science, Alnylam has delivered breakthroughs that made RNAi therapeutics possible. Our pipeline, programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We’re proud to be a globally recognized top employer with an authentic, inclusive culture and breakthrough thinking.
We commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration without regard to sex, gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, disability, pregnancy status, genetic information, veteran or military status, marital status, political affiliation, age, or other protected status. Alnylam is an E-Verify Employer.
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