BioSpace
Join Amgen's Mission of Serving Patients
At Amgen, our shared mission to serve patients living with serious illnesses drives all that we do. Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases.
Our award-winning culture is collaborative, innovative, and science-based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team.
Job Description
We are seeking a highly motivated Scientist to join the Structural Biology Department at our Thousand Oaks, CA location. The Structural Biology laboratory plays a key role in providing comprehensive molecular insights and structure-based design for drug-target assessment, mechanism of action, protein-protein and protein-ligand interactions, and protein engineering. In this vital role, you will be responsible for designing, planning, and executing the generation of key enabling reagents that support the structure determination of target molecules via X-ray crystallography and/or cryo-electron microscopy (cryo-EM). Key Responsibilities
Protein Biochemistry: Design and execution of molecular cloning and protein expression strategies; design and execution of purification strategies to support the structure determination of drug targets. Collaborative Support: Work closely with structural biologists to generate high-quality protein samples for structural biology techniques. Method Development: Develop and optimize purification protocols and reagents, ensuring high protein purity, homogeneity, and stability for structural studies. Characterization and Quality Control: Use biochemical and biophysical techniques to assess protein quality and stability. Project Management: Manage multiple projects simultaneously, ensuring they are completed within timelines while meeting high-quality standards. Team Communication: Present research findings effectively in both written and oral formats for internal teams and external collaborators. Innovative Thinking: Continuously troubleshoot and optimize experimental workflows, applying creative solutions to overcome challenges in protein production and purification. Basic Qualifications
Doctorate degree in Biochemistry, Molecular Biology, Structural Biology, or a related field Or Master's degree and 2 years of Biochemistry, Molecular Biology, Structural Biology, or a related field experience Or Bachelor's degree and 4 years of Biochemistry, Molecular Biology, Structural Biology, or a related field experience Preferred Qualifications
Experience with microbial systems or cell culture for protein expression. Hands-on experience with biochemical analytical techniques such as spectrophotometry, SDS-PAGE, Western blot, SEC-MALS, SPR, and basic mass spectrometry. Familiarity with chromatography systems and related software. Expertise in protein purification methods, including affinity, ion exchange, hydrophobic interaction, and size-exclusion chromatography. Experience with biophysical characterization of protein complexes, including techniques like dynamic light scattering and analytical ultracentrifugation. Strong knowledge of protein stability, folding, and quality control for structural studies. Excellent presentation skills to effectively communicate research results to both scientific and cross-functional teams. What We Offer
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way. The expected annual salary range for this role in the U.S. is $80,000 - $130,000. Equal Opportunity Employer
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
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We are seeking a highly motivated Scientist to join the Structural Biology Department at our Thousand Oaks, CA location. The Structural Biology laboratory plays a key role in providing comprehensive molecular insights and structure-based design for drug-target assessment, mechanism of action, protein-protein and protein-ligand interactions, and protein engineering. In this vital role, you will be responsible for designing, planning, and executing the generation of key enabling reagents that support the structure determination of target molecules via X-ray crystallography and/or cryo-electron microscopy (cryo-EM). Key Responsibilities
Protein Biochemistry: Design and execution of molecular cloning and protein expression strategies; design and execution of purification strategies to support the structure determination of drug targets. Collaborative Support: Work closely with structural biologists to generate high-quality protein samples for structural biology techniques. Method Development: Develop and optimize purification protocols and reagents, ensuring high protein purity, homogeneity, and stability for structural studies. Characterization and Quality Control: Use biochemical and biophysical techniques to assess protein quality and stability. Project Management: Manage multiple projects simultaneously, ensuring they are completed within timelines while meeting high-quality standards. Team Communication: Present research findings effectively in both written and oral formats for internal teams and external collaborators. Innovative Thinking: Continuously troubleshoot and optimize experimental workflows, applying creative solutions to overcome challenges in protein production and purification. Basic Qualifications
Doctorate degree in Biochemistry, Molecular Biology, Structural Biology, or a related field Or Master's degree and 2 years of Biochemistry, Molecular Biology, Structural Biology, or a related field experience Or Bachelor's degree and 4 years of Biochemistry, Molecular Biology, Structural Biology, or a related field experience Preferred Qualifications
Experience with microbial systems or cell culture for protein expression. Hands-on experience with biochemical analytical techniques such as spectrophotometry, SDS-PAGE, Western blot, SEC-MALS, SPR, and basic mass spectrometry. Familiarity with chromatography systems and related software. Expertise in protein purification methods, including affinity, ion exchange, hydrophobic interaction, and size-exclusion chromatography. Experience with biophysical characterization of protein complexes, including techniques like dynamic light scattering and analytical ultracentrifugation. Strong knowledge of protein stability, folding, and quality control for structural studies. Excellent presentation skills to effectively communicate research results to both scientific and cross-functional teams. What We Offer
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way. The expected annual salary range for this role in the U.S. is $80,000 - $130,000. Equal Opportunity Employer
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
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