The Phage
Metaphore is seeking a Senior Scientist with expertise in recombinant DNA technologies, vector design, and phage/yeast/mammalian display systems. In this role, you will lead the design and generation of plasmid constructs, antibodies, protein libraries, and molecular display platforms to advance therapeutic discovery efforts.
Vector Design & Molecular Cloning
Design and construct expression vectors (plasmid/viral) for gene expression, knockdown, and editing. Apply traditional and high-throughput cloning techniques (e.g., Gibson Assembly, Golden Gate, Gateway). Display Library Engineering
Engineer phage, yeast, and mammalian display libraries (e.g., scFv, Fab, sdAb, and other related nanobodies). Develop and execute biopanning and affinity maturation strategies. Implement technologies such as deep mutational scanning (DMS) and massively parallel reporter assays (MPRA) to generate data for the company’s machine learning-driven platform. Analyze data using Python, R, and Linux-based bioinformatics tools. For more phage-related global research and job opportunities, click here
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Design and construct expression vectors (plasmid/viral) for gene expression, knockdown, and editing. Apply traditional and high-throughput cloning techniques (e.g., Gibson Assembly, Golden Gate, Gateway). Display Library Engineering
Engineer phage, yeast, and mammalian display libraries (e.g., scFv, Fab, sdAb, and other related nanobodies). Develop and execute biopanning and affinity maturation strategies. Implement technologies such as deep mutational scanning (DMS) and massively parallel reporter assays (MPRA) to generate data for the company’s machine learning-driven platform. Analyze data using Python, R, and Linux-based bioinformatics tools. For more phage-related global research and job opportunities, click here
#J-18808-Ljbffr