University of California
Scientist, Aging Metabolism
University of California, South San Francisco, California, us, 94083
Calico is seeking a highly motivated scientist to join and lead discovery research projects in the metabolism of aging group. Specifically, we are interested in applicants with a long-term interest in understanding metabolic mechanisms in normal physiology and pathology, including cancer. We seek expertise in combining cutting-edge molecular and biochemical techniques, including transcriptomics and metabolomics, with
in vitro
and
in vivo
models to uncover metabolic interactions in health and disease. Join our collaborative, cross-functional environment at the forefront of aging research, work alongside world-class technology labs, and lead ambitious research projects that could transform our understanding of aging. Responsibilities: Perform basic research to determine metabolic mechanisms underlying aging process Develop approaches to evaluate metabolic interactions between specific cell types during aging Publish papers and present findings both internally and at scientific conferences Position Requirements: PhD or MD/PhD in cell/molecular biology, biochemistry or a related field with 0-5 years of postdoctoral and/or industry experience Experience working with animal models to study human disease and/or aging Deep knowledge of cellular and organismal metabolism and physiology Strong working knowledge of genetics, cell biology and molecular genetics Detail-oriented, organized and driven A track record of strong research productivity Strong teamwork and communication skills Flexible, able to respond quickly to shifting priorities and able to multitask Must be willing to work onsite five days per week Nice to Have: Experience with mass spectrometry to measure metabolites and/or lipids and/or proteins Experience using stable isotope labeling to understand metabolic fluxes
in vitro
and/or
in vivo Experience with integrating multiomics data Expertise in immune biology and immune cell cultures Competence with mammalian tissue culture,
in vitro
gene editing techniques (CRISPR/Cas9, viral transduction) and basic molecular biology methods Familiarity with R or Python for data analysis and visualization The estimated base salary range for this role is $127,000 - $155,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses. Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives.
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in vitro
and
in vivo
models to uncover metabolic interactions in health and disease. Join our collaborative, cross-functional environment at the forefront of aging research, work alongside world-class technology labs, and lead ambitious research projects that could transform our understanding of aging. Responsibilities: Perform basic research to determine metabolic mechanisms underlying aging process Develop approaches to evaluate metabolic interactions between specific cell types during aging Publish papers and present findings both internally and at scientific conferences Position Requirements: PhD or MD/PhD in cell/molecular biology, biochemistry or a related field with 0-5 years of postdoctoral and/or industry experience Experience working with animal models to study human disease and/or aging Deep knowledge of cellular and organismal metabolism and physiology Strong working knowledge of genetics, cell biology and molecular genetics Detail-oriented, organized and driven A track record of strong research productivity Strong teamwork and communication skills Flexible, able to respond quickly to shifting priorities and able to multitask Must be willing to work onsite five days per week Nice to Have: Experience with mass spectrometry to measure metabolites and/or lipids and/or proteins Experience using stable isotope labeling to understand metabolic fluxes
in vitro
and/or
in vivo Experience with integrating multiomics data Expertise in immune biology and immune cell cultures Competence with mammalian tissue culture,
in vitro
gene editing techniques (CRISPR/Cas9, viral transduction) and basic molecular biology methods Familiarity with R or Python for data analysis and visualization The estimated base salary range for this role is $127,000 - $155,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses. Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives.
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