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Califesciences

Sr. Bioinformatics Scientist

Califesciences, California, Missouri, United States, 65018

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At Veracyte, we offer exciting career opportunities for those interested in joining a pioneering team that is committed to transforming cancer care for patients across the globe. Working at Veracyte enables our employees to not only make a meaningful impact on the lives of patients, but to also learn and grow within a purpose driven environment. This is what we call the Veracyte way; it is about how we work together, guided by our values, to give clinicians the insights they need to help patients make life-changing decisions. Our Values: We Seek A Better Way : We innovate boldly, learn from our setbacks, and are resilient in our pursuit to transform cancer care We Make It Happen : We act with urgency, commit to quality, and bring fun to our hard work We Are Stronger Together : We collaborate openly, seek to understand, and celebrate our wins We Care Deeply : We embrace our differences, do the right thing, and encourage each other The Position:

This can be a hybrid position based out of our San Diego office, South San Francisco office, or remote. We are seeking an experienced and motivated Bioinformatics Scientist to join our Bioinformatics and Data Science Team focused on developing regulated diagnostics products. The ideal candidate will bring deep expertise in NGS technologies with a strong understanding of regulatory environments including CAP/CLIA and IVD product development. The successful candidate will play a crucial role in designing, developing, and optimizing our next generation of genomic assays. This position requires a unique blend of expertise in bioinformatics, extensive experience in assay optimization, analytical validation, strong skills in analytical pipeline development, automation and optimization, a deep understanding of molecular biology, and a passion for transforming complex biological data into actionable insights. Responsibilities

Lead bioinformatics design, development and validation efforts in assay development for new and on-market products. As part of project core teams, coordinate planning, execution, and delivery within timelines and budget constraints. Apply leading edge knowledge in bioinformatics, genomics, and assay technologies to contribute to development objectives in creative and effective ways. Drive development study design and all analyses for assay development efforts in collaboration with cross-functional teams. Develop statistical and machine learning techniques to evaluate assay performance and create optimization strategies. Communicate analysis results, methodologies, and scientific findings to internal teams, external collaborators, and stakeholders. Develop scalable, production-grade workflows for high-throughput NGS data analysis using AWS and containerized environments. Facilitate successful production pipeline deployment by working closely with infrastructure and engineering teams. Ensure compliance with regulatory standards (CAP/CLIA, FDA, IVDR) throughout the bioinformatics development lifecycle, including rigorous testing and documentation. Contribute to regulatory submissions and audits by providing technical documentation and validation reports. Provide scientific guidance and mentorship to junior bioinformatics team members. Who You Are

REQUIRED EXPERIENCE: PhD or MS in bioinformatics, computational biology, or an adjacent data science field, such as biostatistics, statistics or computer science. Minimum of 6–7 years of experience in bioinformatics analysis, algorithm development, and pipeline implementation. Thorough understanding of NGS technologies and library preparation methods (WGS, enrichment, RNA-Seq, methylation, etc.). Proficiency in quantitative transcriptomics from NGS or expression microarray data in human disease/biology, including differential expression, dimensionality reduction, expression-based classifier development, RNA-based signatures, cell type deconvolution. Proficiency in machine learning, development of novel bioinformatics methodologies, and algorithm development, including benchmarking of computational methods. Experience deploying bioinformatics workflows in AWS (e.g., EC2, S3, Step Functions, Batch, Lambda). Strong proficiency in Python, including testing frameworks and SDLC best practices. Collaborates closely with Quality and Regulatory Affairs on assay and analysis pipeline development and verification. Demonstrated technical and scientific leadership, ownership, and ability to work independently. RELEVANT EXPERIENCE (preferred but not required): Track record of working with wet lab scientists on iterative experiment design, execution, analysis, and interpretation as part of an integrated team. Proficiency in genomics, sequence analysis, and secondary analysis (variant calling, CNV, SVs), NGS QC, splicing, circular nucleic acids. Understanding of germline and somatic mutation processes and biomarkers with potential clinical utility (e.g., TMB, mutational signatures, LOH). Working knowledge of R. Experience with relational and non-relational database technologies is a plus. Excellent communicator of complex technical topics in an interdisciplinary setting, with data visualizations. Strong technical problem solving and troubleshooting skills. #LI-Hybrid The final salary offered to a successful candidate will be dependent on experience and other factors. Base pay is part of the Total Package and may include discretionary bonuses/incentives and restricted stock units. Veracyte is a multi-state employer; salary ranges may reflect positions in different states. Pay range $170,000



$180,000 USD What We Can Offer You

Veracyte is a growing company that offers significant career opportunities for curious, driven, patient-oriented individuals who aspire to help build a great company. We offer competitive compensation and benefits and are committed to fostering an inclusive workforce. We are recognized as a 2024 Certified Great Place to Work in the US and Israel. About Veracyte

Veracyte (Nasdaq: VCYT) is a global genomic diagnostics company that improves patient care by providing answers to clinical questions and informing diagnosis and treatment decisions in cancer and other diseases. Our growing menu of genomic tests leverages advances in genomic science and technology, enabling patients to avoid risky, costly diagnostic procedures and shorten time to appropriate treatment. Our tests cover lung, prostate, breast, thyroid, bladder cancers, and idiopathic pulmonary fibrosis; lymphoma subtyping and renal cancer tests are in development. Veracyte is based in South San Francisco, California. For more information, visit

www.veracyte.com

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X (formerly Twitter) . Veracyte, Inc. is an Equal Opportunity Employer and will consider all qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status or disability status. Veracyte participates in E-Verify. View our

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