Ionis Pharmaceuticals, Inc.
Senior Bioanalytical Scientist
Ionis Pharmaceuticals, Inc., California, Missouri, United States, 65018
Overview
Headquartered in Carlsbad, California, Ionis has offices in Boston, Massachusetts, and Dublin, Ireland. Ionis is a pioneer in RNA-targeted medicines with a leading pipeline in neurology, cardiology and select high-need areas, focused on advancing RNA therapies and gene editing approaches to provide greater value to patients. Ionis is committed to a diverse, innovative and collaborative culture with onsite, hybrid and remote work options.
We’re building on our rich history and invite you to apply if you’re passionate about having a meaningful impact on patients in need.
Position SENIOR BIOANALYTICAL SCIENTIST
Summary:
We are seeking a highly skilled and motivated Sr. Bioanalytical Scientist with senior expertise in method development for ligand binding assays (LBAs). This role involves designing, developing new bioanalytical assays, optimization and testing LBA-based assays for RNA therapeutics and related novel modalities to support non-regulated pharmacokinetic (PK), toxicokinetic (TK), and ADA with minimal guidance. The ideal candidate will possess strong technical proficiency, independent problem-solving skills, and a collaborative mindset. This position is onsite and lab-based, involves approximately 90% laboratory work and 10% office-based tasks. The candidate must be comfortable working in a fast-paced environment that requires attention to detail and adaptability and change of priorities.
Responsibilities
Method Development :
Design and develop new assays from scratch.
Optimize ligand binding assays (e.g. MSD, ELISA) with a focus on sensitivity, specificity, linearity, reproducibility and robustness.
Independently troubleshoot assay performance issues and implement improvements.
Write a detailed protocol of the methods developed to use in sample analysis.
Data Analysis & Reporting :
Document the experimental design and execution in ELN.
Analyze experimental data using appropriate statistical tools.
Prepare PowerPoint presentations and summarize results in technical reports, when needed.
Present findings to internal teams and external stakeholders.
Work closely with cross-functional teams, including pharmacology and medicinal chemistry.
Provide procedural training and mentorship to junior scientists.
Support colleagues on sample analysis as needed.
Requirements
Ph.D. in Biochemistry, Biology, Analytical Chemistry, or a related field with a minimum of 2–5 years of bioanalytical experience as a post-doctoral fellow or scientist in biotech/pharma.
Proficiency in troubleshooting and optimizing bioanalytical methods.
Advanced knowledge and hands-on experience with ligand binding assay formats (e.g., ELISA, Solid).
Experience developing bioanalytical assays (e.g., ELISA, MSD) for quantification of antisense oligonucleotides or siRNA is a plus.
Experience with bioanalytical instruments such as LC/MS is a plus.
Familiarity with bioanalytical method validation guidance (e.g., FDA, EMA, ICH M10).
Experience with lab automation technologies.
Strong technical writing skills for documentation and reporting.
Proven ability to manage multiple projects simultaneously.
Effective communication skills for presentations and team collaboration.
Please visit our website, http://www.ionis.com for more information about Ionis and to apply for this position; reference requisition # IONIS003806.
Ionis offers an excellent benefits package. Follow this link for details:
Ionis Benefits
The pay scale for this position is $116,707.00 to $151,565.00.
NO PHONE CALLS PLEASE. PRINCIPALS ONLY.
Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.
Equal Opportunity This employer is an Equal Opportunity Employer. This notice is provided pursuant to federal employment laws. For more information, review the Know Your Rights notice from the Department of Labor.
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We’re building on our rich history and invite you to apply if you’re passionate about having a meaningful impact on patients in need.
Position SENIOR BIOANALYTICAL SCIENTIST
Summary:
We are seeking a highly skilled and motivated Sr. Bioanalytical Scientist with senior expertise in method development for ligand binding assays (LBAs). This role involves designing, developing new bioanalytical assays, optimization and testing LBA-based assays for RNA therapeutics and related novel modalities to support non-regulated pharmacokinetic (PK), toxicokinetic (TK), and ADA with minimal guidance. The ideal candidate will possess strong technical proficiency, independent problem-solving skills, and a collaborative mindset. This position is onsite and lab-based, involves approximately 90% laboratory work and 10% office-based tasks. The candidate must be comfortable working in a fast-paced environment that requires attention to detail and adaptability and change of priorities.
Responsibilities
Method Development :
Design and develop new assays from scratch.
Optimize ligand binding assays (e.g. MSD, ELISA) with a focus on sensitivity, specificity, linearity, reproducibility and robustness.
Independently troubleshoot assay performance issues and implement improvements.
Write a detailed protocol of the methods developed to use in sample analysis.
Data Analysis & Reporting :
Document the experimental design and execution in ELN.
Analyze experimental data using appropriate statistical tools.
Prepare PowerPoint presentations and summarize results in technical reports, when needed.
Present findings to internal teams and external stakeholders.
Work closely with cross-functional teams, including pharmacology and medicinal chemistry.
Provide procedural training and mentorship to junior scientists.
Support colleagues on sample analysis as needed.
Requirements
Ph.D. in Biochemistry, Biology, Analytical Chemistry, or a related field with a minimum of 2–5 years of bioanalytical experience as a post-doctoral fellow or scientist in biotech/pharma.
Proficiency in troubleshooting and optimizing bioanalytical methods.
Advanced knowledge and hands-on experience with ligand binding assay formats (e.g., ELISA, Solid).
Experience developing bioanalytical assays (e.g., ELISA, MSD) for quantification of antisense oligonucleotides or siRNA is a plus.
Experience with bioanalytical instruments such as LC/MS is a plus.
Familiarity with bioanalytical method validation guidance (e.g., FDA, EMA, ICH M10).
Experience with lab automation technologies.
Strong technical writing skills for documentation and reporting.
Proven ability to manage multiple projects simultaneously.
Effective communication skills for presentations and team collaboration.
Please visit our website, http://www.ionis.com for more information about Ionis and to apply for this position; reference requisition # IONIS003806.
Ionis offers an excellent benefits package. Follow this link for details:
Ionis Benefits
The pay scale for this position is $116,707.00 to $151,565.00.
NO PHONE CALLS PLEASE. PRINCIPALS ONLY.
Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.
Equal Opportunity This employer is an Equal Opportunity Employer. This notice is provided pursuant to federal employment laws. For more information, review the Know Your Rights notice from the Department of Labor.
#J-18808-Ljbffr