Merck
Principal Scientist (Director), Anatomic Pathologist
Merck, West Point, Nebraska, United States, 68788
Overview
Translational Molecular Biomarkers is responsible for translating preclinical molecular biomarkers to clinical development across all therapeutic areas and all phases of clinical development at our company's Research Laboratories. Translational Molecular Biomarkers laboratories leverage a diverse array of technologies to develop biomarker assays to help confirm engagement of therapeutic targets and understand mechanisms of drug action and patient response. The Molecular Pathology group within the Translational Molecular Biomarkers organization is seeking a highly motivated and experienced Anatomic Pathologist (MD) for the role of Principal Scientist (Director) to join our innovative team. This position will play a crucial role in supporting the development, analytical validation, and testing of histopathology-based assays for clinical implementation and advancing digital pathology within our company\'s clinical therapeutic pipeline. Principal Scientist (Director)
will have the following responsibilities: Engage in providing thorough histopathological reviews and testing clinical samples, leveraging expertise in disease processes and pathways targeted by our company\'s therapeutics. Collaborate in the development and analytic validation of digital pathology algorithms. Interface with scientists and physicians in early and late-stage clinical development to execute histopathology-based biomarker strategies in clinical trials. Establish new histopathology-based assays in the laboratory as part of a team. Provide expert pathologist input to discussions in a highly matrixed environment, collaborating with internal and external stakeholders. Position Qualifications
Education Minimum Requirement : Doctor of Medicine (MD or MD/PhD) with specialized training in Anatomic Pathology. Required Experience and Skills : Proficient in routine histopathology testing, immunohistochemistry (IHC), cytogenetics (in-situ hybridization) testing procedures, and applicable laboratory testing regulations. Experience ensuring compliance of a clinical laboratory with regulatory standards. Experience with the development and analytic validation of digital pathology algorithms. Excellent oral and written skills with a proven record of scientific contributions to the scientific community. Demonstrated ability to lead and manage projects in a fast-paced environment. Ability to interact well with diverse groups and maintain strong working relationships with internal and external collaborators. Strong understanding of disease processes and pathways relevant to our company\'s therapeutics. Preferred Experience and Skills : Experience working in the pharmaceutical industry. Broad knowledge of the drug development process and translational medicine. Experience in clinical biomarker development or managing the implementation of biomarker assays in support of drug development. Experience with multiplex tissue-based spatial profiling assays (e.g., multiplex immunofluorescence, multiplex chromogenic immunohistochemistry, imaging mass cytometry). Familiarity with image acquisition platforms (e.g., Leica Aperio, Hamamatsu, Pannoramic). Proficiency in commercial or open-source image analysis software packages (e.g., Visiopharm, HALO, QuPath). Knowledge of using statistical software packages (e.g., Prism, SPSS). Understanding of regulated clinical bioanalysis. Required Skills:
Anatomic Pathology, Biomarker Development, Clinical Studies, Digital Pathology, Molecular Pathology Preferred Skills: Current Employees apply HERE. Current Contingent Workers apply HERE. Additional Information
US and Puerto Rico Residents Only:
Our company is committed to inclusion and provides accommodations during the application or hiring process if needed. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, please visit the EEOC Know Your Rights and EEOC GINA Supplement pages. U.S. Hybrid Work Model:
Effective September 5, 2023, employees in office-based positions in the U.S. will work a Hybrid model (three on-site days per week, Monday-Thursday, with Friday remote), subject to site-specific variations and business needs. Salary Range:
$250,800.00 - $394,800.00. The salary is the range we believe we would pay at the time of posting, with starting pay determined by factors including education, qualifications, experience, location, and business needs. Benefits:
We offer a comprehensive package including medical, dental, vision, retirement (401(k)), paid holidays, vacation, and sick days. More information available at the compensation and benefits page. Application:
You can apply at the company careers site or Workday Jobs Hub if you are a current employee. Important:
Job posting end date is specified; apply before the stated end date. Some locations have special local ordinances (e.g., San Francisco, Los Angeles) regarding fair chance considerations.
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Translational Molecular Biomarkers is responsible for translating preclinical molecular biomarkers to clinical development across all therapeutic areas and all phases of clinical development at our company's Research Laboratories. Translational Molecular Biomarkers laboratories leverage a diverse array of technologies to develop biomarker assays to help confirm engagement of therapeutic targets and understand mechanisms of drug action and patient response. The Molecular Pathology group within the Translational Molecular Biomarkers organization is seeking a highly motivated and experienced Anatomic Pathologist (MD) for the role of Principal Scientist (Director) to join our innovative team. This position will play a crucial role in supporting the development, analytical validation, and testing of histopathology-based assays for clinical implementation and advancing digital pathology within our company\'s clinical therapeutic pipeline. Principal Scientist (Director)
will have the following responsibilities: Engage in providing thorough histopathological reviews and testing clinical samples, leveraging expertise in disease processes and pathways targeted by our company\'s therapeutics. Collaborate in the development and analytic validation of digital pathology algorithms. Interface with scientists and physicians in early and late-stage clinical development to execute histopathology-based biomarker strategies in clinical trials. Establish new histopathology-based assays in the laboratory as part of a team. Provide expert pathologist input to discussions in a highly matrixed environment, collaborating with internal and external stakeholders. Position Qualifications
Education Minimum Requirement : Doctor of Medicine (MD or MD/PhD) with specialized training in Anatomic Pathology. Required Experience and Skills : Proficient in routine histopathology testing, immunohistochemistry (IHC), cytogenetics (in-situ hybridization) testing procedures, and applicable laboratory testing regulations. Experience ensuring compliance of a clinical laboratory with regulatory standards. Experience with the development and analytic validation of digital pathology algorithms. Excellent oral and written skills with a proven record of scientific contributions to the scientific community. Demonstrated ability to lead and manage projects in a fast-paced environment. Ability to interact well with diverse groups and maintain strong working relationships with internal and external collaborators. Strong understanding of disease processes and pathways relevant to our company\'s therapeutics. Preferred Experience and Skills : Experience working in the pharmaceutical industry. Broad knowledge of the drug development process and translational medicine. Experience in clinical biomarker development or managing the implementation of biomarker assays in support of drug development. Experience with multiplex tissue-based spatial profiling assays (e.g., multiplex immunofluorescence, multiplex chromogenic immunohistochemistry, imaging mass cytometry). Familiarity with image acquisition platforms (e.g., Leica Aperio, Hamamatsu, Pannoramic). Proficiency in commercial or open-source image analysis software packages (e.g., Visiopharm, HALO, QuPath). Knowledge of using statistical software packages (e.g., Prism, SPSS). Understanding of regulated clinical bioanalysis. Required Skills:
Anatomic Pathology, Biomarker Development, Clinical Studies, Digital Pathology, Molecular Pathology Preferred Skills: Current Employees apply HERE. Current Contingent Workers apply HERE. Additional Information
US and Puerto Rico Residents Only:
Our company is committed to inclusion and provides accommodations during the application or hiring process if needed. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, please visit the EEOC Know Your Rights and EEOC GINA Supplement pages. U.S. Hybrid Work Model:
Effective September 5, 2023, employees in office-based positions in the U.S. will work a Hybrid model (three on-site days per week, Monday-Thursday, with Friday remote), subject to site-specific variations and business needs. Salary Range:
$250,800.00 - $394,800.00. The salary is the range we believe we would pay at the time of posting, with starting pay determined by factors including education, qualifications, experience, location, and business needs. Benefits:
We offer a comprehensive package including medical, dental, vision, retirement (401(k)), paid holidays, vacation, and sick days. More information available at the compensation and benefits page. Application:
You can apply at the company careers site or Workday Jobs Hub if you are a current employee. Important:
Job posting end date is specified; apply before the stated end date. Some locations have special local ordinances (e.g., San Francisco, Los Angeles) regarding fair chance considerations.
#J-18808-Ljbffr