Eli Lilly and Company
Sr. Principal Process Engineer - Oligonucleotides
Eli Lilly and Company, Houston, Texas, United States, 77246
Overview
Sr. Principal Process Engineer - Oligonucleotides at Eli Lilly and Company Lilly is constructing an advanced manufacturing facility for API molecules to support current and future products, including new modalities. The role is part of the startup leadership for this manufacturing site, helping to build the organization, facility, and culture to enable GMP manufacturing operations. Position overview: The Senior Principal Process Engineer provides technical leadership for production operations in oligonucleotide API supply. Responsibilities include mentoring process engineers, sustaining process knowledge, supporting process and equipment optimization, managing equipment qualification and capability, and overseeing engineering systems and assets. During the project delivery and startup phase (expected 2029–2030), the role will be dynamic and collaborative—focused on building the organization, implementing GMP-supporting systems and processes, and shaping site culture to enable successful full-scale manufacturing. Responsibilities
Mentor process engineers in core engineering practices for oligonucleotide API supply Promote data-driven decision-making using statistical methods and first principles Support and review root cause analyses and technical documentation Identify and address process knowledge gaps affecting equipment and process performance Capture key process knowledge such as material and energy balances, kinetics, and design basis Maintain process safety foundations and support hazard reviews Ensure equipment qualification aligns with intended use and remains valid after changes or maintenance Integrate modeling and simulation to enhance process understanding and control Drive continuous improvement in equipment and processes as part of cross-functional teams Lead or support tech transfer of new processes and unit operations Oversee development of user requirements, design reviews, and verification plans Basic Qualifications
Bachelor's Degree in Process, Chemical, Biochemical Engineering or related applicable STEM discipline 5+ years of experience in API Manufacturing Unit Operations Additional Preferences
Experience with API chemical synthesis, biotech operations, and chromatography Familiar with GMP production environments Strong foundation in chemical engineering and technical problem-solving Able to work independently and within cross-functional teams Skilled in coaching and mentoring for technical development Proactive in identifying and implementing improvements Flexible and responsive to evolving business needs Lilly is committed to equal opportunity employment. If you require accommodation to submit a resume, please complete the accommodation request form. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our ERGs support networks for employees. Compensation details depend on education, experience, skills, and location. Actual compensation will be determined accordingly. Full-time employees are eligible for bonus and a comprehensive benefits program.
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Sr. Principal Process Engineer - Oligonucleotides at Eli Lilly and Company Lilly is constructing an advanced manufacturing facility for API molecules to support current and future products, including new modalities. The role is part of the startup leadership for this manufacturing site, helping to build the organization, facility, and culture to enable GMP manufacturing operations. Position overview: The Senior Principal Process Engineer provides technical leadership for production operations in oligonucleotide API supply. Responsibilities include mentoring process engineers, sustaining process knowledge, supporting process and equipment optimization, managing equipment qualification and capability, and overseeing engineering systems and assets. During the project delivery and startup phase (expected 2029–2030), the role will be dynamic and collaborative—focused on building the organization, implementing GMP-supporting systems and processes, and shaping site culture to enable successful full-scale manufacturing. Responsibilities
Mentor process engineers in core engineering practices for oligonucleotide API supply Promote data-driven decision-making using statistical methods and first principles Support and review root cause analyses and technical documentation Identify and address process knowledge gaps affecting equipment and process performance Capture key process knowledge such as material and energy balances, kinetics, and design basis Maintain process safety foundations and support hazard reviews Ensure equipment qualification aligns with intended use and remains valid after changes or maintenance Integrate modeling and simulation to enhance process understanding and control Drive continuous improvement in equipment and processes as part of cross-functional teams Lead or support tech transfer of new processes and unit operations Oversee development of user requirements, design reviews, and verification plans Basic Qualifications
Bachelor's Degree in Process, Chemical, Biochemical Engineering or related applicable STEM discipline 5+ years of experience in API Manufacturing Unit Operations Additional Preferences
Experience with API chemical synthesis, biotech operations, and chromatography Familiar with GMP production environments Strong foundation in chemical engineering and technical problem-solving Able to work independently and within cross-functional teams Skilled in coaching and mentoring for technical development Proactive in identifying and implementing improvements Flexible and responsive to evolving business needs Lilly is committed to equal opportunity employment. If you require accommodation to submit a resume, please complete the accommodation request form. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our ERGs support networks for employees. Compensation details depend on education, experience, skills, and location. Actual compensation will be determined accordingly. Full-time employees are eligible for bonus and a comprehensive benefits program.
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