AstraZeneca
Executive Medical Director, Rheumatology, Early R&I Clinical Development
AstraZeneca, Boston, Massachusetts, us, 02298
Overview
Executive Medical Director, Rheumatology, Early R&I Clinical Development – Boston, MA. The role provides medical leadership for preclinical and clinical stage assets across indications such as SLE, Systemic Sclerosis, Sjogren’s and Rheumatoid arthritis, spanning multiple modalities (small molecules, monoclonal antibodies, bi-specific and tri-specific antibodies, oligonucleotides). You will lead cross-functional clinical development activities, create overall development plans and study designs, write protocols, provide medical monitoring, and ensure timely execution of studies in collaboration with internal/external partners and CROs. You may also participate in in-scope external innovation and business development activities. What You Will Do
Lead design, execution, and interpretation of clinical studies to ensure ethical and scientific integrity of plans, studies, and products. Provide medical strategy and clinical expertise to Research, Translational Medicine, Early and Late-stage Clinical Development, and Commercial Partners, including therapeutic area strategy development. Monitor medical developments within assigned areas and translate emerging data into agile clinical plans. Represent early R&I clinical development to external stakeholders (investigators, external experts, governmental/policy groups, patient advocacy groups). Serve as Medical Lead for regulatory communication and preparation of higher-level documents. Ensure internal and external peer review of potential study/program designs. Support qualification of pharmacodynamic/disease markers for early assessment of efficacy. Provide clinical input to in-licensing opportunities. Qualifications
MD and/or PhD. 10+ years of experience in clinical development in relevant immunology indications, with background in early clinical development (First-in-Human through Ph2b). Proven track record in leading cross-functional teams and delivering results. Understanding of the entire drug development process, including clinical and non-clinical study design and execution. Strong grasp of clinical research methodology and biostatistics to enable innovative and efficient trial designs and data-driven decision rules. Thorough knowledge of FDA, MHRA, and ICH GCP guidelines for conducting studies in the US, Europe, and elsewhere. Attention to detail, self-motivation, and ability to drive goals. Experience managing complex projects and collaborating with multiple stakeholders to drive new strategies and clear communication. Excellent analytical, problem-solving, and strategic planning skills. Ability to thrive in a fast-paced environment. Location
Boston, MA. The organization supports a flexible in-office requirement, with an expectation of in-office presence three days per week on average, while balancing individual flexibility. Compensation and Benefits
The annual base salary ranges from $323,216 to $484,824, with potential short-term incentive and eligibility for an equity-based long-term incentive program. Benefits include a qualified retirement program (401(k)), paid vacation and holidays, paid leaves, and health benefits (medical, prescription drug, dental, and vision). Offer details provided if an offer is extended. At-will employment and possible adjustments to base salary and compensation programs may occur. Additional
Date Posted: 10-Oct-2025 | Closing Date: See official posting. An inclusive environment with equal employment opportunity for all applicants and employees. If you require accommodation due to disability or special need, please indicate it in the application form.
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Executive Medical Director, Rheumatology, Early R&I Clinical Development – Boston, MA. The role provides medical leadership for preclinical and clinical stage assets across indications such as SLE, Systemic Sclerosis, Sjogren’s and Rheumatoid arthritis, spanning multiple modalities (small molecules, monoclonal antibodies, bi-specific and tri-specific antibodies, oligonucleotides). You will lead cross-functional clinical development activities, create overall development plans and study designs, write protocols, provide medical monitoring, and ensure timely execution of studies in collaboration with internal/external partners and CROs. You may also participate in in-scope external innovation and business development activities. What You Will Do
Lead design, execution, and interpretation of clinical studies to ensure ethical and scientific integrity of plans, studies, and products. Provide medical strategy and clinical expertise to Research, Translational Medicine, Early and Late-stage Clinical Development, and Commercial Partners, including therapeutic area strategy development. Monitor medical developments within assigned areas and translate emerging data into agile clinical plans. Represent early R&I clinical development to external stakeholders (investigators, external experts, governmental/policy groups, patient advocacy groups). Serve as Medical Lead for regulatory communication and preparation of higher-level documents. Ensure internal and external peer review of potential study/program designs. Support qualification of pharmacodynamic/disease markers for early assessment of efficacy. Provide clinical input to in-licensing opportunities. Qualifications
MD and/or PhD. 10+ years of experience in clinical development in relevant immunology indications, with background in early clinical development (First-in-Human through Ph2b). Proven track record in leading cross-functional teams and delivering results. Understanding of the entire drug development process, including clinical and non-clinical study design and execution. Strong grasp of clinical research methodology and biostatistics to enable innovative and efficient trial designs and data-driven decision rules. Thorough knowledge of FDA, MHRA, and ICH GCP guidelines for conducting studies in the US, Europe, and elsewhere. Attention to detail, self-motivation, and ability to drive goals. Experience managing complex projects and collaborating with multiple stakeholders to drive new strategies and clear communication. Excellent analytical, problem-solving, and strategic planning skills. Ability to thrive in a fast-paced environment. Location
Boston, MA. The organization supports a flexible in-office requirement, with an expectation of in-office presence three days per week on average, while balancing individual flexibility. Compensation and Benefits
The annual base salary ranges from $323,216 to $484,824, with potential short-term incentive and eligibility for an equity-based long-term incentive program. Benefits include a qualified retirement program (401(k)), paid vacation and holidays, paid leaves, and health benefits (medical, prescription drug, dental, and vision). Offer details provided if an offer is extended. At-will employment and possible adjustments to base salary and compensation programs may occur. Additional
Date Posted: 10-Oct-2025 | Closing Date: See official posting. An inclusive environment with equal employment opportunity for all applicants and employees. If you require accommodation due to disability or special need, please indicate it in the application form.
#J-18808-Ljbffr