Faculty Position - Department of Computational Biology

SJCRH

Be the force behind the cures.

From analyzing complex biomedical data in pediatric cancer to creating innovative technologies and computational tools, your work at St. Jude can directly impact patient care. The

Department of Computational Biology

invites applications for Assistant/Associate/Full Member (faculty) positions in, but not limited to, the following areas: A — Omics Technologies We seek a

computational technology innovator

to develop

next generation omics

platforms for pediatric biology and diseases. Areas of interest include

RNA biology

(splicing/fusions),

CRISPR functional genomics

(CRISPRi/a, Perturb seq, combinatorial screens),

single cell and spatial omics, metabolomics,

and immunopeptidomics. The successful candidate will

pioneer assay–algorithm co design , demonstrate

cross disciplinary leadership

and lead r eproducible & open science B — AI in Biomedicine We seek an

AI‑first scientist

to build

foundation models

and

agentic AI tools

spanning DNA/RNA/protein/imaging/spatial/EHR data for pediatric precision medicine. Topics include

regulatory genomics foundation models ,

multimodal tissue/cell models

(WSI + spatial + single‑cell),

proteogenomic/neoantigen prediction ,

computational pathology

(WSI modeling, slide‑omics fusion) and

clinical informatics , plus

trustworthy AI

(calibration, uncertainty, drift monitoring). Candidates should have a record of impactful

methods/tools , experience with

clinical informatics pipelines , and a commitment to

safe, reproducible, clinic‑ready AI . Experience building

LLM‑driven, agentic systems

for automated analysis or experiment planning with appropriate guardrails is highly valued. Environment & Resources The Department occupies

28,700 square feet

of laboratory and office space. Investigators have dedicated shared resources for

large‑scale data analysis

and

functional validation , including priority access to

cloud computing , a

local high‑performance computing

facility housed in a state‑of‑the‑art data center, a

genomics laboratory

for developing new omics technologies and assays, a

wet lab

supporting dry‑lab faculty, and an

software engineering team

for high‑throughput analysis and pipeline automation. The Department is key in multiple completed and ongoing institutional projects, including Pediatric Cancer Genome Project (PCGP), St. Jude Cloud, PedDep Accelerator, Real Time Clinical Genomics, iTARGETS, and COMET. The research environment at St. Jude is highly collaborative, with opportunities across basic and clinical departments and access to institution‑wide core facilities led by PhD‑level scientists. Compensation & Appointment We offer

highly competitive packages , including generous

startup funds ,

computing resources ,

equipment ,

laboratory space ,

personnel support , and potential

institutional support beyond the start‑up phase . Appointments at the

Assistant or Associate or Full Member

level will be considered. Qualifications PhD (or equivalent)

with at least

three years of relevant postgraduate experience ,

or

a demonstrated track record of developing

novel, high‑impact computational methods .

For Area A: evidence of

assay–algorithm co‑design

in RNA/CRISPR/single‑cell/spatial/metabolomics.

For Area B: experience with

foundation models ,

multimodal learning ,

clinical NLP , and

trustworthy AI ; familiarity with

clinical informatics .

How to Apply

Please submit the following directly

via the online application :

(1)

a curriculum vitae,

(2)

a

2–3 page

summary of research interests, and

(3)

the

names of three references

For more information, contact

ComputationalBiologyRecruitment@stjude.org.

St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

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