Entrada Therapeutics
Senior Research Associate, Formulation Chemistry (CONTRACT)
Entrada Therapeutics, Boston, Massachusetts, us, 02298
Senior Research Associate, Formulation Chemistry (CONTRACT)
Organization
Entrada Therapeutics is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible. Our Endosomal Escape Vehicle (EEV™)-therapeutics enable efficient intracellular delivery of a wide range of therapeutics into a variety of organs and tissues, aiming to improve therapeutic index. Our lead oligonucleotide programs are in development for Duchenne muscular dystrophy (exon skipping amenable to 44, 45, 50 and 51) and we have a partnered clinical-stage program (VX-670) for myotonic dystrophy type 1. We are a collaborative, fast-paced team focused on delivering impact for patients and their families. Role Overview
In this role, the candidate will be responsible for the analysis and formulation of oligonucleotides/peptides/conjugates/other novel molecules, documenting experiments, and coordinating timelines with internal teams. They will manage chemical inventory and maintain robust experimental records. The candidate will interpret and present research data in internal meetings and prepare procedures and technical reports. Responsibilities Develop and optimize analytical methods for analysis of oligonucleotide/peptide/conjugates and other novel modalities. Work with the material generation team to perform in-process control and release tests using techniques such as HPLC and LCMS. Coordinate with internal stakeholders to ensure materials are available to maintain the project timeline. Formulate and characterize oligonucleotide/peptide/conjugates and other novel modalities for in vitro and in vivo studies to support discovery projects. Support in-house stability studies. Maintain and troubleshoot analytical instruments to ensure high performance. Coordinate with cross-functional teams for data and sample transfers. Organize and document all experimental data using an electronic lab notebook (ELN). Author protocols, standard operating procedures and technical reports. Contribute to reports and presentations; interpret and present research data during internal meetings. Requirements / “Necessities” Bachelor’s degree with 4+ years of relevant experience or Master’s degree with 2+ years in Pharmaceutical Sciences, Chemistry, or a related field. Hands-on experience with HPLC (e.g., SEC, IEX, HIC), LCMS and other analytical techniques; knowledge of laboratory safety and best practices. Experience with analytical method development is a plus; experience with formulation is a plus; experience with aseptic handling techniques is a plus. Attention to detail and thorough documentation of experimental work in electronic lab notebooks (ELNs). Understanding of oligonucleotide/peptide chemistry and analytical chemistry is a plus. Excellent written and verbal communication skills to document SOPs/reports and present findings. Ability to work effectively in a multi-disciplinary, fast-paced research environment and manage multiple tasks to meet development goals. This is a one-year contract position with the potential for extension depending on business needs. Equal Opportunity Entrada Therapeutics is an equal opportunity employer. Qualified candidates will be considered for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law. Note : This description may include references to third-party staffing and privacy statements as part of standard company communications.
#J-18808-Ljbffr
Organization
Entrada Therapeutics is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible. Our Endosomal Escape Vehicle (EEV™)-therapeutics enable efficient intracellular delivery of a wide range of therapeutics into a variety of organs and tissues, aiming to improve therapeutic index. Our lead oligonucleotide programs are in development for Duchenne muscular dystrophy (exon skipping amenable to 44, 45, 50 and 51) and we have a partnered clinical-stage program (VX-670) for myotonic dystrophy type 1. We are a collaborative, fast-paced team focused on delivering impact for patients and their families. Role Overview
In this role, the candidate will be responsible for the analysis and formulation of oligonucleotides/peptides/conjugates/other novel molecules, documenting experiments, and coordinating timelines with internal teams. They will manage chemical inventory and maintain robust experimental records. The candidate will interpret and present research data in internal meetings and prepare procedures and technical reports. Responsibilities Develop and optimize analytical methods for analysis of oligonucleotide/peptide/conjugates and other novel modalities. Work with the material generation team to perform in-process control and release tests using techniques such as HPLC and LCMS. Coordinate with internal stakeholders to ensure materials are available to maintain the project timeline. Formulate and characterize oligonucleotide/peptide/conjugates and other novel modalities for in vitro and in vivo studies to support discovery projects. Support in-house stability studies. Maintain and troubleshoot analytical instruments to ensure high performance. Coordinate with cross-functional teams for data and sample transfers. Organize and document all experimental data using an electronic lab notebook (ELN). Author protocols, standard operating procedures and technical reports. Contribute to reports and presentations; interpret and present research data during internal meetings. Requirements / “Necessities” Bachelor’s degree with 4+ years of relevant experience or Master’s degree with 2+ years in Pharmaceutical Sciences, Chemistry, or a related field. Hands-on experience with HPLC (e.g., SEC, IEX, HIC), LCMS and other analytical techniques; knowledge of laboratory safety and best practices. Experience with analytical method development is a plus; experience with formulation is a plus; experience with aseptic handling techniques is a plus. Attention to detail and thorough documentation of experimental work in electronic lab notebooks (ELNs). Understanding of oligonucleotide/peptide chemistry and analytical chemistry is a plus. Excellent written and verbal communication skills to document SOPs/reports and present findings. Ability to work effectively in a multi-disciplinary, fast-paced research environment and manage multiple tasks to meet development goals. This is a one-year contract position with the potential for extension depending on business needs. Equal Opportunity Entrada Therapeutics is an equal opportunity employer. Qualified candidates will be considered for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law. Note : This description may include references to third-party staffing and privacy statements as part of standard company communications.
#J-18808-Ljbffr