Moderna Therapeutics
General Manager, Rare Diseases page is loaded General Manager, Rare Diseases Apply locations Cambridge, Massachusetts Commercial time type Full time posted on Posted 17 Days Ago job requisition id R17976
The Role: As the General Manager for Rare Diseases, you will report to the Chief Marketing Officer and have end-to-end accountability for the Rare Disease Business Unit (BU), including mRNA-3927 for Propionic Acidemia (PA), mRNA-3705 for Methylmalonic Acidemia (MMA) and a pipeline of pre-clinical candidates . This is an enterprise-level leadership role with cross-functional accountability. In addition to managing the P&L, setting strategy and leading commercialization efforts, you will integrate activities across critical functions such as Manufacturing, Research and Clinical Development. While you will have dotted-line functional reports from these areas, you will also maintain dual accountability to relevant enterprise leaders. This includes ensuring that strategic planning, execution, and communication align with the broader corporate goals and stakeholder expectations. You will also serve as the Rare Disease Franchise Lead, managing the marketing team directly, while also acting as a key integrator across internal teams to drive prioritization, resourcing, and global-to-local readiness for successful asset launches and long-term portfolio growth. Here’s What You’ll Do: Lead Moderna’s Rare Disease Franchise with full strategic, operational, and financial accountability
Manage the Business Unit P&L
Own the integrated franchise strategy, including pipeline prioritization, lifecycle planning, and long-range forecasting
Develop compelling business cases and value narratives that shape investment and development decisions
Represent Rare Disease in governance forums and drive cross-functional priority-setting aligned with company strategy
Orchestrate execution across Marketing, R&D, Medical, Access, CMC, and Supply to deliver launches on time and within budget
Shape the go-to-market model, brand strategy, and external positioning to ensure global readiness and local adaptability
Partner with country and regional teams to drive alignment, insight-sharing, and sustained execution across markets
Build and scale commercial infrastructure and capabilities to support asset launches and portfolio expansion
Identify and develop long-term opportunity spaces and commercial innovation within the rare disease landscape
Lead structured planning, forecasting, budget management, and KPI tracking across the franchise
Influence enterprise-level portfolio prioritization and long-term growth strategy through active participation in global forums
Here’s What You’ll Need (Minimum Qualifications): Bachelor’s degree required
15+ years of progressive experience with significant commercial leadership exposure
Proven track record in end-to-end portfolio leadership, including launch execution, and lifecycle management
Direct U.S. launch experience in rare or specialty disease areas
Experience leading high-performing teams and cross-functional collaborations
Here’s What You’ll Bring to the Table (Preferred Qualifications): Full P&L ownership and accountability for the BU
Experience building and scaling commercial infrastructure in emerging or fast-growth therapeutic areas
Depth in rare or ultra-rare diseases, with working knowledge of clinical and regulatory pathways.
Strong understanding of global healthcare systems, access models, and payer engagement
Demonstrated success building and scaling teams in ambiguous or early-growth environments
Proven ability to influence across R&D, Medical, Access, and G&A functions
Strategic thinker with high learning agility, systems orientation, and disciplined operational follow-through
Executive presence with clear communication and alignment-building skills across senior leadership.
At Moderna, we believe that when you feel your best, you can do your best work. That’s why our US benefits and global well-being resources are designed to support you—at work, at home, and everywhere in between. Best-in-class healthcare coverage, plus a suite of voluntary benefit programs to support your unique needs A holistic approach to well-being, with access to fitness, mindfulness, and mental health support Lifestyle Spending Accounts to personalize your well-being journey Family planning and adoption benefits Generous paid time off, including vacation, volunteer days, sabbatical, global recharge days, and a discretionary year-end shutdown Savings and investment opportunities Location-specific perks and extras About Moderna Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world. By living our mission, values, and mindsets every day, our people are the driving force behind our scientific progress and our culture. Together, we are creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities. We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. Our Working Model As we build our company, we have always believed an in-person culture is critical to our success. Moderna champions the significant benefits of in-office collaboration by embracing a 70/30 work model. This 70% in-office structure helps to foster a culture rich in innovation, teamwork, and direct mentorship. Join us in shaping a world where every interaction is an opportunity to learn, contribute, and make a meaningful impact. Moderna is a smoke-free, alcohol-free, and drug-free work environment. Equal Opportunities Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law. Moderna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply! Moderna is an E-Verify Employer in the United States. We consider qualified applicants regardless of criminal histories, consistent with legal requirements. Accommodations We’re focused on attracting, retaining, developing, and advancing our employees. By cultivating a workplace that values diverse experiences, backgrounds, and ideas, we create an environment where every employee can contribute their best. Moderna is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should contact the Accommodations team at leavesandaccommodations@modernatx.com . #LI-AG2 - Similar Jobs (1)
Vice President, Marketing, Oncology locations 2 Locations time type Full time posted on Posted 30+ Days Ago At Moderna we are pioneering the development of a new class of drugs made of messenger RNA (mRNA). This novel drug platform builds on the discovery that modified mRNA can direct the body’s cellular machinery to produce nearly any protein of interest, from native proteins to antibodies and other entirely novel protein constructs that can have therapeutic activity inside and outside of cells. We have a clear mission to propel the field of mRNA science forward and deliver new medicines to patients and a unique vision for how to achieve this mission. Our Mission : To deliver on the promise of transformative messenger RNA (mRNA) science to bring new medicines to patients. Our Vision : To unlock the potential of mRNA by establishing an ecosystem of teams and partners that will work together to develop the broadest possible array of drugs, across diverse therapeutic areas and routes of administration, for serious diseases that are not treatable today. Third Party Staffing Agencies M oderna does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Moderna from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Moderna and do not obligate Moderna to pay fees if we hire from those resumes. Reasonable Accommodation Notice Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.Applicants with disabilities may be entitled to reasonable accommodation under the terms of the Americans with Disabilities Act and certain state or local laws. Please inform the company's personnel representative by calling 617-460-9346 or emailing humanresources@modernatx.com if you need assistance completing any forms or to otherwise participate in the application process.Examples of reasonable accommodation include making a change to the application process or work procedures, providing documents in an alternate format, using a sign language interpreter, or using specialized equipment.
#J-18808-Ljbffr
The Role: As the General Manager for Rare Diseases, you will report to the Chief Marketing Officer and have end-to-end accountability for the Rare Disease Business Unit (BU), including mRNA-3927 for Propionic Acidemia (PA), mRNA-3705 for Methylmalonic Acidemia (MMA) and a pipeline of pre-clinical candidates . This is an enterprise-level leadership role with cross-functional accountability. In addition to managing the P&L, setting strategy and leading commercialization efforts, you will integrate activities across critical functions such as Manufacturing, Research and Clinical Development. While you will have dotted-line functional reports from these areas, you will also maintain dual accountability to relevant enterprise leaders. This includes ensuring that strategic planning, execution, and communication align with the broader corporate goals and stakeholder expectations. You will also serve as the Rare Disease Franchise Lead, managing the marketing team directly, while also acting as a key integrator across internal teams to drive prioritization, resourcing, and global-to-local readiness for successful asset launches and long-term portfolio growth. Here’s What You’ll Do: Lead Moderna’s Rare Disease Franchise with full strategic, operational, and financial accountability
Manage the Business Unit P&L
Own the integrated franchise strategy, including pipeline prioritization, lifecycle planning, and long-range forecasting
Develop compelling business cases and value narratives that shape investment and development decisions
Represent Rare Disease in governance forums and drive cross-functional priority-setting aligned with company strategy
Orchestrate execution across Marketing, R&D, Medical, Access, CMC, and Supply to deliver launches on time and within budget
Shape the go-to-market model, brand strategy, and external positioning to ensure global readiness and local adaptability
Partner with country and regional teams to drive alignment, insight-sharing, and sustained execution across markets
Build and scale commercial infrastructure and capabilities to support asset launches and portfolio expansion
Identify and develop long-term opportunity spaces and commercial innovation within the rare disease landscape
Lead structured planning, forecasting, budget management, and KPI tracking across the franchise
Influence enterprise-level portfolio prioritization and long-term growth strategy through active participation in global forums
Here’s What You’ll Need (Minimum Qualifications): Bachelor’s degree required
15+ years of progressive experience with significant commercial leadership exposure
Proven track record in end-to-end portfolio leadership, including launch execution, and lifecycle management
Direct U.S. launch experience in rare or specialty disease areas
Experience leading high-performing teams and cross-functional collaborations
Here’s What You’ll Bring to the Table (Preferred Qualifications): Full P&L ownership and accountability for the BU
Experience building and scaling commercial infrastructure in emerging or fast-growth therapeutic areas
Depth in rare or ultra-rare diseases, with working knowledge of clinical and regulatory pathways.
Strong understanding of global healthcare systems, access models, and payer engagement
Demonstrated success building and scaling teams in ambiguous or early-growth environments
Proven ability to influence across R&D, Medical, Access, and G&A functions
Strategic thinker with high learning agility, systems orientation, and disciplined operational follow-through
Executive presence with clear communication and alignment-building skills across senior leadership.
At Moderna, we believe that when you feel your best, you can do your best work. That’s why our US benefits and global well-being resources are designed to support you—at work, at home, and everywhere in between. Best-in-class healthcare coverage, plus a suite of voluntary benefit programs to support your unique needs A holistic approach to well-being, with access to fitness, mindfulness, and mental health support Lifestyle Spending Accounts to personalize your well-being journey Family planning and adoption benefits Generous paid time off, including vacation, volunteer days, sabbatical, global recharge days, and a discretionary year-end shutdown Savings and investment opportunities Location-specific perks and extras About Moderna Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world. By living our mission, values, and mindsets every day, our people are the driving force behind our scientific progress and our culture. Together, we are creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities. We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. Our Working Model As we build our company, we have always believed an in-person culture is critical to our success. Moderna champions the significant benefits of in-office collaboration by embracing a 70/30 work model. This 70% in-office structure helps to foster a culture rich in innovation, teamwork, and direct mentorship. Join us in shaping a world where every interaction is an opportunity to learn, contribute, and make a meaningful impact. Moderna is a smoke-free, alcohol-free, and drug-free work environment. Equal Opportunities Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law. Moderna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply! Moderna is an E-Verify Employer in the United States. We consider qualified applicants regardless of criminal histories, consistent with legal requirements. Accommodations We’re focused on attracting, retaining, developing, and advancing our employees. By cultivating a workplace that values diverse experiences, backgrounds, and ideas, we create an environment where every employee can contribute their best. Moderna is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should contact the Accommodations team at leavesandaccommodations@modernatx.com . #LI-AG2 - Similar Jobs (1)
Vice President, Marketing, Oncology locations 2 Locations time type Full time posted on Posted 30+ Days Ago At Moderna we are pioneering the development of a new class of drugs made of messenger RNA (mRNA). This novel drug platform builds on the discovery that modified mRNA can direct the body’s cellular machinery to produce nearly any protein of interest, from native proteins to antibodies and other entirely novel protein constructs that can have therapeutic activity inside and outside of cells. We have a clear mission to propel the field of mRNA science forward and deliver new medicines to patients and a unique vision for how to achieve this mission. Our Mission : To deliver on the promise of transformative messenger RNA (mRNA) science to bring new medicines to patients. Our Vision : To unlock the potential of mRNA by establishing an ecosystem of teams and partners that will work together to develop the broadest possible array of drugs, across diverse therapeutic areas and routes of administration, for serious diseases that are not treatable today. Third Party Staffing Agencies M oderna does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Moderna from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Moderna and do not obligate Moderna to pay fees if we hire from those resumes. Reasonable Accommodation Notice Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.Applicants with disabilities may be entitled to reasonable accommodation under the terms of the Americans with Disabilities Act and certain state or local laws. Please inform the company's personnel representative by calling 617-460-9346 or emailing humanresources@modernatx.com if you need assistance completing any forms or to otherwise participate in the application process.Examples of reasonable accommodation include making a change to the application process or work procedures, providing documents in an alternate format, using a sign language interpreter, or using specialized equipment.
#J-18808-Ljbffr