Bristol Myers Squibb
Senior Principal Scientist, Cell Therapy Research, Molecular Immunobiology and D
Bristol Myers Squibb, Seattle, Washington, us, 98127
Senior Principal Scientist, Cell Therapy Research, Molecular Immunobiology and Discovery Team
Join Bristol Myers Squibb as a Senior Principal Scientist in the Cell Therapy Molecular Immunobiology and Discovery team.
In this role you will be a key leader in molecular design, lentiviral and AAV engineering, and viral and non‑viral production methods to accelerate next‑generation cellular therapeutic pipelines.
Position Summary The Cell Therapy Molecular Immunobiology and Discovery team seeks a highly motivated, dynamic, and self‑driven scientist to deliver on our critical goals.
The selected candidate will focus on designing and validating novel molecular cargoes, backbones, and viral particles; optimize research‑grade virus production for early‑stage CAR T programs; and work with the automation team to innovate pipelines that increase production and transduction efficiency.
You will be a seasoned molecular biologist and virologist with strong expertise in viral vector engineering and an in‑depth understanding of transgene delivery challenges.
Key Responsibilities
Lead a team to develop innovative molecular engineering strategies and viral production methods that improve expression, function, and throughput.
Design experiments, organize and analyze results, and communicate progress to the group.
Evaluate and prioritize molecular technologies, gene‑delivery cassettes, and viral platforms, delivering complete data packages for timely Go/No Go decisions.
Collaborate with SMEs inside and outside the team to assess the functional impact of novel engineering strategies on our CAR and eTCR cell products.
Work with other team members and leaders to enable adoption of new methods and designs in ongoing programs.
Lead a matrixed group of scientists and research associates, providing direct supervision under limited management oversight.
Understand the context, impact, and timely communication of data.
Qualifications & Experience
Bachelor’s (or Master’s/Ph.D.) degree in Life Sciences.
10+ yrs of academic and/or industry experience for Bachelor’s, 8+ yrs for Master’s, 6+ yrs for Ph.D. level.
Preferred Qualifications
Strong virology expertise, preferably lentiviral, with experience using other viruses and non‑viral delivery methods.
Deep understanding of gene‑regulation principles and optimization of transgene expression and function.
Extensive experience delivering molecular cargoes into human primary cells, ideally T cells.
Proficiency in molecular characterization to understand and optimize transgene performance.
Excellent organizational, multitasking, communication, and facilitation skills.
Attention to detail, creative problem‑solving, and adaptability to a fast‑paced environment.
Willingness to think outside the box.
Additional Relevant Qualifications
Industry experience in adoptive engineered T‑cell therapeutics (CAR‑T or eTCR).
Experience with viral and non‑viral gene delivery for gene‑therapy products.
Experience with in‑vitro T cell functionality assays, flow cytometry, activation, proliferation, and imaging.
Experience with high‑throughput screening.
Compensation Overview Seattle, WA: $191,860 – $232,492 per year.
Additional incentive cash and stock opportunities may be available based on eligibility.
Final compensation will depend on demonstrated experience.
Benefits Bristol Myers Squibb offers a broad range of benefits, including medical, pharmacy, dental, vision, wellbeing programs, employee assistance programs, 401(k) and other financial resources, paid time off, parental and caregiving leave, tuition reimbursement, and more.
Our inclusion initiatives support a culture built on passion, innovation, and equity.
Equal Employment Opportunity BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable accommodations, and ongoing support.
Applicants may request accommodations prior to accepting a job offer.
On‑site Protocol Roles may require onsite work, hybrid models, or remote work based on job responsibilities and company policies.
Detailed occupancy information is available upon request.
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In this role you will be a key leader in molecular design, lentiviral and AAV engineering, and viral and non‑viral production methods to accelerate next‑generation cellular therapeutic pipelines.
Position Summary The Cell Therapy Molecular Immunobiology and Discovery team seeks a highly motivated, dynamic, and self‑driven scientist to deliver on our critical goals.
The selected candidate will focus on designing and validating novel molecular cargoes, backbones, and viral particles; optimize research‑grade virus production for early‑stage CAR T programs; and work with the automation team to innovate pipelines that increase production and transduction efficiency.
You will be a seasoned molecular biologist and virologist with strong expertise in viral vector engineering and an in‑depth understanding of transgene delivery challenges.
Key Responsibilities
Lead a team to develop innovative molecular engineering strategies and viral production methods that improve expression, function, and throughput.
Design experiments, organize and analyze results, and communicate progress to the group.
Evaluate and prioritize molecular technologies, gene‑delivery cassettes, and viral platforms, delivering complete data packages for timely Go/No Go decisions.
Collaborate with SMEs inside and outside the team to assess the functional impact of novel engineering strategies on our CAR and eTCR cell products.
Work with other team members and leaders to enable adoption of new methods and designs in ongoing programs.
Lead a matrixed group of scientists and research associates, providing direct supervision under limited management oversight.
Understand the context, impact, and timely communication of data.
Qualifications & Experience
Bachelor’s (or Master’s/Ph.D.) degree in Life Sciences.
10+ yrs of academic and/or industry experience for Bachelor’s, 8+ yrs for Master’s, 6+ yrs for Ph.D. level.
Preferred Qualifications
Strong virology expertise, preferably lentiviral, with experience using other viruses and non‑viral delivery methods.
Deep understanding of gene‑regulation principles and optimization of transgene expression and function.
Extensive experience delivering molecular cargoes into human primary cells, ideally T cells.
Proficiency in molecular characterization to understand and optimize transgene performance.
Excellent organizational, multitasking, communication, and facilitation skills.
Attention to detail, creative problem‑solving, and adaptability to a fast‑paced environment.
Willingness to think outside the box.
Additional Relevant Qualifications
Industry experience in adoptive engineered T‑cell therapeutics (CAR‑T or eTCR).
Experience with viral and non‑viral gene delivery for gene‑therapy products.
Experience with in‑vitro T cell functionality assays, flow cytometry, activation, proliferation, and imaging.
Experience with high‑throughput screening.
Compensation Overview Seattle, WA: $191,860 – $232,492 per year.
Additional incentive cash and stock opportunities may be available based on eligibility.
Final compensation will depend on demonstrated experience.
Benefits Bristol Myers Squibb offers a broad range of benefits, including medical, pharmacy, dental, vision, wellbeing programs, employee assistance programs, 401(k) and other financial resources, paid time off, parental and caregiving leave, tuition reimbursement, and more.
Our inclusion initiatives support a culture built on passion, innovation, and equity.
Equal Employment Opportunity BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable accommodations, and ongoing support.
Applicants may request accommodations prior to accepting a job offer.
On‑site Protocol Roles may require onsite work, hybrid models, or remote work based on job responsibilities and company policies.
Detailed occupancy information is available upon request.
#J-18808-Ljbffr